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    scyl-1 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scyl-1
    Official Full Name
    Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00012337
    Locus tag
    CELE_W07G4.3
    See related
    AllianceGenome:WB:WBGene00012337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kinase activity. Is expressed in excretory cell; intestinal cell; spermatheca; uterine epithelial cell; and ventral cord neurons. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 21. Orthologous to human SCYL1 (SCY1 like pseudokinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scyl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (13036894..13041721, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Secretory peptide Neighboring gene L-Fucosyltransferase Neighboring gene ncRNA Neighboring gene Putative aminopeptidase W07G4.4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Slo2 potassium channel function depends on RNA editing-regulated expression of a SCYL1 protein. Niu LG, et al. Elife, 2020 Apr 21. PMID 32314960, Free PMC Article
    2. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
    3. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein
    NP_001366843.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13036894..13041721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380793.3 → NP_001366843.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23215
      Conserved Domains (3) summary
      sd00044
      Location:313 → 337
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:446 → 492
      HEAT_EZ; HEAT-like repeat
      cl21453
      Location:58 → 165
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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