MIPS1 myo-inositol-1-phosphate synthase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MIPS1
Official Full Name: myo-inositol-1-phosphate synthase 1
Primary source: TAIR:AT4G39800
Locus tag: AT4G39800
See related: Araport:AT4G39800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATIPS1; ATMIPS1; ATMIPS2; D-myo-Inositol 3-Phosphate Synthase 1; INOSITOL 3-PHOSPHATE SYNTHASE 1; MI-1-P SYNTHASE; MIPS2; MYO-INOSITOL-1-PHOSPHATE SYNTHASE; myo-inositol-1-phosphate synthase 1; MYO-INOSITOL-1-PHOSPHATE SYNTHASE 1; myo-inositol-1-phosphate synthase 2; MYO-INOSITOL-1-PHOSTPATE SYNTHASE 1; MYO-INOSITOL-1-PHOSTPATE SYNTHASE 2; T19P19.190; T19P19_190; T5J17.3
Summary: ** Referred to as MIPS2 in Mitsuhashi et al 2008. myo-inositol-1-phosphate synthase isoform 1.Expressed in leaf, root and silique. Immunolocalization experiments with an antibody recognizing MIPS1, MIPS2, and MIPS3 showed endosperm localization.
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Genomic context

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See MIPS1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (18469255..18472048, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

works with MIPS2 AND MIPS3 to impact the overall synthesis of myo-inositol and overall inositol homeostasis
Title: Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis.
FHY3 and FAR1 directly bind the promoter of MIPS1 to activate its expression and thereby promote inositol biosynthesis to prevent
Title: Arabidopsis FHY3 and FAR1 Regulate Light-Induced myo-Inositol Biosynthesis and Oxidative Stress Responses by Transcriptional Activation of MIPS1.
chlorophyll accumulation Is required for the onset of programmed cell death (PCD) in myoinositol phosphate synthase1 (mips1) mutant.
Title: Chloroplast Activity and 3'phosphadenosine 5'phosphate Signaling Regulate Programmed Cell Death in Arabidopsis.
MIPS1 binds directly to its promoter to stimulate its own expression by locally inhibiting the spreading of ATXR5/6-dependent heterochromatin marks coming from a transposable element.
Title: Dual function of MIPS1 as a metabolic enzyme and transcriptional regulator.
MIPS1 has a significant impact on myo-inositol levels that is critical for maintaining levels of ascorbic acid, phosphatidylinositol, and ceramides that regulate growth, development, and cell death.
Title: The Arabidopsis thaliana Myo-inositol 1-phosphate synthase1 gene is required for Myo-inositol synthesis and suppression of cell death.
Though MIPS localizes to the cytosol primarily in the endosperm during seed development, myo-inositol-6-phosphate, the final product of inositol phosphate metabolism, was present mainly in the embryo.
Title: Localization of myo-inositol-1-phosphate synthase to the endosperm in developing seeds of Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120143.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables inositol-3-phosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-3-phosphate synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables inositol-3-phosphate synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inositol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myo-inositol hexakisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylserine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: myo-inositol-1-phosphate synthase 1

NP_195690.1

myo-inositol-1-phosphate synthase 1 (MIPS1); CONTAINS InterPro DOMAIN/s: Myo-inositol-1-phosphate synthase (InterPro:IPR002587), Myo-inositol-1-phosphate synthase, GAPDH-like (InterPro:IPR013021), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: myo-inositol-1-phosphate synthase 2 (TAIR:AT2G22240.1); Has 1863 Blast hits to 1859 proteins in 511 species: Archae - 107; Bacteria - 438; Metazoa - 126; Fungi - 158; Plants - 764; Viruses - 0; Other Eukaryotes - 270 (source: NCBI BLink).