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    Elmod2 ELMO/CED-12 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 244548, updated on 9-Dec-2024

    Summary

    Official Symbol
    Elmod2provided by MGI
    Official Full Name
    ELMO/CED-12 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2445165
    See related
    Ensembl:ENSMUSG00000035151 AllianceGenome:MGI:2445165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830169G11Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of defense response to virus. Is expressed in several structures, including adrenal gland; genitourinary system; gut gland; nervous system; and stomach. Orthologous to human ELMOD2 (ELMO domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 5.0), CNS E18 (RPKM 5.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Elmod2 in Genome Data Viewer
    Location:
    8 C2; 8 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84039261..84059115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83312632..83332490, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 9 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22078 Neighboring gene uncoupling protein 1 (mitochondrial, proton carrier) Neighboring gene STARR-seq mESC enhancer starr_22080 Neighboring gene STARR-positive B cell enhancer ABC_E1762 Neighboring gene predicted gene, 32327 Neighboring gene MGAT4 family, member C Neighboring gene cofilin 1, non-muscle pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables GTPase activator activity  

    General protein information

    Preferred Names
    ELMO domain-containing protein 2
    Names
    ELMO domain containing 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170691.1NP_001164162.1  ELMO domain-containing protein 2

      See identical proteins and their annotated locations for NP_001164162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122890, AK036607
      Consensus CDS
      CCDS22450.1
      UniProtKB/Swiss-Prot
      Q6AXC7, Q8BGF6, Q8BHP5
      Related
      ENSMUSP00000137044.2, ENSMUST00000177594.8
      Conserved Domains (1) summary
      pfam04727
      Location:110268
      ELMO_CED12; ELMO/CED-12 family
    2. NM_178736.5NP_848851.3  ELMO domain-containing protein 2

      See identical proteins and their annotated locations for NP_848851.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122890, AK084950
      Consensus CDS
      CCDS22450.1
      UniProtKB/Swiss-Prot
      Q6AXC7, Q8BGF6, Q8BHP5
      Related
      ENSMUSP00000052287.4, ENSMUST00000053902.4
      Conserved Domains (1) summary
      pfam04727
      Location:110268
      ELMO_CED12; ELMO/CED-12 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84039261..84059115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154033.1XP_036009926.1  ELMO domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXC7, Q8BGF6, Q8BHP5
      Conserved Domains (1) summary
      pfam04727
      Location:110268
      ELMO_CED12; ELMO/CED-12 family
    2. XM_006530979.4XP_006531042.1  ELMO domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531042.1

      UniProtKB/Swiss-Prot
      Q6AXC7, Q8BGF6, Q8BHP5
      Conserved Domains (1) summary
      pfam04727
      Location:110268
      ELMO_CED12; ELMO/CED-12 family

    RNA

    1. XR_004934824.1 RNA Sequence

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