U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked [ Mus musculus (house mouse) ]

    Gene ID: 22290, updated on 3-Dec-2024

    Summary

    Official Symbol
    Utyprovided by MGI
    Official Full Name
    ubiquitously transcribed tetratricopeptide repeat containing, Y-linkedprovided by MGI
    Primary source
    MGI:MGI:894810
    See related
    Ensembl:ENSMUSG00000068457 AllianceGenome:MGI:894810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hydb; mKIAA4057
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone H3K36 demethylase activity. Acts upstream of or within several processes, including cardiac muscle cell contraction; heterochromatin formation; and in utero embryonic development. Part of protein-containing complex. Is expressed in several structures, including alimentary system; early conceptus; forelimb bud; genitourinary system; and liver. Orthologous to human UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 1.8), CNS E14 (RPKM 1.7) and 18 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Uty in Genome Data Viewer
    Location:
    Y; Ypter
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1085187..1245787, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1085187..1245773, complement)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Neighboring gene STARR-seq mESC enhancer starr_48297 Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene STARR-seq mESC enhancer starr_48298 Neighboring gene DEAD box helicase 3, Y-linked Neighboring gene predicted gene 4017 Neighboring gene ring finger and WD repeat domain 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4057

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K27me2/H3K27me3 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K27me2/H3K27me3 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone demethylase UTY
    Names
    [histone H3]-trimethyl-L-lysine(27) demethylase UTY
    male-specific histocompatibility antigen H-YDB
    ubiquitously transcribed TPR protein on the Y chromosome
    ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
    ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
    NP_001313611.1
    NP_001313612.1
    NP_001406755.1
    NP_001406756.1
    NP_001406757.1
    NP_001406758.1
    NP_001406759.1
    NP_033510.2
    XP_006531650.1
    XP_011246883.1
    XP_011246884.1
    XP_011246885.1
    XP_011246886.1
    XP_011246887.1
    XP_011246888.1
    XP_011246891.1
    XP_017174175.1
    XP_017174176.1
    XP_017174177.1
    XP_017174178.1
    XP_030107425.1
    XP_036018083.1
    XP_036018084.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326682.2NP_001313611.1  histone demethylase UTY isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      Consensus CDS
      CCDS85834.1
      UniProtKB/Swiss-Prot
      O97979, P79457
      UniProtKB/TrEMBL
      E9PWW8
      Related
      ENSMUSP00000114752.2, ENSMUST00000139365.8
      Conserved Domains (7) summary
      pfam02373
      Location:9441052
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:910974
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:279306
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:124157
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:311372
      TPR_11; TPR repeat
      pfam13424
      Location:274342
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:266297
      TPR_17; Tetratricopeptide repeat
    2. NM_001326683.2NP_001313612.1  histone demethylase UTY isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      Consensus CDS
      CCDS85833.1
      UniProtKB/Swiss-Prot
      O97979, P79457
      UniProtKB/TrEMBL
      Q3UQE8
      Related
      ENSMUSP00000114910.2, ENSMUST00000154004.8
      Conserved Domains (7) summary
      pfam02373
      Location:882990
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:848912
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:217244
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:6295
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:249310
      TPR_11; TPR repeat
      pfam13424
      Location:212280
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:204235
      TPR_17; Tetratricopeptide repeat
    3. NM_001419826.1NP_001406755.1  histone demethylase UTY isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      UniProtKB/Swiss-Prot
      O97979, P79457
    4. NM_001419827.1NP_001406756.1  histone demethylase UTY isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      UniProtKB/Swiss-Prot
      O97979, P79457
    5. NM_001419828.1NP_001406757.1  histone demethylase UTY isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      UniProtKB/Swiss-Prot
      O97979, P79457
    6. NM_001419829.1NP_001406758.1  histone demethylase UTY isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      UniProtKB/Swiss-Prot
      O97979, P79457
    7. NM_001419830.1NP_001406759.1  histone demethylase UTY isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      UniProtKB/Swiss-Prot
      O97979, P79457
    8. NM_009484.4NP_033510.2  histone demethylase UTY isoform 1

      See identical proteins and their annotated locations for NP_033510.2

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      Consensus CDS
      CCDS41216.1
      UniProtKB/Swiss-Prot
      O97979, P79457
      UniProtKB/TrEMBL
      G3X9F2
      Related
      ENSMUSP00000070012.8, ENSMUST00000069309.14
      Conserved Domains (7) summary
      pfam02373
      Location:9451053
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:911975
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:280307
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:125158
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:312373
      TPR_11; TPR repeat
      pfam13424
      Location:275343
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:267298
      TPR_17; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      1085187..1245787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248585.4XP_011246887.1  histone demethylase UTY isoform X9

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:935999
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:130397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304331
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9691077
      JmjC; JmjC domain, hydroxylase
    2. XM_011248583.2XP_011246885.1  histone demethylase UTY isoform X5

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:916980
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:111378
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9501058
      JmjC; JmjC domain, hydroxylase
    3. XM_036162190.1XP_036018083.1  histone demethylase UTY isoform X13

      UniProtKB/TrEMBL
      E9Q504
      Related
      ENSMUSP00000115113.2, ENSMUST00000143286.8
      Conserved Domains (4) summary
      smart00558
      Location:862926
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:97369
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:276303
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:8961004
      JmjC; JmjC domain, hydroxylase
    4. XM_011248582.4XP_011246884.1  histone demethylase UTY isoform X4

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:931995
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:126393
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:300327
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9651073
      JmjC; JmjC domain, hydroxylase
    5. XM_030251565.2XP_030107425.1  histone demethylase UTY isoform X15

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:848912
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:38310
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:217244
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:882990
      JmjC; JmjC domain, hydroxylase
    6. XM_011248581.4XP_011246883.1  histone demethylase UTY isoform X3

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:932996
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:127394
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:301328
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9661074
      JmjC; JmjC domain, hydroxylase
    7. XM_017318687.3XP_017174176.1  histone demethylase UTY isoform X2

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:934998
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:129396
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:303330
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9681076
      JmjC; JmjC domain, hydroxylase
    8. XM_017318688.3XP_017174177.1  histone demethylase UTY isoform X14

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:851915
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:41313
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:220247
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:885993
      JmjC; JmjC domain, hydroxylase
    9. XM_006531587.5XP_006531650.1  histone demethylase UTY isoform X18

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:886950
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:101373
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:280307
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9201028
      JmjC; JmjC domain, hydroxylase
    10. XM_011248586.4XP_011246888.1  histone demethylase UTY isoform X10

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:890954
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:130397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304331
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9241032
      JmjC; JmjC domain, hydroxylase
    11. XM_011248584.4XP_011246886.1  histone demethylase UTY isoform X6

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:910974
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:130397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304331
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9441052
      JmjC; JmjC domain, hydroxylase
    12. XM_017318686.3XP_017174175.1  histone demethylase UTY isoform X1

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:935999
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:130397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304331
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:9691077
      JmjC; JmjC domain, hydroxylase
    13. XM_036162191.1XP_036018084.1  histone demethylase UTY isoform X17

      UniProtKB/TrEMBL
      Q3TNX2
      Conserved Domains (2) summary
      smart00558
      Location:448512
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02373
      Location:482590
      JmjC; JmjC domain, hydroxylase
    14. XM_017318689.2XP_017174178.1  histone demethylase UTY isoform X17

      UniProtKB/TrEMBL
      Q3TNX2
      Conserved Domains (2) summary
      smart00558
      Location:448512
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02373
      Location:482590
      JmjC; JmjC domain, hydroxylase
    15. XM_011248589.4XP_011246891.1  histone demethylase UTY isoform X16

      Conserved Domains (2) summary
      COG0457
      Location:130397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304331
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_004940595.1 RNA Sequence

    2. XR_879400.4 RNA Sequence

    3. XR_004940593.1 RNA Sequence

    4. XR_004940592.1 RNA Sequence

    5. XR_001782882.3 RNA Sequence

      Related
      ENSMUST00000154666.8
    6. XR_004940594.1 RNA Sequence