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    MRPS35 mitochondrial ribosomal protein S35 [ Homo sapiens (human) ]

    Gene ID: 60488, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MRPS35provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S35provided by HGNC
    Primary source
    HGNC:HGNC:16635
    See related
    Ensembl:ENSG00000061794 MIM:611995; AllianceGenome:HGNC:16635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mS35; MDS023; MRPS28; MRP-S28; HDCMD11P
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in kidney (RPKM 30.7), colon (RPKM 30.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MRPS35 in Genome Data Viewer
    Location:
    12p11.22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (27710832..27756295)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (27582568..27628010)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27863765..27909228)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MRPS35 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:27857921-27858432 Neighboring gene RAB15 effector protein Neighboring gene high mobility group box 1 pseudogene 49 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:27904053-27904827 Neighboring gene MANSC domain containing 4 Neighboring gene MPRA-validated peak1632 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4313 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:27933183-27933682 Neighboring gene kelch like family member 42 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_27127 Neighboring gene RN7SK pseudogene 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Circular RNA circMRPS35 represses malignant progression in osteosarcoma cells via targeting miR-105-5p/FOXO1. Jiang C, et al. Aging (Albany NY), 2024 Aug 5. PMID 39103205, Free PMC Article
    2. ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. Ishiguchi H, et al. Int J Cancer, 2004 Oct 10. PMID 15300802
    3. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. Koc EC, et al. Protein Sci, 2001 Mar. PMID 11344316, Free PMC Article
    4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634
    5. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA circMRPS35 represses malignant progression in osteosarcoma cells via targeting miR-105-5p/FOXO1.
      Title: Circular RNA circMRPS35 represses malignant progression in osteosarcoma cells via targeting miR-105-5p/FOXO1.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC104278, DKFZp762P093

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS35
    Names
    28S ribosomal protein S28, mitochondrial
    28S ribosomal protein S35, mitochondrial
    MRP-S35
    S28mt
    S35mt
    mitochondrial ribosomal protein S28
    mitochondrial small ribosomal subunit protein mS35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190864.2 → NP_001177793.1  small ribosomal subunit protein mS35 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001177793.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK075378, BC015862, DA747094
      Consensus CDS
      CCDS53769.1
      UniProtKB/TrEMBL
      H0YG82
      Related
      ENSP00000445390.1, ENST00000538315.5

    2. NM_021821.4 → NP_068593.2  small ribosomal subunit protein mS35 isoform 1 precursor

      See identical proteins and their annotated locations for NP_068593.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC015862, DA747094
      Consensus CDS
      CCDS8714.1
      UniProtKB/Swiss-Prot
      P82673, Q32LZ1, Q6P4C6, Q7L1M6, Q8NBP4, Q96AI0, Q9H044, Q9HC14, Q9P1R5
      Related
      ENSP00000081029.3, ENST00000081029.8
      Conserved Domains (1) summary
      cl40670
      Location:148 → 251
      PCRF; PCRF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      27710832..27756295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019780.2 → XP_016875269.1  small ribosomal subunit protein mS35 isoform X1

      UniProtKB/TrEMBL
      H0YG82
      Related
      ENSP00000442137.1, ENST00000542199.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      27582568..27628010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372826.1 → XP_054228801.1  small ribosomal subunit protein mS35 isoform X1

      UniProtKB/TrEMBL
      H0YG82
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82673.1 GenPept UniProtKB/Swiss-Prot:P82673

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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