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    MYEOV myeloma overexpressed [ Homo sapiens (human) ]

    Gene ID: 26579, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MYEOVprovided by HGNC
    Official Full Name
    myeloma overexpressedprovided by HGNC
    Primary source
    HGNC:HGNC:7563
    See related
    Ensembl:ENSG00000172927 MIM:605625; AllianceGenome:HGNC:7563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OCIM
    Expression
    Biased expression in stomach (RPKM 11.5), esophagus (RPKM 10.9) and 5 other tissues See more
    Orthologs
    all
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    Genomic context

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    See MYEOV in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69294155..69297287)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69311284..69314452)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69061622..69064754)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369367 Neighboring gene uncharacterized LOC105369368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5154 Neighboring gene VISTA enhancer hs2073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69060193-69060744 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:69064594-69065793 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69066990-69067178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69078345-69078844 Neighboring gene interferon induced transmembrane protein 9 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69088091-69088958 Neighboring gene uncharacterized LOC105369370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69153613-69154114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69154115-69154614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69157262-69158194 Neighboring gene MPRA-validated peak1324 silencer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MYEOV with High Frequencies of Mutations in Head and Neck Cancers Facilitates Cancer Cell Malignant Behaviors. Ou D, et al. Biochem Genet, 2024 Jun. PMID 37667096
    2. Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). Janssen JW, et al. Blood, 2000 Apr 15. PMID 10753852
    3. MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas. Janssen JW, et al. J Hum Genet, 2002. PMID 12202983
    4. Control of MYEOV protein synthesis by upstream open reading frames. de Almeida RA, et al. J Biol Chem, 2006 Jan 13. PMID 16275643
    5. MYEOV (myeloma overexpressed gene) drives colon cancer cell migration and is regulated by PGE2. Lawlor G, et al. J Exp Clin Cancer Res, 2010 Jun 22. PMID 20569498, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYEOV with High Frequencies of Mutations in Head and Neck Cancers Facilitates Cancer Cell Malignant Behaviors.
      Title: MYEOV with High Frequencies of Mutations in Head and Neck Cancers Facilitates Cancer Cell Malignant Behaviors.
    2. Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma.
      Title: Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma.
    3. MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway.
      Title: MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway.
    4. The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma.
      Title: The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma.
    5. Overexpression of MYEOV predicting poor prognosis in patients with pancreatic ductal adenocarcinoma.
      Title: Overexpression of MYEOV predicting poor prognosis in patients with pancreatic ductal adenocarcinoma.
    6. High expression of MYEOV reflects poor prognosis in non-small cell lung cancer.
      Title: High expression of MYEOV reflects poor prognosis in non-small cell lung cancer.
    7. MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity.
      Title: MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity.
    8. experiments demonstrated that the MYEOV ceRNA sequestered miR-30c-2-3p from binding its targets TGFBR2 and USP15 mRNAs, which in turn leading to constitutive activation of TGF-beta signaling and tumor progression in Non-small cell lung cancer.
      Title: MYEOV functions as an amplified competing endogenous RNA in promoting metastasis by activating TGF-β pathway in NSCLC.
    9. The results of these studies provide supporting evidence for MYEOV and NEGR1 as gene targets of 11q13 gains and 1p31 deletions in a neuroblastoma subset.
      Title: Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma.
    10. MYEOV expression is a prognostic factor for patients with multiple myeloma, in part through a role of MYEOV in the control of MMC proliferation.
      Title: MYEOV is a prognostic factor in multiple myeloma.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association scan for variants associated with early-onset prostate cancer.
    EBI GWAS Catalog
    Genome-wide association study identifies five new breast cancer susceptibility loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myeloma-overexpressed gene protein
    Names
    myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
    myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)
    oncogene in multiple myeloma

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293291.2 → NP_001280220.1  myeloma-overexpressed gene protein isoform 1

      See identical proteins and their annotated locations for NP_001280220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      AK026148, AK290121, BC011815, CB147813
      Consensus CDS
      CCDS8190.1
      UniProtKB/Swiss-Prot
      Q96EZ4, Q9UGN6, Q9UGN7
      UniProtKB/TrEMBL
      A8K256
      Related
      ENSP00000412482.2, ENST00000441339.3

    2. NM_001293294.2 → NP_001280223.1  myeloma-overexpressed gene protein isoform 2

      See identical proteins and their annotated locations for NP_001280223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal splice junction, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
      Source sequence(s)
      AJ223366, AK290121, BC011815, CB147813
      Consensus CDS
      CCDS73340.1
      UniProtKB/TrEMBL
      A8K256, F5H0B3
      Related
      ENST00000535653.1

    3. NM_001293296.2 → NP_001280225.1  myeloma-overexpressed gene protein isoform 2

      See identical proteins and their annotated locations for NP_001280225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate splice site in the 5' UTR, which results in translation initiation at a downstream AUG start codon, and it also lacks an internal splice junction, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
      Source sequence(s)
      AK026148, AK290121, BC011815, CB147813
      Consensus CDS
      CCDS73340.1
      UniProtKB/TrEMBL
      A8K256, F5H0B3
      Related
      ENSP00000438100.1, ENST00000535407.1

    4. NM_001300923.2 → NP_001287852.1  myeloma-overexpressed gene protein isoform 2

      See identical proteins and their annotated locations for NP_001287852.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
      Source sequence(s)
      AK026148, AK290121, BC011815, CB147813, DA377031
      Consensus CDS
      CCDS73340.1
      UniProtKB/TrEMBL
      A8K256, F5H0B3

    5. NM_001300924.2 → NP_001287853.1  myeloma-overexpressed gene protein isoform 2

      See identical proteins and their annotated locations for NP_001287853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 3, 4, 5, and 6 all encode the same isoform (2).
      Source sequence(s)
      AK026148, AK290121, BC011815, CB147813, DA902417
      Consensus CDS
      CCDS73340.1
      UniProtKB/TrEMBL
      A8K256, F5H0B3

    6. NM_138768.4 → NP_620123.2  myeloma-overexpressed gene protein isoform 1

      See identical proteins and their annotated locations for NP_620123.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, and encodes the same isoform 1, compared to variant 1.
      Source sequence(s)
      AJ223366, AK290121, BC011815, CB147813
      Consensus CDS
      CCDS8190.1
      UniProtKB/Swiss-Prot
      Q96EZ4, Q9UGN6, Q9UGN7
      UniProtKB/TrEMBL
      A8K256
      Related
      ENSP00000308330.3, ENST00000308946.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      69294155..69297287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426763.1 → XP_047282719.1  myeloma-overexpressed gene protein isoform X1

      UniProtKB/Swiss-Prot
      Q96EZ4, Q9UGN6, Q9UGN7
      UniProtKB/TrEMBL
      A8K256

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      69311284..69314452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368411.1 → XP_054224386.1  myeloma-overexpressed gene protein isoform X1

      UniProtKB/Swiss-Prot
      Q96EZ4, Q9UGN6, Q9UGN7
      UniProtKB/TrEMBL
      A8K256
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96EZ4.2 GenPept UniProtKB/Swiss-Prot:Q96EZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools