NLRX1 NLR family member X1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NLRX1provided by HGNC
Official Full Name: NLR family member X1provided by HGNC
Primary source: HGNC:HGNC:29890
See related: Ensembl:ENSG00000160703 MIM:611947; AllianceGenome:HGNC:29890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NOD5; NOD9; NOD26; DLNB26; CLR11.3
Summary: The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
Expression: Ubiquitous expression in esophagus (RPKM 15.5), skin (RPKM 7.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (119168334..119184016)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (119188702..119204385)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (119039043..119054725)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway.
Title: NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway.
NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.
Title: NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression.
NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.
Title: NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.
NLRX1 increases human retinal pigment epithelial autophagy and reduces H2O2-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.
Title: NLRX1 increases human retinal pigment epithelial autophagy and reduces H(2)O(2)-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.
The regulatory role of NLRX1 in innate immunity and human disease.
Title: The regulatory role of NLRX1 in innate immunity and human disease.
NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.
Title: NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.
Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.
Title: Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.
MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1.
Title: MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1.
Focusing on the Cell Type Specific Regulatory Actions of NLRX1.
Title: Focusing on the Cell Type Specific Regulatory Actions of NLRX1.
Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism.
Title: Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of NLR family member X1 (NLRX1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-16056 (e-PCR)
- UniSTS:53534

G17564 (e-PCR)
- UniSTS:4521

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: NLR family member X1

Names: NOD-like receptor X1; caterpiller protein 11.3; nucleotide-binding oligomerization domain protein 26; nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain, leucine rich repeat containing X1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047185.1 RefSeqGene

Range

5392..20683

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001282143.2 → NP_001269072.1 NLR family member X1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001269072.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. All three variants encode the same protein.

Source sequence(s)

AB094095, BX647705, DA107044

Consensus CDS

CCDS8416.1

UniProtKB/Swiss-Prot

A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

UniProtKB/TrEMBL

A0A9L9PXS9

Related

ENSP00000386851.1, ENST00000409991.5

Conserved Domains (3) summary

cd00116
Location:698 → 885

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:698 → 726

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:161 → 320

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001282144.2 → NP_001269073.1 NLR family member X1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001269073.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AB094095, BC110890, DA107044

Consensus CDS

CCDS8416.1

UniProtKB/Swiss-Prot

A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

UniProtKB/TrEMBL

A0A9L9PXS9

Related

ENSP00000387334.1, ENST00000409109.6

Conserved Domains (3) summary

cd00116
Location:698 → 885

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:698 → 726

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:161 → 320

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001282358.2 → NP_001269287.1 NLR family member X1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001269287.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. All variants encode the same protein.

Source sequence(s)

AB094095, AP002956, DA441499

Consensus CDS

CCDS8416.1

UniProtKB/Swiss-Prot

A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

UniProtKB/TrEMBL

A0A9L9PXS9

Conserved Domains (3) summary

cd00116
Location:698 → 885

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:698 → 726

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:161 → 320

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_024618.4 → NP_078894.2 NLR family member X1 isoform 1 precursor

See identical proteins and their annotated locations for NP_078894.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. All three variants encode the same protein.

Source sequence(s)

AB094095, DA107044

Consensus CDS

CCDS8416.1

UniProtKB/Swiss-Prot

A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

UniProtKB/TrEMBL

A0A9L9PXS9

Related

ENSP00000292199.2, ENST00000292199.6

Conserved Domains (3) summary

cd00116
Location:698 → 885

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:698 → 726

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:161 → 320

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_170722.2 → NP_733840.1 NLR family member X1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AP002956

Consensus CDS

CCDS44752.1

UniProtKB/TrEMBL

A0A9L9PXS9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

119168334..119184016

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011542980.2 → XP_011541282.1 NLR family member X1 isoform X1

See identical proteins and their annotated locations for XP_011541282.1

UniProtKB/Swiss-Prot

A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

UniProtKB/TrEMBL

A0A9L9PXS9

Conserved Domains (3) summary

cd00116
Location:698 → 885

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:698 → 726

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:161 → 320

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006718904.2 → XP_006718967.1 NLR family member X1 isoform X2

UniProtKB/TrEMBL

A0A9L9PXS9

Conserved Domains (3) summary

cd00116
Location:698 → 850

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:698 → 726

LRR_AMN1; leucine-rich repeat [structural motif]

cl21455
Location:161 → 320

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_005271669.2 → XP_005271726.1 NLR family member X1 isoform X1

See identical proteins and their annotated locations for XP_005271726.1

UniProtKB/Swiss-Prot

A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

UniProtKB/TrEMBL

A0A9L9PXS9

Related

ENSP00000516519.1, ENST00000706729.1

Conserved Domains (3) summary

cd00116
Location:698 → 885

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:698 → 726

LRR_RI; leucine-rich repeat [structural motif]

cl21455
Location:161 → 320

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_047427586.1 → XP_047283542.1 NLR family member X1 isoform X2

UniProtKB/TrEMBL

A0A9L9PXS9
XM_047427587.1 → XP_047283543.1 NLR family member X1 isoform X2

UniProtKB/TrEMBL

A0A9L9PXS9

Related

ENSP00000433442.1, ENST00000525863.1
XM_047427589.1 → XP_047283545.1 NLR family member X1 isoform X3

UniProtKB/TrEMBL

A0A9L9PX86, A0A9L9PXS9

Related

ENSP00000516517.1, ENST00000706728.1