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    RNASE11 ribonuclease A family member 11 (inactive) [ Homo sapiens (human) ]

    Gene ID: 122651, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RNASE11provided by HGNC
    Official Full Name
    ribonuclease A family member 11 (inactive)provided by HGNC
    Primary source
    HGNC:HGNC:19269
    See related
    Ensembl:ENSG00000173464 AllianceGenome:HGNC:19269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAJ1; C14orf6; HEL-S-84p
    Summary
    Predicted to enable endonuclease activity and nucleic acid binding activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 14.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See RNASE11 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20582892..20590257, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14780017..14787383, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21051051..21058416, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:20998995-20999494 Neighboring gene SET pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:21027647-21028226 Neighboring gene ribonuclease A family member 9 (inactive) Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21046340-21047110 Neighboring gene RNASE11 and RNASE12 antisense RNA 1 Neighboring gene ribonuclease A family member 12 (inactive) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5567 Neighboring gene uncharacterized LOC124903280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5568 Neighboring gene tRNA-Pro (anticodon AGG) 2-5 Neighboring gene tRNA-Leu (anticodon AAG) 2-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Cho S, et al. Genomics, 2005 Feb. PMID 15676279
    2. Comparative genomic analysis of eutherian ribonuclease A genes. Premzl M. Mol Genet Genomics, 2014 Apr. PMID 24337645
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables RNA nuclease activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable ribonuclease 11
    Names
    epididymis secretory sperm binding protein Li 84p
    ribonuclease 11
    ribonuclease A J1
    ribonuclease, RNase A family, 11 (non-active)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394189.1 → NP_001381118.1  probable ribonuclease 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    2. NM_001394190.1 → NP_001381119.1  probable ribonuclease 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Related
      ENSP00000452412.2, ENST00000557105.7
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    3. NM_001394191.1 → NP_001381120.1  probable ribonuclease 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Related
      ENSP00000401398.2, ENST00000443456.6
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    4. NM_001394192.1 → NP_001381121.1  probable ribonuclease 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Related
      ENSP00000451563.1, ENST00000555841.5
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    5. NM_001394193.1 → NP_001381122.1  probable ribonuclease 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Related
      ENSP00000395210.2, ENST00000432835.6
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    6. NM_001394194.1 → NP_001381123.1  probable ribonuclease 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Related
      ENSP00000381093.2, ENST00000398009.6
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    7. NM_001394195.1 → NP_001381124.1  probable ribonuclease 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Related
      ENSP00000381092.2, ENST00000398008.6
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    8. NM_001394196.1 → NP_001381125.1  probable ribonuclease 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Related
      ENSP00000451318.1, ENST00000553849.1
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    9. NM_145250.5 → NP_660293.1  probable ribonuclease 11 precursor

      See identical proteins and their annotated locations for NP_660293.1

      Status: VALIDATED

      Source sequence(s)
      AL163195
      Consensus CDS
      CCDS9553.1
      UniProtKB/Swiss-Prot
      Q8TAA1
      UniProtKB/TrEMBL
      C9JYR4, Q5GAN5
      Conserved Domains (1) summary
      cd00163
      Location:73 → 187
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      20582892..20590257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      14780017..14787383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TAA1.1 GenPept UniProtKB/Swiss-Prot:Q8TAA1

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