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    Pnp2 purine-nucleoside phosphorylase 2 [ Mus musculus (house mouse) ]

    Gene ID: 667034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pnp2provided by MGI
    Official Full Name
    purine-nucleoside phosphorylase 2provided by MGI
    Primary source
    MGI:MGI:3712328
    See related
    Ensembl:ENSMUSG00000068417 AllianceGenome:MGI:3712328
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including heterocyclic compound binding activity; phosphate ion binding activity; and purine-nucleoside phosphorylase activity. Predicted to be involved in several processes, including nucleoside catabolic process; positive regulation of interleukin-2 production; and purine-containing compound salvage. Predicted to be located in cytosol and extracellular region. Predicted to be active in cytoplasm. Is expressed in alimentary system and intestine. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 65.1), small intestine adult (RPKM 32.2) and 17 other tissues See more
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    Genomic context

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    See Pnp2 in Genome Data Viewer
    Location:
    14 C1; 14 26.32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51193598..51202206)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50956141..50964751)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36659 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7308 Neighboring gene predicted gene, 52117 Neighboring gene purine-nucleoside phosphorylase Neighboring gene predicted gene, 38316 Neighboring gene STARR-seq mESC enhancer starr_36663 Neighboring gene predicted gene 8518 Neighboring gene ribonuclease, RNase A family, 10 (non-active)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior. Fan KQ, et al. Cell, 2019 Oct 31. PMID 31675497
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine nucleobase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inosine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nicotinamide riboside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleobase-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine-containing compound salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    purine-nucleoside phosphorylase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123371.2 → NP_001116843.1  purine-nucleoside phosphorylase 2

      See identical proteins and their annotated locations for NP_001116843.1

      Status: PROVISIONAL

      Source sequence(s)
      AK008143
      Consensus CDS
      CCDS49479.1
      UniProtKB/Swiss-Prot
      P23492, Q4FJT6
      UniProtKB/TrEMBL
      Q9D8C9
      Related
      ENSMUSP00000093615.5, ENSMUST00000095925.5
      Conserved Domains (2) summary
      COG0005
      Location:26 → 291
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      TIGR01700
      Location:41 → 295
      PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51193598..51202206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245151.4 → XP_011243453.2  purine-nucleoside phosphorylase 2 isoform X1

      UniProtKB/Swiss-Prot
      P23492, Q4FJT6
      Conserved Domains (1) summary
      cd09009
      Location:55 → 323
      PNP-EcPNPII_like; purine nucleoside phosphorylases similar to human PNP and Escherichia coli PNP-II (XapA)
    Nucleotide Protein Strain
    Heading Accession and Version

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