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    Atosa atos homolog A [ Mus musculus (house mouse) ]

    Gene ID: 235493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atosaprovided by MGI
    Official Full Name
    atos homolog Aprovided by MGI
    Primary source
    MGI:MGI:2387648
    See related
    Ensembl:ENSMUSG00000034858 AllianceGenome:MGI:2387648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam214a; Kiaa1370; mKIAA1370; 6330415I01Rik; C130047D21Rik
    Summary
    Predicted to be located in nucleus. Is expressed in several structures, including cerebral cortex; endocrine gland; hindlimb mesenchyme; jaw; and testis. Orthologous to human ATOSA (atos homolog A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 5.9), frontal lobe adult (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atosa in Genome Data Viewer
    Location:
    9 D; 9 42.12 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (74860162..74939750)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (74952867..75032468)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33562 Neighboring gene STARR-seq mESC enhancer starr_24650 Neighboring gene predicted gene 16551 Neighboring gene one cut domain, family member 1 Neighboring gene predicted gene, 38678 Neighboring gene STARR-positive B cell enhancer ABC_E8300 Neighboring gene STARR-positive B cell enhancer ABC_E6765 Neighboring gene STARR-positive B cell enhancer ABC_E714 Neighboring gene STARR-positive B cell enhancer mm9_chr9:74812784-74813085 Neighboring gene STARR-positive B cell enhancer mm9_chr9:74813338-74813639 Neighboring gene microRNA 1970c Neighboring gene STARR-seq mESC enhancer starr_24651 Neighboring gene STARR-seq mESC enhancer starr_24653 Neighboring gene STARR-positive B cell enhancer ABC_E10563 Neighboring gene predicted gene, 51714 Neighboring gene cAMP-regulated phosphoprotein 19 Neighboring gene apoptosis inhibitor 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models. Soulez M, et al. Mol Cell Biol, 2019 Mar 15. PMID 30642949, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38960, MGC41344

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    atos homolog protein A
    Names
    family with sequence similarity 214, member A
    protein FAM214A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113283.1 → NP_001106754.1  atos homolog protein A isoform 1

      See identical proteins and their annotated locations for NP_001106754.1

      Status: VALIDATED

      Source sequence(s)
      CT025657, CT033761
      Consensus CDS
      CCDS52857.1
      UniProtKB/Swiss-Prot
      E9PX00, Q69ZK7, Q8K0I6, Q8K266
      UniProtKB/TrEMBL
      A0AAQ4VMU4
      Related
      ENSMUSP00000129319.2, ENSMUST00000170846.9
      Conserved Domains (2) summary
      pfam13915
      Location:878 → 935
      DUF4210; Domain of unknown function (DUF4210)
      pfam13889
      Location:1017 → 1074
      Chromosome_seg; Chromosome segregation during meiosis

    2. NM_001359816.1 → NP_001346745.1  atos homolog protein A isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025657, CT033761
      Consensus CDS
      CCDS52857.1
      UniProtKB/Swiss-Prot
      E9PX00, Q69ZK7, Q8K0I6, Q8K266
      UniProtKB/TrEMBL
      A0AAQ4VMU4
      Conserved Domains (2) summary
      pfam13915
      Location:878 → 935
      DUF4210; Domain of unknown function (DUF4210)
      pfam13889
      Location:1017 → 1074
      Chromosome_seg; Chromosome segregation during meiosis

    3. NM_153584.2 → NP_705812.2  atos homolog protein A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AW990238, BC031353, BU057452
      Consensus CDS
      CCDS52858.1
      UniProtKB/TrEMBL
      A0AAQ4VMU4
      Related
      ENSMUSP00000080442.6, ENSMUST00000081746.7
      Conserved Domains (2) summary
      pfam13889
      Location:1024 → 1081
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:885 → 942
      DUF4210; Domain of unknown function (DUF4210)

    RNA

    1. NR_153342.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT025657, CT033761

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      74860162..74939750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511126.5 → XP_006511189.1  atos homolog protein A isoform X1

      See identical proteins and their annotated locations for XP_006511189.1

      UniProtKB/Swiss-Prot
      E9PX00, Q69ZK7, Q8K0I6, Q8K266
      UniProtKB/TrEMBL
      A0AAQ4VMU4
      Related
      ENSMUSP00000149021.2, ENSMUST00000215370.3
      Conserved Domains (2) summary
      pfam13915
      Location:878 → 935
      DUF4210; Domain of unknown function (DUF4210)
      pfam13889
      Location:1017 → 1074
      Chromosome_seg; Chromosome segregation during meiosis

    2. XM_036154910.1 → XP_036010803.1  atos homolog protein A isoform X2

      UniProtKB/TrEMBL
      A0AAQ4VMU4
      Conserved Domains (2) summary
      pfam13889
      Location:929 → 986
      Chromosome_seg; Chromosome segregation during meiosis
      pfam13915
      Location:790 → 847
      DUF4210; Domain of unknown function (DUF4210)

    RNA

    1. XR_001778884.3 RNA Sequence

    2. XR_379417.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZK7.3 GenPept UniProtKB/Swiss-Prot:Q69ZK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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