Bmx BMX non-receptor tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmxprovided by MGI
Official Full Name: BMX non-receptor tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:1101778
See related: Ensembl:ENSMUSG00000031377 AllianceGenome:MGI:1101778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Etk; Tyro8; Etk/Bmx
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and protein autophosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; hemolymphoid system; and mammary gland. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 1.1), lung adult (RPKM 0.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F5; X 76.12 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (162975838..163041189, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (164192842..164258193, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx.
Title: Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx.
Data show that bone marrow kinase on the X chromosome (BMX) specifically repressed thrombin-PAR1 (protease-activated receptor-1) signaling in endothelial cells by directly phosphorylating PAR1 and promoting its internalization and deactivation.
Title: BMX Represses Thrombin-PAR1-Mediated Endothelial Permeability and Vascular Leakage During Early Sepsis.
results suggest that the endothelial Bmx tyrosine kinase could provide a target to attenuate the development of cardiac hypertrophy
Title: Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.
Btk, Tec, Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
Title: The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
Title: Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
Our findings therefore indicate that Bmx activity contributes to tumor angiogenesis and growth.
Title: Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.
genetic ablation of BMX conferred protection in arthritis model confirming BMX an essential mediator of inflammation in vivo; conclude BMX an essential component of inflammatory cytokine signaling and catalytic as well noncatalytic functions are involved
Title: The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner.
Investigate Bmx mediates VEGF-dependent lymphangiogenic signaling.
Title: Functional analyses of the bone marrow kinase in the X chromosome in vascular endothelial growth factor-induced lymphangiogenesis.
by preventing binding of Etk/Bmx to PAR(1) -C-tail, hPar1 oncogenic properties are abrogated
Title: Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance.
activation of Etk largely co-localizes with TNFR2 in vascular endothelial cells and cardiomyocytes.
Title: TNF receptors differentially signal and are differentially expressed and regulated in the human heart.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-31e7 (e-PCR)
- UniSTS:258374

U88091 (e-PCR)
- UniSTS:186191

px-24c3 (e-PCR)
- UniSTS:257449

DXMit122 (e-PCR), detects polymorphism
- UniSTS:132013

Bmx (e-PCR), detects polymorphism
- UniSTS:265214

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoplasmic tyrosine-protein kinase BMX

Names: TYRO8 protein tyrosine kinase 8; bone marrow tyrosine kinase gene in chromosome X protein homolog

NP_033889.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009759.4 → NP_033889.2 cytoplasmic tyrosine-protein kinase BMX

Status: VALIDATED

Source sequence(s)

AK036707, AK040936

Consensus CDS

CCDS30519.2

UniProtKB/Swiss-Prot

P97504

UniProtKB/TrEMBL

B1AUL5, B1AUL6

Related

ENSMUSP00000107884.3, ENSMUST00000112265.9

Conserved Domains (5) summary

cd10399
Location:269 → 374

SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx

cd01238
Location:25 → 151

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

pfam00169
Location:27 → 115

PH; PH domain

pfam07714
Location:397 → 646

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:392 → 647

PKc_like; Protein Kinases, catalytic domain