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    CAPZA1 capping actin protein of muscle Z-line subunit alpha 1 [ Homo sapiens (human) ]

    Gene ID: 829, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CAPZA1provided by HGNC
    Official Full Name
    capping actin protein of muscle Z-line subunit alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:1488
    See related
    Ensembl:ENSG00000116489 MIM:601580; AllianceGenome:HGNC:1488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPZ; CAZ1; CAPPA1
    Summary
    CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 69.5), appendix (RPKM 61.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CAPZA1 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112619832..112671616)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112632399..112684197)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113162454..113214238)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1513 Neighboring gene MPRA-validated peak369 silencer Neighboring gene microRNA 4256 Neighboring gene Wnt family member 2B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113050855-113051398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1200 Neighboring gene Sharpr-MPRA regulatory region 8072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113052323-113052822 Neighboring gene suppression of tumorigenicity 7 like Neighboring gene MPRA-validated peak370 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:113161935-113163134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113180612-113181112 Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113234976-113235476 Neighboring gene Mov10 RNA helicase Neighboring gene Sharpr-MPRA regulatory region 4682 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113242906-113243833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113246858-113247412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1203 Neighboring gene ras homolog family member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prognostic value of CAPZA1 overexpression in gastric cancer. Lee YJ, et al. Int J Oncol, 2013 May. PMID 23545944, Free PMC Article
    2. CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy. Tsugawa H, et al. Autophagy, 2019 Feb. PMID 30176157, Free PMC Article
    3. CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma. Huang D, et al. J Exp Clin Cancer Res, 2017 Jan 16. PMID 28093067, Free PMC Article
    4. A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. McClintock KA, et al. J Biol Chem, 2003 Feb 21. PMID 12480931
    5. Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed end. Bombardier JP, et al. Nat Commun, 2015 Nov 13. PMID 26566078, Free PMC Article

    See all (216) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
      Title: Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.
    2. Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
      Title: Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
    3. A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks.
      Title: A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks.
    4. in CAPZA1-overexpressing gastric epithelial cells infected with H. pylori, autolysosome formation is inhibited and CagA escapes autophagic degradation.
      Title: CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy.
    5. Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells.
      Title: CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma.
    6. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2.
      Title: Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.
    7. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return.
      Title: Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed end.
    8. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion.
      Title: Prognostic value of CAPZA1 overexpression in gastric cancer.
    9. CAPAZA1 is over expressed in malignant melanoma.
      Title: Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.
    10. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management.
      Title: Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of capping protein (actin filament) muscle Z-line, alpha 1 (CAPZA1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cortical cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    F-actin-capping protein subunit alpha-1
    Names
    Cap Z
    capZ alpha-1
    capping actin protein of muscle Z-line alpha subunit 1
    capping protein (actin filament) muscle Z-line, alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006135.3 → NP_006126.1  F-actin-capping protein subunit alpha-1

      See identical proteins and their annotated locations for NP_006126.1

      Status: REVIEWED

      Source sequence(s)
      BC000144
      Consensus CDS
      CCDS30805.1
      UniProtKB/Swiss-Prot
      P52907, Q53FQ6, Q6FHD5
      UniProtKB/TrEMBL
      A8K0T9
      Related
      ENSP00000263168.3, ENST00000263168.4
      Conserved Domains (1) summary
      pfam01267
      Location:14 → 282
      F-actin_cap_A; F-actin capping protein alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      112619832..112671616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002424.3 → XP_016857913.1  F-actin-capping protein subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A8K0T9

    2. XM_011542225.4 → XP_011540527.1  F-actin-capping protein subunit alpha-1 isoform X2

      Related
      ENST00000498626.1
      Conserved Domains (1) summary
      pfam01267
      Location:14 → 195
      F-actin_cap_A; F-actin capping protein alpha subunit

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      112632399..112684197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338936.1 → XP_054194911.1  F-actin-capping protein subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A8K0T9

    2. XM_054338937.1 → XP_054194912.1  F-actin-capping protein subunit alpha-1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52907.3 GenPept UniProtKB/Swiss-Prot:P52907

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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