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    PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [ Homo sapiens (human) ]

    Gene ID: 9061, updated on 3-Dec-2024

    Summary

    Official Symbol
    PAPSS1provided by HGNC
    Official Full Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by HGNC
    Primary source
    HGNC:HGNC:8603
    See related
    Ensembl:ENSG00000138801 MIM:603262; AllianceGenome:HGNC:8603
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SK1; PAPSS; ATPSK1
    Summary
    Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 32.6), brain (RPKM 30.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PAPSS1 in Genome Data Viewer
    Location:
    4q25
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (107613666..107720234, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (110915973..111022538, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (108534822..108641390, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 551, pseudogene Neighboring gene uncharacterized LOC105377358 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:108626049-108626213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21790 Neighboring gene NANOG hESC enhancer GRCh37_chr4:108655227-108655757 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:108748306-108749505 Neighboring gene sphingomyelin synthase 2 Neighboring gene CYP2U1 and SGMS2 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 733, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:108812473-108813203 Neighboring gene uncharacterized LOC107986298 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:108827506-108828091 Neighboring gene uncharacterized LOC124900751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:108852075-108852582 Neighboring gene cytochrome P450 family 2 subfamily U member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenylylsulfate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenylylsulfate kinase activity TAS
    Traceable Author Statement
    more info
     
    enables nucleotidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sulfate adenylyltransferase (ATP) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfate adenylyltransferase (ATP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sulfate adenylyltransferase (ATP) activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
    Names
    3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1
    PAPS synthase 1
    PAPSS 1
    SK 1
    adenylyl-sulfate kinase
    sulfate adenylyltransferase
    sulfurylase kinase 1
    NP_005434.4
    XP_011530702.1
    XP_011530703.1
    XP_054207171.1
    XP_054207172.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005443.5NP_005434.4  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

      See identical proteins and their annotated locations for NP_005434.4

      Status: VALIDATED

      Source sequence(s)
      AU132232, BC011392, BQ437924
      Consensus CDS
      CCDS3676.1
      UniProtKB/Swiss-Prot
      O43252, O43841, O75332, Q6IAX6, Q96FB1, Q96TF4, Q9P1P9, Q9UE98
      UniProtKB/TrEMBL
      Q05BW9
      Related
      ENSP00000265174.4, ENST00000265174.5
      Conserved Domains (2) summary
      cd00517
      Location:254617
      ATPS; ATP-sulfurylase
      pfam01583
      Location:51205
      APS_kinase; Adenylylsulphate kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      107613666..107720234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532401.2XP_011530703.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

      See identical proteins and their annotated locations for XP_011530703.1

      UniProtKB/TrEMBL
      Q05BW9
      Conserved Domains (2) summary
      cd00517
      Location:233596
      ATPS; ATP-sulfurylase
      pfam01583
      Location:30184
      APS_kinase; Adenylylsulphate kinase
    2. XM_011532400.3XP_011530702.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

      See identical proteins and their annotated locations for XP_011530702.1

      UniProtKB/TrEMBL
      Q05BW9
      Conserved Domains (2) summary
      cd00517
      Location:233596
      ATPS; ATP-sulfurylase
      pfam01583
      Location:30184
      APS_kinase; Adenylylsulphate kinase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      110915973..111022538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351197.1XP_054207172.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

      UniProtKB/TrEMBL
      Q05BW9
    2. XM_054351196.1XP_054207171.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1

      UniProtKB/TrEMBL
      Q05BW9