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    RPS9 ribosomal protein S9 [ Homo sapiens (human) ]

    Gene ID: 6203, updated on 3-Dec-2024

    Summary

    Official Symbol
    RPS9provided by HGNC
    Official Full Name
    ribosomal protein S9provided by HGNC
    Primary source
    HGNC:HGNC:10442
    See related
    Ensembl:ENSG00000170889 MIM:603631; AllianceGenome:HGNC:10442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S9; uS4
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 603.9), bone marrow (RPKM 379.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPS9 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54200858..54207647)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57281246..57288035)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54704726..54711515)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane channel like 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54676977-54677793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54677794-54678609 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54683683-54684198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54684199-54684714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54684715-54685229 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54687509-54688008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54692762-54693444 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54693445-54694126 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54695049-54695250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54696095-54696610 Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54704113-54704783 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54709694-54710202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54710710-54711217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54711218-54711724 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54711820-54712003 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54712450-54712625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54720754-54721590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54721591-54722426 Neighboring gene uncharacterized LOC124904768 Neighboring gene leukocyte immunoglobulin like receptor B3 Neighboring gene uncharacterized LOC107985279 Neighboring gene LSM14A, SCD6 homolog A (S. cerevisiae) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    small ribosomal subunit protein uS4
    Names
    40S ribosomal protein S9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013.4NP_001004.2  small ribosomal subunit protein uS4 isoform a

      See identical proteins and their annotated locations for NP_001004.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 3, and 4, encodes isoform a.
      Source sequence(s)
      AB055775, BC007410, U14971
      Consensus CDS
      CCDS12884.1
      UniProtKB/Swiss-Prot
      A9C4C1, P46781, Q4QRK7, Q9BVZ0
      Related
      ENSP00000302896.4, ENST00000302907.9
      Conserved Domains (1) summary
      PTZ00155
      Location:11177
      PTZ00155; 40S ribosomal protein S9; Provisional
    2. NM_001321701.2NP_001308630.1  small ribosomal subunit protein uS4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1, 3, and 4, encodes isoform a.
      Source sequence(s)
      BC050660, CD389050
      Consensus CDS
      CCDS12884.1
      UniProtKB/Swiss-Prot
      A9C4C1, P46781, Q4QRK7, Q9BVZ0
      Conserved Domains (1) summary
      PTZ00155
      Location:11177
      PTZ00155; 40S ribosomal protein S9; Provisional
    3. NM_001321702.2NP_001308631.1  small ribosomal subunit protein uS4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 1, 2, and 4, encodes isoform a.
      Source sequence(s)
      AC245052, BC050660, BM313608, CD389050
      Consensus CDS
      CCDS12884.1
      UniProtKB/Swiss-Prot
      A9C4C1, P46781, Q4QRK7, Q9BVZ0
      Related
      ENSP00000375632.1, ENST00000391752.5
      Conserved Domains (1) summary
      PTZ00155
      Location:11177
      PTZ00155; 40S ribosomal protein S9; Provisional
    4. NM_001321704.2NP_001308633.1  small ribosomal subunit protein uS4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 2, and 3, encodes isoform a.
      Source sequence(s)
      BC050660, BQ069656, CD389050
      Consensus CDS
      CCDS12884.1
      UniProtKB/Swiss-Prot
      A9C4C1, P46781, Q4QRK7, Q9BVZ0
      Conserved Domains (1) summary
      PTZ00155
      Location:11177
      PTZ00155; 40S ribosomal protein S9; Provisional
    5. NM_001321705.2NP_001308634.1  small ribosomal subunit protein uS4 isoform b

      Status: REVIEWED

      Source sequence(s)
      AW163829, BC050660, CD389050
      Conserved Domains (1) summary
      PTZ00155
      Location:11136
      PTZ00155; 40S ribosomal protein S9; Provisional
    6. NM_001321706.2NP_001308635.1  small ribosomal subunit protein uS4 isoform c

      Status: REVIEWED

      Source sequence(s)
      BC050660, CD389050
      Consensus CDS
      CCDS82397.1
      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
      Related
      ENSP00000375631.3, ENST00000391751.7
      Conserved Domains (1) summary
      PTZ00155
      Location:1176
      PTZ00155; 40S ribosomal protein S9; Provisional

    RNA

    1. NR_135762.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC050660, BG911482, CD389050
      Related
      ENST00000436445.5
    2. NR_135763.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC050660, BG753945, CD389050

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54200858..54207647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027112.2XP_016882601.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
      Conserved Domains (1) summary
      PTZ00155
      Location:1176
      PTZ00155; 40S ribosomal protein S9; Provisional

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      175657..182446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      175840..182629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330201.1XP_054186176.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
    2. XM_054330200.1XP_054186175.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      175840..182629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330497.1XP_054186472.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      175840..182629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330747.1XP_054186722.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
    2. XM_054330746.1XP_054186721.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      175840..182629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330978.1XP_054186953.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
    2. XM_054330977.1XP_054186952.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      175840..182629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331261.1XP_054187236.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
    2. XM_054331260.1XP_054187235.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      175830..182618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331530.1XP_054187505.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0

    Reference GRCh38.p14 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

      Range
      175840..182629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333575.1XP_054189550.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
    2. XM_054333574.1XP_054189549.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      175840..182629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333677.1XP_054189652.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
    2. XM_054333676.1XP_054189651.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57281246..57288035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321702.1XP_054177677.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0
    2. XM_054321701.1XP_054177676.1  small ribosomal subunit protein uS4 isoform X1

      UniProtKB/TrEMBL
      A8MXK4, F2Z3C0