EGY2 ethylene-dependent gravitropism-deficient and yellow-green-like 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: EGY2
Official Full Name: ethylene-dependent gravitropism-deficient and yellow-green-like 2
Primary source: TAIR:AT5G05740
Locus tag: AT5G05740
See related: Araport:AT5G05740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATEGY2; ethylene-dependent gravitropism-deficient and yellow-green-like 2; MJJ3.15; MJJ3_15
Summary: S2P-like putative metalloprotease, also contain transmembrane helices near their C-termini and many of them, five of seven, contain a conserved zinc-binding motif HEXXH. Homolog of EGY1. Each of the EGY1 and EGY-like proteins share two additional highly conserved motifs, the previously reported NPDG motif (aa 442#Aei454 in EGY1, Rudner et al., 1999) and a newly defined GNLR motif (aa 171#Aei179 in EGY1). The GNLR motif is a novel signature motif unique to EGY1 and EGY-like proteins as well as other EGY1 orthologs found in cyanobacteria.
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Genomic context

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See EGY2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 12

Sequence:: Chromosome: 5; NC_003076.8 (1723687..1727068, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGY2 metalloprotease plays a role in hypocotyl elongation likely through a RIP dependent process to regulate the coordinated expression of nuclear- and plastid-encoded genes.
Title: EGY2, a chloroplast membrane metalloprotease, plays a role in hypocotyl elongation in Arabidopsis.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001203303.1

Supported by ESTs:

NM_120656.3

Supported by ESTs:

NM_203007.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast thylakoid membrane	HDA more info	PubMed

General protein information

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Preferred Names: ethylene-dependent gravitropism-deficient and yellow-green-like 2

NP_001190232.1

ethylene-dependent gravitropism-deficient and yellow-green-like 2 (EGY2); FUNCTIONS IN: metalloendopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M50 (InterPro:IPR008915); BEST Arabidopsis thaliana protein match is: Peptidase M50 family protein (TAIR:AT5G35220.1).

NP_196193.1

ethylene-dependent gravitropism-deficient and yellow-green-like 2 (EGY2); FUNCTIONS IN: metalloendopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M50 (InterPro:IPR008915); BEST Arabidopsis thaliana protein match is: Peptidase M50 family protein (TAIR:AT5G35220.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NP_974736.1

ethylene-dependent gravitropism-deficient and yellow-green-like 2 (EGY2); FUNCTIONS IN: metalloendopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M50 (InterPro:IPR008915); BEST Arabidopsis thaliana protein match is: Peptidase M50 family protein (TAIR:AT5G35220.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

1723687..1727068 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_203007.3 → NP_974736.1 ethylene-dependent gravitropism-deficient and yellow-green-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974736.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UT70, A0A654FZ27, F4K0T7

Conserved Domains (1) summary

cd06160
Location:270 → 475

S2P-M50_like_2; Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the ...
NM_120656.3 → NP_196193.1 ethylene-dependent gravitropism-deficient and yellow-green-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196193.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FFK3

UniProtKB/TrEMBL

A0A178UT70

Conserved Domains (2) summary

cd06160
Location:299 → 504

S2P-M50_like_2; Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the ...

COG0750
Location:310 → 505

RseP; Membrane-associated protease RseP, regulator of RpoE activity [Posttranslational modification, protein turnover, chaperones, Transcription]
NM_001203303.1 → NP_001190232.1 ethylene-dependent gravitropism-deficient and yellow-green-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190232.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178URT4, A0A5S9Y2J3, F4K0T6

Conserved Domains (1) summary

cd06160
Location:267 → 472

S2P-M50_like_2; Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the ...