U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    HOXD11 homeobox D11 [ Homo sapiens (human) ]

    Gene ID: 3237, updated on 10-Dec-2024

    Summary

    Official Symbol
    HOXD11provided by HGNC
    Official Full Name
    homeobox D11provided by HGNC
    Primary source
    HGNC:HGNC:5134
    See related
    Ensembl:ENSG00000128713 MIM:142986; AllianceGenome:HGNC:5134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX4; HOX4F
    Summary
    This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in endometrium (RPKM 10.2), colon (RPKM 4.5) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HOXD11 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (176107280..176115679)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (176595402..176599952)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (176972008..176974482)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene homeobox D13 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176961670-176962253 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176962254-176962836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176964378-176965110 Neighboring gene homeobox D12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176968878-176969864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176980400-176981072 Neighboring gene homeobox D10 Neighboring gene homeobox D9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in branching involved in ureteric bud morphogenesis  
    involved_in dorsal/ventral pattern formation  
    involved_in embryonic skeletal joint morphogenesis  
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    homeobox protein Hox-D11
    Names
    Hox-4.6, mouse, homolog of
    homeo box 4F
    homeo box D11
    homeobox protein Hox-4F

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021192.3 → NP_067015.2  homeobox protein Hox-D11

      See identical proteins and their annotated locations for NP_067015.2

      Status: REVIEWED

      Source sequence(s)
      AC009336
      Consensus CDS
      CCDS2265.1
      UniProtKB/Swiss-Prot
      A6NIS4, P31277, Q9NS02
      Related
      ENSP00000249504.5, ENST00000249504.7
      Conserved Domains (2) summary
      pfam00046
      Location:269 → 322
      Homeobox; Homeobox domain
      pfam12045
      Location:26 → 185
      DUF3528; Protein of unknown function (DUF3528)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      176107280..176115679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007073114.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      176595402..176599952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486353.1 RNA Sequence

    External link. Please review our privacy policy.