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    RPL32 ribosomal protein L32 [ Homo sapiens (human) ]

    Gene ID: 6161, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RPL32provided by HGNC
    Official Full Name
    ribosomal protein L32provided by HGNC
    Primary source
    HGNC:HGNC:10336
    See related
    Ensembl:ENSG00000144713 AllianceGenome:HGNC:10336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L32; eL32; PP9932
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 460.1), bone marrow (RPKM 265.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPL32 in Genome Data Viewer
    Location:
    3p25.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (12834485..12841582, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (12835994..12843091, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12875984..12883081, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12779747-12780569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14067 Neighboring gene transmembrane protein 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19453 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12800761-12801346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14069 Neighboring gene keratin 18 pseudogene 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12845071-12845571 Neighboring gene cullin associated and neddylation dissociated 2 (putative) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14070 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:12855381-12855561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12871622-12872570 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12881424-12882362 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12882363-12883299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19454 Neighboring gene small nucleolar RNA, H/ACA box 7A Neighboring gene uncharacterized LOC124909346 Neighboring gene microtubule affinity regulating kinase 4 pseudogene Neighboring gene microtubule affinity regulating kinase 3 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Biological effect of ribosomal protein L32 on human breast cancer cell behavior. Xu L, et al. Mol Med Rep, 2020 Sep. PMID 32705264, Free PMC Article
    2. Assignment of the L32 ribosomal protein gene (RPL32) to human chromosome 3q13.3-->q21 by in situ hybridization. Vorobieva NV, et al. Cytogenet Cell Genet, 1997. PMID 9284913
    3. Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters. Baumbusch LO, et al. Mol Cancer, 2006 Oct 20. PMID 17054774, Free PMC Article
    4. An abnormality in glucocorticoid receptor expression differentiates steroid responders from nonresponders in keloid disease. Rutkowski D, et al. Br J Dermatol, 2015 Sep. PMID 25712143, Free PMC Article
    5. A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. Young JA, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3866218, Free PMC Article

    See all (168) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biological effect of ribosomal protein L32 on human breast cancer cell behavior.
      Title: Biological effect of ribosomal protein L32 on human breast cancer cell behavior.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, ribosomal protein L32 (RPL32), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL32
    Names
    60S ribosomal protein L32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000994.4 → NP_000985.1  large ribosomal subunit protein eL32

      See identical proteins and their annotated locations for NP_000985.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC034198, CA436299, CF124158
      Consensus CDS
      CCDS2614.1
      UniProtKB/Swiss-Prot
      B2R4Q3, P02433, P62910
      UniProtKB/TrEMBL
      D3YTB1
      Related
      ENSP00000416429.2, ENST00000429711.7
      Conserved Domains (1) summary
      pfam01655
      Location:17 → 124
      Ribosomal_L32e; Ribosomal protein L32

    2. NM_001007073.1 → NP_001007074.1  large ribosomal subunit protein eL32

      See identical proteins and their annotated locations for NP_001007074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC034198, BQ068496, CA436299, CF124158
      Consensus CDS
      CCDS2614.1
      UniProtKB/Swiss-Prot
      B2R4Q3, P02433, P62910
      UniProtKB/TrEMBL
      D3YTB1
      Related
      ENSP00000380158.1, ENST00000396957.5
      Conserved Domains (1) summary
      pfam01655
      Location:17 → 124
      Ribosomal_L32e; Ribosomal protein L32

    3. NM_001007074.1 → NP_001007075.1  large ribosomal subunit protein eL32

      See identical proteins and their annotated locations for NP_001007075.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a 5' exon but has an alternate segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC034198, BC070209, BF960792, CA436299
      Consensus CDS
      CCDS2614.1
      UniProtKB/Swiss-Prot
      B2R4Q3, P02433, P62910
      UniProtKB/TrEMBL
      D3YTB1
      Related
      ENSP00000380156.2, ENST00000396953.6
      Conserved Domains (1) summary
      pfam01655
      Location:17 → 124
      Ribosomal_L32e; Ribosomal protein L32

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      12834485..12841582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      12835994..12843091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62910.2 GenPept UniProtKB/Swiss-Prot:P62910

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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