SLY2 F-box family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: SLY2
Official Full Name: F-box family protein
Primary source: TAIR:AT5G48170
Locus tag: AT5G48170
See related: Araport:AT5G48170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MIF21.6; MIF21_6; SLEEPY2; SNE; SNEEZY
Summary: encodes an F-box protein whose protein sequence is similar to SLY1, which belongs to SCF-SLY1 E3 ligase complex. SCF-SLY1 E3 ligase degrades DELLA proteins that are involved in promoting growth. Overexpression of SLY2 can partially compensate sly1-10 mutant phenotype of dwarfism.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis.
Title: HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis.
SNEEZY functions as a redundant positive regulator of gibberellin signaling.[SNEEZY] [SLEEPY2]
Title: Mutations in the F-box gene SNEEZY result in decreased Arabidopsis GA signaling.
SNE function partly overlaps with SLY1 function in gibberellin signaling.
Title: The role of two f-box proteins, SLEEPY1 and SNEEZY, in Arabidopsis gibberellin signaling.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_124191.4

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within gibberellic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gibberellic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of shoot system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_199628.1

SLEEPY2 (SLY2); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364); BEST Arabidopsis thaliana protein match is: F-box family protein (TAIR:AT4G24210.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).