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    Nufip1 nuclear FMR1 interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 27275, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nufip1provided by MGI
    Official Full Name
    nuclear FMR1 interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1351474
    See related
    Ensembl:ENSMUSG00000022009 AllianceGenome:MGI:1351474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nufip
    Summary
    Enables RNA binding activity. Predicted to be involved in box C/D snoRNP assembly and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is active in synapse. Is expressed in early conceptus; inner cell mass; oocyte; and trophectoderm. Orthologous to human NUFIP1 (nuclear FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.7), adrenal adult (RPKM 3.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nufip1 in Genome Data Viewer
    Location:
    14 D3; 14 40.35 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76348337..76372527)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (76110891..76137379)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36477 Neighboring gene STARR-seq mESC enhancer starr_37162 Neighboring gene STARR-seq mESC enhancer starr_37163 Neighboring gene GPALPP motifs containing 1 Neighboring gene STARR-seq mESC enhancer starr_37165 Neighboring gene STARR-seq mESC enhancer starr_37169 Neighboring gene nuclear encoded tRNA glutamic acid 6 (anticodon TTC) Neighboring gene predicted gene, 36534 Neighboring gene predicted gene, 41214

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in box C/D snoRNP assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in box C/D snoRNP assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perichromatin fibrils ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perichromatin fibrils ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of pre-snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of pre-snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription elongation factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    FMR1-interacting protein NUFIP1
    Names
    nuclear FMRP-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424636.1NP_001411565.1  FMR1-interacting protein NUFIP1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125128
    2. NM_013745.6NP_038773.1  FMR1-interacting protein NUFIP1 isoform 1

      See identical proteins and their annotated locations for NP_038773.1

      Status: VALIDATED

      Source sequence(s)
      AC125128
      Consensus CDS
      CCDS27284.1
      UniProtKB/Swiss-Prot
      Q9CV69, Q9QXX8
      Related
      ENSMUSP00000022586.2, ENSMUST00000022586.2
      Conserved Domains (1) summary
      pfam10453
      Location:207259
      NUFIP1; Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)

    RNA

    1. NR_188811.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125128
    2. NR_188812.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125128
    3. NR_188813.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125128
    4. NR_188814.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125128

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      76348337..76372527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)