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    Spag11b sperm associated antigen 11B [ Mus musculus (house mouse) ]

    Gene ID: 546038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spag11bprovided by MGI
    Official Full Name
    sperm associated antigen 11Bprovided by MGI
    Primary source
    MGI:MGI:3647173
    See related
    Ensembl:ENSMUSG00000059463 AllianceGenome:MGI:3647173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ep2e; Bin1b; Ep2c/h; Spag11; EG546038; Spag11c/h
    Summary
    Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and cytolysis by host of symbiont cells. Predicted to be located in extracellular region. Orthologous to human SPAG11B (sperm associated antigen 11B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 854.9) See more
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    Genomic context

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    See Spag11b in Genome Data Viewer
    Location:
    8 A1.3; 8 10.35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (19190775..19193026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (19140759..19143010)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin beta 12 Neighboring gene defensin beta 34 Neighboring gene sperm associated antigen 11A Neighboring gene predicted gene, 53432

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Patil AA, et al. Physiol Genomics, 2005 Sep 21. PMID 16033865
    2. Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. Amid C, et al. BMC Genomics, 2009 Dec 15. PMID 20003482, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytolysis by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm-associated antigen 11B
    Names
    Sperm-associated antigen 11
    beta-defensin-like peptide
    sperm-associated antigen 11c/h

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034905.2 → NP_001030077.1  sperm-associated antigen 11B isoform 3 precursor

      See identical proteins and their annotated locations for NP_001030077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also called h) includes a 3' terminal exon which extends past a splice site that is used in variant 1. It encodes isoform 3 (also called h) which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK136627
      Consensus CDS
      CCDS40251.1
      UniProtKB/TrEMBL
      Q3UW43
      Related
      ENSMUSP00000106395.2, ENSMUST00000110767.2
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 71
      Sperm_Ag_HE2; Sperm antigen HE2

    2. NM_001039563.3 → NP_001034652.2  sperm-associated antigen 11B isoform c precursor

      See identical proteins and their annotated locations for NP_001034652.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform 1.
      Source sequence(s)
      AK136627, DQ012055
      Consensus CDS
      CCDS22133.1
      UniProtKB/Swiss-Prot
      Q2HPE2, Q3UW43
      UniProtKB/TrEMBL
      Q2HPE3
      Related
      ENSMUSP00000048125.8, ENSMUST00000039075.8
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 72
      Sperm_Ag_HE2; Sperm antigen HE2

    3. NM_001286493.1 → NP_001273422.1  sperm-associated antigen 11B isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AC116394, AK136627, DQ012055
      UniProtKB/TrEMBL
      B7ZNZ8
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 73
      Sperm_Ag_HE2; Sperm antigen HE2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      19190775..19193026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UW43.2 GenPept UniProtKB/Swiss-Prot:Q3UW43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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