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    ZNF16 zinc finger protein 16 [ Homo sapiens (human) ]

    Gene ID: 7564, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF16provided by HGNC
    Official Full Name
    zinc finger protein 16provided by HGNC
    Primary source
    HGNC:HGNC:12947
    See related
    Ensembl:ENSG00000170631 MIM:601262; AllianceGenome:HGNC:12947
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HZF1; KOX9
    Summary
    The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 5.1), testis (RPKM 4.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF16 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144930358..144950880, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (146104378..146126046, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146155744..146176266, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:146064238-146064791 Neighboring gene zinc finger protein 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:146076290-146076441 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146077648-146078496 Neighboring gene COMM domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28109 Neighboring gene zinc finger protein 250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126184-146126788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126789-146127391 Neighboring gene uncharacterized LOC124902042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146127392-146127995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28110 Neighboring gene zinc finger protein 252, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:146228590-146229166 Neighboring gene ZNF252P antisense RNA 1 Neighboring gene transmembrane p24 trafficking protein 10 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. Dreier B, et al. J Mol Biol, 2000 Nov 3. PMID 11054286
    2. Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population. Zhang H, et al. J Pathol, 2020 Aug. PMID 32432340
    3. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). Deng MJ, et al. Mol Biotechnol, 2010 Feb. PMID 19763908
    4. Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. Ahn SW, et al. Diagn Pathol, 2020 May 27. PMID 32460791, Free PMC Article
    5. Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells. Peng H, et al. Leukemia, 2006 Jun. PMID 16628192

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma.
      Title: Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma.
    2. Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population.
      Title: Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population.
    3. study demonstrate that ZNF16 plays an important role in erythropoiesis and megakaryocytopoiesis via its regulation of the c-Kit/c-Raf/MEK/ERK/c-Jun/HEY1/GATA1 cascade
      Title: ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via regulation of the c-KIT gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to sodium dodecyl sulfate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle phase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 16
    Names
    zinc finger protein KOX9
    zinc finger protein Kruppel type 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029976.3 → NP_001025147.2  zinc finger protein 16 isoform 1

      See identical proteins and their annotated locations for NP_001025147.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript variant and encodes the same protein, as compared to transcript variant 1.
      Source sequence(s)
      BC010996, DQ117529
      Consensus CDS
      CCDS6437.1
      UniProtKB/Swiss-Prot
      B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4
      Related
      ENSP00000276816.4, ENST00000276816.8
      Conserved Domains (2) summary
      COG5048
      Location:303 → 675
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:323 → 343
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001413564.1 → NP_001400493.1  zinc finger protein 16 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AF235103
      UniProtKB/Swiss-Prot
      B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4

    3. NM_001413565.1 → NP_001400494.1  zinc finger protein 16 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AF235103
      UniProtKB/Swiss-Prot
      B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4

    4. NM_001413566.1 → NP_001400495.1  zinc finger protein 16 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AF235103
      UniProtKB/Swiss-Prot
      B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4

    5. NM_001413567.1 → NP_001400496.1  zinc finger protein 16 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AF235103

    6. NM_006958.3 → NP_008889.2  zinc finger protein 16 isoform 1

      See identical proteins and their annotated locations for NP_008889.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon in the 5' UTR and encodes the same protein, as compared to transcript variant 2.
      Source sequence(s)
      AF244088, AK127625
      Consensus CDS
      CCDS6437.1
      UniProtKB/Swiss-Prot
      B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4
      Related
      ENSP00000378369.2, ENST00000394909.7
      Conserved Domains (2) summary
      COG5048
      Location:303 → 675
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:323 → 343
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144930358..144950880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      146104378..146126046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17020.3 GenPept UniProtKB/Swiss-Prot:P17020

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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