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    B4galnt3 beta-1,4-N-acetyl-galactosaminyl transferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 330406, updated on 27-Nov-2024

    Summary

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    Official Symbol
    B4galnt3provided by MGI
    Official Full Name
    beta-1,4-N-acetyl-galactosaminyl transferase 3provided by MGI
    Primary source
    MGI:MGI:3041155
    See related
    Ensembl:ENSMUSG00000041372 AllianceGenome:MGI:3041155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B4GalNAcT3; C330047A21
    Summary
    Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi apparatus. Orthologous to human B4GALNT3 (beta-1,4-N-acetyl-galactosaminyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 15.3), kidney adult (RPKM 10.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B4galnt3 in Genome Data Viewer
    Location:
    6 F1; 6 56.94 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120177714..120271879, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120200753..120294917, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr6:119988697-119988998 Neighboring gene STARR-positive B cell enhancer ABC_E1708 Neighboring gene microRNA 706 Neighboring gene STARR-positive B cell enhancer ABC_E8832 Neighboring gene STARR-positive B cell enhancer ABC_E11333 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120061967-120062268 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120062467-120062768 Neighboring gene STARR-seq mESC enhancer starr_17160 Neighboring gene ninjurin 2 Neighboring gene STARR-positive B cell enhancer ABC_E2801 Neighboring gene STARR-positive B cell enhancer ABC_E2802 Neighboring gene STARR-positive B cell enhancer ABC_E10405 Neighboring gene predicted gene, 25327 Neighboring gene STARR-seq mESC enhancer starr_17164 Neighboring gene STARR-positive B cell enhancer ABC_E6477 Neighboring gene STARR-seq mESC enhancer starr_17178 Neighboring gene STARR-seq mESC enhancer starr_17179 Neighboring gene STARR-seq mESC enhancer starr_17181 Neighboring gene STARR-positive B cell enhancer ABC_E3675 Neighboring gene STARR-positive B cell enhancer ABC_E11334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120314296-120314483 Neighboring gene coiled-coil domain containing 77 Neighboring gene lysine demethylase 5A Neighboring gene predicted gene, 24592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. B4GALNT3 regulates glycosylation of sclerostin and bone mass. Movérare-Skrtic S, et al. EBioMedicine, 2023 May. PMID 37023531, Free PMC Article
    2. GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels. Gergei I, et al. Hum Mol Genet, 2022 Mar 3. PMID 34542150, Free PMC Article
    3. Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells. Huang J, et al. Mol Cancer Res, 2007 Jun. PMID 17579116
    4. Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc. Sato T, et al. J Biol Chem, 2003 Nov 28. PMID 12966086
    5. Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4. Fiete D, et al. J Biol Chem, 2012 Aug 17. PMID 22722940, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
      Title: Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.
    2. Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
      Title: Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.
    3. up-regulation of beta4GalNAc-T3 may play a critical role in promoting tumor malignanc
      Title: Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-N-acetylgalactosaminyltransferase 3
    Names
    N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2
    NGalNAc-T2
    beta 1,4-N-acetylgalactosaminyltransferase-transferase 3
    beta 1,4-N-acetylgalactosaminyltransferase-transferase-III
    beta-1,4-N-acetylgalactosaminyltransferase III
    beta4GalNAc-T3
    beta4GalNAcT3
    NP_942585.1
    XP_006506379.1
    XP_006506381.1
    XP_011239697.1
    XP_017177147.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198884.2 → NP_942585.1  beta-1,4-N-acetylgalactosaminyltransferase 3

      See identical proteins and their annotated locations for NP_942585.1

      Status: VALIDATED

      Source sequence(s)
      AC155720, AC156951
      Consensus CDS
      CCDS20480.1
      UniProtKB/Swiss-Prot
      Q6L8S8
      UniProtKB/TrEMBL
      A4QPE8
      Related
      ENSMUSP00000058253.8, ENSMUST00000057283.8
      Conserved Domains (2) summary
      pfam07691
      Location:143 → 277
      PA14; PA14 domain
      cl11394
      Location:776 → 972
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      120177714..120271879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506316.5 → XP_006506379.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RMF7, A4QPE8
      Related
      ENSMUSP00000148759.2, ENSMUST00000212457.2
      Conserved Domains (2) summary
      smart00758
      Location:140 → 277
      PA14; domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins
      cl11394
      Location:654 → 971
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_017321658.1 → XP_017177147.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X3

      UniProtKB/TrEMBL
      A4QPE8
      Conserved Domains (1) summary
      cl11394
      Location:365 → 682
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. XM_011241395.2 → XP_011239697.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X2

      UniProtKB/TrEMBL
      A4QPE8
      Conserved Domains (2) summary
      smart00758
      Location:117 → 254
      PA14; domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins
      cl11394
      Location:632 → 949
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    4. XM_006506318.5 → XP_006506381.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X4

      Conserved Domains (1) summary
      smart00758
      Location:140 → 277
      PA14; domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6L8S8.1 GenPept UniProtKB/Swiss-Prot:Q6L8S8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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