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    KCNH6 potassium voltage-gated channel subfamily H member 6 [ Homo sapiens (human) ]

    Gene ID: 81033, updated on 27-Nov-2024

    Summary

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    Official Symbol
    KCNH6provided by HGNC
    Official Full Name
    potassium voltage-gated channel subfamily H member 6provided by HGNC
    Primary source
    HGNC:HGNC:18862
    See related
    Ensembl:ENSG00000173826 MIM:608168; AllianceGenome:HGNC:18862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERG2; ERG-2; HERG2; Kv11.2; hERG-2
    Summary
    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in kidney (RPKM 3.1), small intestine (RPKM 1.8) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KCNH6 in Genome Data Viewer
    Location:
    17q23.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (63523358..63548992)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (64393673..64419606)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61600719..61626353)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61563854-61564354 Neighboring gene angiotensin I converting enzyme Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12546 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:61594037-61595236 Neighboring gene angiotensin I converting enzyme 3, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61611272-61611775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:61626768-61627752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8820 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:61640093-61640313 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene RNA, U6 small nuclear 288, pseudogene Neighboring gene translational activator of cytochrome c oxidase I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition. Zhang YC, et al. Oxid Med Cell Longev, 2022. PMID 36217412, Free PMC Article
    2. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Zhao MM, et al. Nat Commun, 2021 Sep 23. PMID 34556670, Free PMC Article
    3. Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study. Yamoah K, et al. Prostate, 2021 Dec. PMID 34529278, Free PMC Article
    4. From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. Yang JK, et al. Cell Rep, 2018 Dec 26. PMID 30590050
    5. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma. Wang M, et al. Biochem Biophys Res Commun, 2015 May 1. PMID 25783051

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
      Title: KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
    2. Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.
      Title: Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.
    3. Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study.
      Title: Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study.
    4. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
      Title: Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
    5. dysfunction of KCNH6 causes overstimulation of insulin secretion in the short term and beta cell failure in the long term.
      Title: From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion.
    6. results indicated that downregulation of miR-224 suppressed cell growth and resulted in the enhancement of cell apoptosis through activation of the ERG2-BAK-induced apoptosis pathway
      Title: MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma.
    7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    8. Transcripts for HERG1 were present in all adenomas and although transcripts for HERG2 and HERG3 were also detected, their expression level was more variable.
      Title: HERG K(+) currents in human prolactin-secreting adenoma cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane repolarization during cardiac muscle cell action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated inwardly rectifying potassium channel KCNH6; potassium voltage-gated channel subfamily H member 6
    Names
    eag-related gene member 2
    ether-a-go-go-related protein 2
    potassium channel, voltage gated eag related subfamily H, member 6
    potassium voltage-gated channel, subfamily H (eag-related), member 6
    voltage-gated potassium channel subunit Kv11.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278919.2 → NP_001265848.1  voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3

      See identical proteins and their annotated locations for NP_001265848.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter, compared to isoform 1.
      Source sequence(s)
      AA825356, AK090969, AK296498, BE465143, BM561167, CD632730, DB147394, DB506421
      Consensus CDS
      CCDS62290.1
      UniProtKB/Swiss-Prot
      J9JID4, Q9BRD7, Q9H252
      UniProtKB/TrEMBL
      B4DKC0
      Related
      ENSP00000318212.5, ENST00000314672.10
      Conserved Domains (6) summary
      COG0664
      Location:588 → 704
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    2. NM_001278920.2 → NP_001265849.1  voltage-gated inwardly rectifying potassium channel KCNH6 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, uses a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AA825356, AK090969, AK298363, BE465143, CD632730, DB506421
      UniProtKB/TrEMBL
      B4DPJ3
      Conserved Domains (4) summary
      COG0664
      Location:465 → 581
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:471 → 582
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:173 → 397
      Ion_trans; Ion transport protein
      pfam07885
      Location:340 → 394
      Ion_trans_2; Ion channel

    3. NM_030779.4 → NP_110406.1  voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1

      See identical proteins and their annotated locations for NP_110406.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA825356, AF311913, BE465143, CD632730, DB147394, DB506421
      Consensus CDS
      CCDS11638.1
      UniProtKB/TrEMBL
      B4DKC0
      Related
      ENSP00000463533.1, ENST00000583023.1
      Conserved Domains (6) summary
      COG0664
      Location:588 → 704
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    4. NM_173092.4 → NP_775115.1  voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2

      See identical proteins and their annotated locations for NP_775115.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment and an alternate in-frame exon but includes an alternate 3' terminal exon with an alternate 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter, compared to isoform 1.
      Source sequence(s)
      AC113554, AK091877, CD632730
      Consensus CDS
      CCDS11639.1
      UniProtKB/TrEMBL
      B4DKC0
      Related
      ENSP00000463830.1, ENST00000581784.5
      Conserved Domains (6) summary
      COG0664
      Location:535 → 651
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:541 → 652
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 467
      Ion_trans; Ion transport protein
      pfam07885
      Location:393 → 464
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      63523358..63548992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025175.2 → XP_016880664.1  potassium voltage-gated channel subfamily H member 6 isoform X1

      UniProtKB/TrEMBL
      B4DKC0
      Conserved Domains (6) summary
      COG0664
      Location:588 → 704
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    2. XM_017025177.2 → XP_016880666.1  potassium voltage-gated channel subfamily H member 6 isoform X3

      UniProtKB/Swiss-Prot
      J9JID4, Q9BRD7, Q9H252
      UniProtKB/TrEMBL
      B4DKC0
      Conserved Domains (6) summary
      COG0664
      Location:588 → 704
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    3. XM_047436856.1 → XP_047292812.1  potassium voltage-gated channel subfamily H member 6 isoform X11

    4. XM_017025176.3 → XP_016880665.1  potassium voltage-gated channel subfamily H member 6 isoform X2

      UniProtKB/TrEMBL
      B4DKC0

    5. XM_017025178.3 → XP_016880667.1  potassium voltage-gated channel subfamily H member 6 isoform X4

      UniProtKB/TrEMBL
      B4DKC0

    6. XM_017025179.3 → XP_016880668.1  potassium voltage-gated channel subfamily H member 6 isoform X5

      UniProtKB/TrEMBL
      B4DKC0

    7. XM_011525310.3 → XP_011523612.1  potassium voltage-gated channel subfamily H member 6 isoform X9

      See identical proteins and their annotated locations for XP_011523612.1

      UniProtKB/TrEMBL
      B4DKC0
      Related
      ENSP00000396900.2, ENST00000456941.6
      Conserved Domains (6) summary
      COG0664
      Location:535 → 651
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:541 → 652
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 467
      Ion_trans; Ion transport protein
      pfam07885
      Location:393 → 464
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    8. XM_047436854.1 → XP_047292810.1  potassium voltage-gated channel subfamily H member 6 isoform X6

    9. XM_047436855.1 → XP_047292811.1  potassium voltage-gated channel subfamily H member 6 isoform X10

    10. XM_017025180.3 → XP_016880669.1  potassium voltage-gated channel subfamily H member 6 isoform X12

      UniProtKB/TrEMBL
      B4DPJ3

    11. XM_011525309.3 → XP_011523611.1  potassium voltage-gated channel subfamily H member 6 isoform X8

      UniProtKB/TrEMBL
      B4DKC0
      Conserved Domains (6) summary
      COG0664
      Location:588 → 704
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    12. XM_011525308.3 → XP_011523610.1  potassium voltage-gated channel subfamily H member 6 isoform X7

      UniProtKB/TrEMBL
      B4DKC0
      Conserved Domains (6) summary
      COG0664
      Location:588 → 704
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    13. XM_011525311.2 → XP_011523613.1  potassium voltage-gated channel subfamily H member 6 isoform X13

      Conserved Domains (6) summary
      COG0664
      Location:588 → 724
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    14. XM_011525312.2 → XP_011523614.1  potassium voltage-gated channel subfamily H member 6 isoform X14

      Conserved Domains (6) summary
      COG0664
      Location:588 → 704
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    15. XM_011525313.2 → XP_011523615.1  potassium voltage-gated channel subfamily H member 6 isoform X15

      Conserved Domains (6) summary
      COG0664
      Location:588 → 704
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594 → 705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41 → 132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296 → 520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463 → 517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 132
      PAS_9; PAS domain

    RNA

    1. XR_934568.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      64393673..64419606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317425.1 → XP_054173400.1  potassium voltage-gated channel subfamily H member 6 isoform X1

    2. XM_054317427.1 → XP_054173402.1  potassium voltage-gated channel subfamily H member 6 isoform X3

    3. XM_054317426.1 → XP_054173401.1  potassium voltage-gated channel subfamily H member 6 isoform X2

    4. XM_054317428.1 → XP_054173403.1  potassium voltage-gated channel subfamily H member 6 isoform X4

    5. XM_054317429.1 → XP_054173404.1  potassium voltage-gated channel subfamily H member 6 isoform X5

    6. XM_054317433.1 → XP_054173408.1  potassium voltage-gated channel subfamily H member 6 isoform X9

    7. XM_054317430.1 → XP_054173405.1  potassium voltage-gated channel subfamily H member 6 isoform X6

    8. XM_054317434.1 → XP_054173409.1  potassium voltage-gated channel subfamily H member 6 isoform X10

    9. XM_054317436.1 → XP_054173411.1  potassium voltage-gated channel subfamily H member 6 isoform X12

    10. XM_054317435.1 → XP_054173410.1  potassium voltage-gated channel subfamily H member 6 isoform X11

    11. XM_054317432.1 → XP_054173407.1  potassium voltage-gated channel subfamily H member 6 isoform X8

    12. XM_054317431.1 → XP_054173406.1  potassium voltage-gated channel subfamily H member 6 isoform X7

    13. XM_054317437.1 → XP_054173412.1  potassium voltage-gated channel subfamily H member 6 isoform X13

    14. XM_054317438.1 → XP_054173413.1  potassium voltage-gated channel subfamily H member 6 isoform X14

    15. XM_054317439.1 → XP_054173414.1  potassium voltage-gated channel subfamily H member 6 isoform X15

    RNA

    1. XR_008484947.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H252.2 GenPept UniProtKB/Swiss-Prot:Q9H252

    Gene LinkOut

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