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    emb2746 RNA-metabolising metallo-beta-lactamase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836461, updated on 18-Sep-2024

    Summary

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    Official Symbol
    emb2746
    Official Full Name
    RNA-metabolising metallo-beta-lactamase family protein
    Primary source
    TAIR:AT5G63420
    Locus tag
    AT5G63420
    See related
    Araport:AT5G63420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    embryo defective 2746; MLE2.5; MLE2_5
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    Genomic context

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    See emb2746 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Sequence:
    Chromosome: 5; NC_003076.8 (25400317..25406250)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene adenylate kinase 1 Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene hypothetical protein (DUF167) Neighboring gene cytochrome P450, family 94, subfamily B, polypeptide 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis chloroplast RNase J displays both exo- and robust endonucleolytic activities. Halpert M, et al. Plant Mol Biol, 2019 Jan. PMID 30511330
    2. Ribonuclease J is required for chloroplast and embryo development in Arabidopsis. Chen H, et al. J Exp Bot, 2015 Apr. PMID 25871650, Free PMC Article
    3. Chloroplast RNase J compensates for inefficient transcription termination by removal of antisense RNA. Sharwood RE, et al. RNA, 2011 Dec. PMID 22033332, Free PMC Article
    4. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
    5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The robust endonucleolytic activity of AtRNase J suggests its involvement in the processing and degradation of RNA in the chloroplast.
      Title: The Arabidopsis chloroplast RNase J displays both exo- and robust endonucleolytic activities.
    2. Ribonuclease J (RNase J) may play a vital role in embryo morphogenesis and apical-basal pattern formation by regulating chloroplast development.
      Title: Ribonuclease J is required for chloroplast and embryo development in Arabidopsis.
    3. a major role of chloroplast RNase J is RNA surveillance to prevent overaccumulation of antisense RNA, which would otherwise exert deleterious effects on chloroplast gene expression. [RNase J]
      Title: Chloroplast RNase J compensates for inefficient transcription termination by removal of antisense RNA.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_125737.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within longitudinal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    RNA-metabolising metallo-beta-lactamase family protein
    NP_201147.2
    • embryo defective 2746 (emb2746); FUNCTIONS IN: hydrolase activity, DNA binding, catalytic activity; INVOLVED IN: metabolic process, embryo development ending in seed dormancy; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), RNA-metabolising metallo-beta-lactamase (InterPro:IPR011108), Beta-lactamase-like (InterPro:IPR001279), MYB-like (InterPro:IPR017877); BEST Arabidopsis thaliana protein match is: Homeodomain-like superfamily protein (TAIR:AT2G38250.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25400317..25406250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125737.4 → NP_201147.2  RNA-metabolising metallo-beta-lactamase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201147.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q67YC1, Q84W56, Q9FMV9, Q9FMW0
      UniProtKB/TrEMBL
      A0A178UH95, A0A5S9YHU8, A0A654GDS8
      Conserved Domains (2) summary
      cd12203
      Location:819 → 884
      GT1; myb-like, SANT family
      COG0595
      Location:103 → 659
      RnjA; mRNA degradation ribonuclease J1/J2 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84W56.1

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