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    PRR11 proline rich 11 [ Homo sapiens (human) ]

    Gene ID: 55771, updated on 10-Dec-2024

    Summary

    Official Symbol
    PRR11provided by HGNC
    Official Full Name
    proline rich 11provided by HGNC
    Primary source
    HGNC:HGNC:25619
    See related
    Ensembl:ENSG00000068489 MIM:615920; AllianceGenome:HGNC:25619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in regulation of cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 3.3), lymph node (RPKM 2.7) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PRR11 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (59155746..59206709)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (60023844..60074810)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57233107..57284070)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8777 Neighboring gene microRNA 454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12502 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:57235593-57236792 Neighboring gene microRNA 301a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12503 Neighboring gene speedy/RINGO cell cycle regulator family member E22, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:57259739-57260240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:57297898-57298448 Neighboring gene SMG8 nonsense mediated mRNA decay factor Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • FLJ11029

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in membrane PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    proline-rich protein 11
    Names
    transcription repressor of MHCII

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018304.4NP_060774.2  proline-rich protein 11

      See identical proteins and their annotated locations for NP_060774.2

      Status: VALIDATED

      Source sequence(s)
      AC099850, AK225377, AW957315, DB106349
      Consensus CDS
      CCDS11614.1
      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4
      Related
      ENSP00000262293.5, ENST00000262293.9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      59155746..59206709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450828.2XP_024306596.1  proline-rich protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4
    2. XM_047436387.1XP_047292343.1  proline-rich protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      60023844..60074810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316639.1XP_054172614.1  proline-rich protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4
    2. XM_054316640.1XP_054172615.1  proline-rich protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q96HE9, Q9NUZ7, Q9NXE9
      UniProtKB/TrEMBL
      D2SNZ4
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