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    5-FCL 5-formyltetrahydrofolate cycloligase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831144, updated on 18-Sep-2024

    Summary

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    Official Symbol
    5-FCL
    Official Full Name
    5-formyltetrahydrofolate cycloligase
    Primary source
    TAIR:AT5G13050
    Locus tag
    AT5G13050
    See related
    Araport:AT5G13050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    5-CHO-THF CYCLOLIGASE; 5-formyltetrahydrofolate cycloligase; T19L5.10; T19L5_10
    Summary
    5-Formyltetrahydrofolate cycloligase (5-CHO-THF cycloligase - AT5G13050.1) regulates/influences under photorespiratory conditions the activity of another gene product, i.e. serine hydroxymethyltransferase (SHMT) due to accumulating amounts of 5-Formyltetrahydrofolate
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    Genomic context

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    See 5-FCL in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (4136556..4138792, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RNA helicase family protein Neighboring gene Emsy N Terminus (ENT)/ plant Tudor-like domains-containing protein Neighboring gene selenoprotein O Neighboring gene ARMADILLO BTB protein 1 Neighboring gene MSF1-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves. Goyer A, et al. J Biol Chem, 2005 Jul 15. PMID 15888445
    2. Cloning and characterization of mitochondrial 5-formyltetrahydrofolate cycloligase from higher plants. Roje S, et al. J Biol Chem, 2002 Nov 8. PMID 12207015
    3. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. Yoo H, et al. Mol Plant, 2020 Jan 6. PMID 31568832, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001036796.2
    NM_121308.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 5-formyltetrahydrofolate cyclo-ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5-formyltetrahydrofolate cyclo-ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within tetrahydrofolate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-formyltetrahydrofolate cycloligase
    NP_001031873.1
    • 5-formyltetrahydrofolate cycloligase (5-FCL); CONTAINS InterPro DOMAIN/s: 5-formyltetrahydrofolate cyclo-ligase (InterPro:IPR002698); Has 1110 Blast hits to 1110 proteins in 558 species: Archae - 4; Bacteria - 853; Metazoa - 105; Fungi - 55; Plants - 43; Viruses - 0; Other Eukaryotes - 50 (source: NCBI BLink).
    NP_568284.1
    • 5-formyltetrahydrofolate cycloligase (5-FCL); CONTAINS InterPro DOMAIN/s: 5-formyltetrahydrofolate cyclo-ligase (InterPro:IPR002698); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4136556..4138792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121308.2 → NP_568284.1  5-formyltetrahydrofolate cycloligase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568284.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K2F3, Q84WD9, Q8L539, Q9FYA5
      UniProtKB/TrEMBL
      A0A178UBC3, A0A654G0R0
      Conserved Domains (1) summary
      PLN02812
      Location:54 → 267
      PLN02812; 5-formyltetrahydrofolate cyclo-ligase

    2. NM_001036796.2 → NP_001031873.1  5-formyltetrahydrofolate cycloligase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UD81
      Conserved Domains (1) summary
      PLN02812
      Location:54 → 208
      PLN02812; 5-formyltetrahydrofolate cyclo-ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L539.1

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