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    PBRP plant-specific TFIIB-related protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829817, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PBRP
    Official Full Name
    plant-specific TFIIB-related protein
    Primary source
    TAIR:AT4G36650
    Locus tag
    AT4G36650
    See related
    Araport:AT4G36650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AP22.23; AP22_23; ATPBRP; plant-specific TFIIB-related protein
    Summary
    Encodes a protein with similarity to the general transcription factor TFIIB. pBRP binds rDNA sequences in vitro. pBRP has been localized to the outer face of the plastid membrane with GFP fusion however, under conditions of proteosome inhibition it is found in the nucleus.
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    Genomic context

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    See PBRP in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (17283033..17285656, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene ncRNA Neighboring gene polyol transporter, putative (DUF1195) Neighboring gene Major facilitator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant-specific TFIIB-related protein, pBrp, is a general transcription factor for RNA polymerase I. Imamura S, et al. EMBO J, 2008 Sep 3. PMID 18668124, Free PMC Article
    2. Double mutation of BRF1 and BRF2 leads to sterility in Arabidopsis thaliana. Zhang K, et al. Biochem Biophys Res Commun, 2019 Aug 27. PMID 31277948
    3. Transcription factor IIB (TFIIB)-related protein (pBrp), a plant-specific member of the TFIIB-related protein family. Lagrange T, et al. Mol Cell Biol, 2003 May. PMID 12697827, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Double mutation of BRF1 and BRF2 leads to sterility in Arabidopsis thaliana.
      Title: Double mutation of BRF1 and BRF2 leads to sterility in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001085033.4
    NM_119828.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rDNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plant-specific TFIIB-related protein
    NP_001078502.4
    • plant-specific TFIIB-related protein (PBRP); FUNCTIONS IN: RNA polymerase II transcription factor activity, rDNA binding; INVOLVED IN: translational initiation, regulation of transcription, DNA-dependent, transcription initiation; LOCATED IN: plastid outer membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor TFIIB related (InterPro:IPR000812), Transcription factor TFIIB, cyclin-related (InterPro:IPR013150), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: transcription factor IIB (TAIR:AT2G41630.1); Has 1297 Blast hits to 1296 proteins in 319 species: Archae - 504; Bacteria - 1; Metazoa - 214; Fungi - 180; Plants - 140; Viruses - 3; Other Eukaryotes - 255 (source: NCBI BLink).
    NP_195383.1
    • plant-specific TFIIB-related protein (PBRP); FUNCTIONS IN: RNA polymerase II transcription factor activity, rDNA binding; INVOLVED IN: translational initiation, regulation of transcription, DNA-dependent, transcription initiation; LOCATED IN: plastid outer membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor TFIIB related (InterPro:IPR000812), Transcription factor TFIIB, cyclin-related (InterPro:IPR013150), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: transcription factor IIB (TAIR:AT2G41630.1); Has 1560 Blast hits to 1559 proteins in 341 species: Archae - 524; Bacteria - 1; Metazoa - 239; Fungi - 259; Plants - 166; Viruses - 3; Other Eukaryotes - 368 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17283033..17285656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119828.6 → NP_195383.1  plant-specific TFIIB-related protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23215
      UniProtKB/TrEMBL
      A0A178V193
      Conserved Domains (2) summary
      COG1405
      Location:132 → 313
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:233 → 311
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. NM_001085033.4 → NP_001078502.4  plant-specific TFIIB-related protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078502.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MR42
      Conserved Domains (2) summary
      COG1405
      Location:132 → 300
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:233 → 304
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23215.1

    Gene LinkOut

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