Dynlrb1 dynein light chain roadblock-type 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dynlrb1provided by MGI
Official Full Name: dynein light chain roadblock-type 1provided by MGI
Primary source: MGI:MGI:1914318
See related: Ensembl:ENSMUSG00000047459 AllianceGenome:MGI:1914318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DNLC2A; Dncl2a; km23-1; 2010012N15Rik; 2010320M17Rik; 9430076K19Rik
Summary: Enables identical protein binding activity. Predicted to be involved in microtubule-based movement and visual behavior. Part of cytoplasmic dynein complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; and retina. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 150.1), whole brain E14.5 (RPKM 121.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.07 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (155078453..155092197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (155236533..155250277)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.
Title: Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.
N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
Title: N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
The presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner.
Title: Cautionary tail: the presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in visual behavior	ISO Inferred from Sequence Orthology more info
involved_in visual behavior	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IDA Inferred from Direct Assay more info	PubMed
part_of dynein complex	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein light chain roadblock-type 1

Names: dynein light chain 2A, cytoplasmic; dynein, cytoplasmic, light chain 2A; dynein, cytoplasmic, light polypeptide 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291108.1 → NP_001278037.1 dynein light chain roadblock-type 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

CJ136086, CO041603

Consensus CDS

CCDS71166.1

UniProtKB/TrEMBL

A2AVR9

Related

ENSMUSP00000114928.2, ENSMUST00000150602.2

Conserved Domains (1) summary

smart00960
Location:12 → 99

Robl_LC7; Roadblock/LC7 domain
NM_025947.3 → NP_080223.2 dynein light chain roadblock-type 1 isoform b

See identical proteins and their annotated locations for NP_080223.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AK166685, AL929588, CO041603

Consensus CDS

CCDS38294.1

UniProtKB/Swiss-Prot

A2AVR8, O88567, P62627, Q4FZJ8, Q9D812

Related

ENSMUSP00000105304.3, ENSMUST00000109682.9

Conserved Domains (1) summary

smart00960
Location:4 → 91

Robl_LC7; Roadblock/LC7 domain

RNA

NR_111890.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in its 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL929588, CJ136086, CO041603
NR_111891.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK002359, AL929588, CO041603

Related

ENSMUST00000054912.15