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    PLEKHA7 pleckstrin homology domain containing A7 [ Homo sapiens (human) ]

    Gene ID: 144100, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PLEKHA7provided by HGNC
    Official Full Name
    pleckstrin homology domain containing A7provided by HGNC
    Primary source
    HGNC:HGNC:27049
    See related
    Ensembl:ENSG00000166689 MIM:612686; AllianceGenome:HGNC:27049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables delta-catenin binding activity. Involved in epithelial cell-cell adhesion; pore complex assembly; and zonula adherens maintenance. Located in several cellular components, including centrosome; nucleoplasm; and zonula adherens. Part of pore complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 8.9), duodenum (RPKM 8.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLEKHA7 in Genome Data Viewer
    Location:
    11p15.2-p15.1
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (16777297..17014414, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (16874672..17111588, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (16798844..17035961, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 6 Neighboring gene uncharacterized LOC105376571 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16691079-16691580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16691581-16692082 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16699888-16700416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16700417-16700944 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:16730412-16730912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:16730913-16731413 Neighboring gene MPRA-validated peak1219 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16800297-16801020 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:16801021-16801743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16802139-16802833 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16802834-16803527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16803848-16804825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16812593-16813093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16812092-16812592 Neighboring gene chromosome 11 open reading frame 58 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:16823697-16824896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16836605-16837105 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:16875052-16875264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4481 Neighboring gene VISTA enhancer hs2096 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:16918881-16919566 Neighboring gene RN7SK pseudogene 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16946213-16946824 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:16957385-16957896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4482 Neighboring gene uncharacterized LOC124902817 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17003172-17003810 Neighboring gene small nucleolar RNA, C/D box 147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4483 Neighboring gene Sharpr-MPRA regulatory region 14902 Neighboring gene ribosomal protein L36a pseudogene 37 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:17043091-17043592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17058129-17058705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17058706-17059281 Neighboring gene small nucleolar RNA, C/D box 14A Neighboring gene olfactory receptor family 7 subfamily E member 14 pseudogene Neighboring gene ribosomal protein S13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer. Jeung HC, et al. Exp Cell Res, 2021 Dec 15. PMID 34800542, Free PMC Article
    2. Genetic up-regulation and overexpression of PLEKHA7 differentiates invasive lobular carcinomas from invasive ductal carcinomas. Castellana B, et al. Hum Pathol, 2012 Nov. PMID 22542108
    3. Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids. Aleshin AE, et al. Structure, 2021 Sep 2. PMID 33878292, Free PMC Article
    4. Expression of the primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 in endothelial and epithelial cell junctions in the eye. Lee MC, et al. Invest Ophthalmol Vis Sci, 2014 May 6. PMID 24801512
    5. The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas. Tille JC, et al. PLoS One, 2015. PMID 26270346, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis.
      Title: The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis.
    2. The PLEKHA7-PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells.
      Title: The PLEKHA7-PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells.
    3. PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis.
      Title: PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis.
    4. Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.
      Title: Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.
    5. PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.
      Title: PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.
    6. PLEKHA7, an Apical Adherens Junction Protein, Suppresses Inflammatory Breast Cancer in the Context of High E-Cadherin and p120-Catenin Expression.
      Title: PLEKHA7, an Apical Adherens Junction Protein, Suppresses Inflammatory Breast Cancer in the Context of High E-Cadherin and p120-Catenin Expression.
    7. Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.
      Title: Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33.
    8. Downregulation of PLEKHA7 in PACG may affect BAB integrity and aqueous humor outflow via its Rac1/Cdc42 GAP activity, thereby contributing to disease etiology.
      Title: Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function.
    9. our findings support a multi-layered role of PLEKHA7 in converging cytoskeletal dynamics and miRNA-mediated growth regulation at the ZA, with potentially critical implications in cancer that warrant further investigation.
      Title: PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications.
    10. These results show that the PLEKHA7-PDZD11 complex stabilizes nectins to promote efficient early junction assembly and uncover a new molecular mechanism through which PLEKHA7 recruits PDZ-binding membrane proteins to epithelial adherens junctions.
      Title: PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study of blood pressure and hypertension.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686B1134, DKFZp686M2234, DKFZp686M22243

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables delta-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in epithelial cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pore complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zonula adherens maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zonula adherens maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    part_of pore complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pore complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in zonula adherens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in zonula adherens IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 7
    Names
    PH domain-containing family A member 7
    pleckstrin homology domain containing, family A member 2
    pleckstrin homology domain containing, family A member 7
    pleckstrin homology domain-containing family A member 6

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329630.2 → NP_001316559.1  pleckstrin homology domain-containing family A member 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC026639, AC127033, BC032761, BC071599, BE873160, CN293588, DR731351
      Consensus CDS
      CCDS86182.1
      UniProtKB/TrEMBL
      A0A1B0GTN9, E9PKC0
      Related
      ENSP00000435389.1, ENST00000531066.6
      Conserved Domains (5) summary
      pfam06390
      Location:299 → 460
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:159 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:165 → 280
      PH; PH domain
      pfam00397
      Location:56 → 85
      WW; WW domain
      pfam07798
      Location:712 → 838
      DUF1640; Protein of unknown function (DUF1640)

    2. NM_001329631.2 → NP_001316560.1  pleckstrin homology domain-containing family A member 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC026639, AC116533, AC127033
      UniProtKB/TrEMBL
      A0A8Q3WLI9

    3. NM_001410960.1 → NP_001397889.1  pleckstrin homology domain-containing family A member 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC026639, AC116533, AC127033
      Consensus CDS
      CCDS91448.1
      UniProtKB/TrEMBL
      A0A1B0GTN9, A0A8V8TMS3
      Related
      ENSP00000513972.1, ENST00000698836.1

    4. NM_175058.5 → NP_778228.3  pleckstrin homology domain-containing family A member 7 isoform 2

      See identical proteins and their annotated locations for NP_778228.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC026639, AC127033, AW135567, BC071599, CN293588
      Consensus CDS
      CCDS31434.1
      UniProtKB/Swiss-Prot
      B4DK33, B4DWC3, Q6IQ23, Q86VZ7
      UniProtKB/TrEMBL
      A0A8Q3WLI9
      Related
      ENSP00000347883.2, ENST00000355661.7
      Conserved Domains (6) summary
      pfam06390
      Location:299 → 460
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd00890
      Location:656 → 743
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cd13248
      Location:159 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:165 → 280
      PH; PH domain
      pfam00397
      Location:56 → 85
      WW; WW domain
      pfam07798
      Location:712 → 838
      DUF1640; Protein of unknown function (DUF1640)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      16777297..17014414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426441.1 → XP_047282397.1  pleckstrin homology domain-containing family A member 7 isoform X24

      UniProtKB/TrEMBL
      A0A1B0GTN9

    2. XM_047426436.1 → XP_047282392.1  pleckstrin homology domain-containing family A member 7 isoform X17

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    3. XM_047426430.1 → XP_047282386.1  pleckstrin homology domain-containing family A member 7 isoform X7

      UniProtKB/TrEMBL
      A0A1B0GTN9

    4. XM_047426429.1 → XP_047282385.1  pleckstrin homology domain-containing family A member 7 isoform X6

      UniProtKB/TrEMBL
      A0A1B0GTN9

    5. XM_024448358.2 → XP_024304126.1  pleckstrin homology domain-containing family A member 7 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Conserved Domains (4) summary
      pfam06390
      Location:299 → 460
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:159 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:56 → 85
      WW; WW domain
      pfam07798
      Location:779 → 905
      DUF1640; Protein of unknown function (DUF1640)

    6. XM_047426439.1 → XP_047282395.1  pleckstrin homology domain-containing family A member 7 isoform X22

      UniProtKB/TrEMBL
      A0A1B0GTN9

    7. XM_047426435.1 → XP_047282391.1  pleckstrin homology domain-containing family A member 7 isoform X16

      UniProtKB/TrEMBL
      A0A1B0GTN9

    8. XM_047426432.1 → XP_047282388.1  pleckstrin homology domain-containing family A member 7 isoform X9

      UniProtKB/TrEMBL
      A0A1B0GTN9

    9. XM_047426431.1 → XP_047282387.1  pleckstrin homology domain-containing family A member 7 isoform X8

      UniProtKB/TrEMBL
      A0A1B0GTN9

    10. XM_047426428.1 → XP_047282384.1  pleckstrin homology domain-containing family A member 7 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GTN9

    11. XM_047426427.1 → XP_047282383.1  pleckstrin homology domain-containing family A member 7 isoform X4

      UniProtKB/TrEMBL
      A0A1B0GTN9

    12. XM_024448370.2 → XP_024304138.1  pleckstrin homology domain-containing family A member 7 isoform X13

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Conserved Domains (4) summary
      pfam06390
      Location:299 → 460
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:159 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:56 → 85
      WW; WW domain
      pfam07798
      Location:779 → 865
      DUF1640; Protein of unknown function (DUF1640)

    13. XM_024448357.2 → XP_024304125.1  pleckstrin homology domain-containing family A member 7 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Conserved Domains (4) summary
      pfam06390
      Location:299 → 460
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:159 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:56 → 85
      WW; WW domain
      pfam07798
      Location:779 → 905
      DUF1640; Protein of unknown function (DUF1640)

    14. XM_047426426.1 → XP_047282382.1  pleckstrin homology domain-containing family A member 7 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GTN9

    15. XM_047426437.1 → XP_047282393.1  pleckstrin homology domain-containing family A member 7 isoform X19

      UniProtKB/TrEMBL
      A0A1B0GTN9

    16. XM_047426434.1 → XP_047282390.1  pleckstrin homology domain-containing family A member 7 isoform X14

      UniProtKB/TrEMBL
      A0A1B0GTN9

    17. XM_024448361.2 → XP_024304129.1  pleckstrin homology domain-containing family A member 7 isoform X11

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Conserved Domains (2) summary
      cd13248
      Location:113 → 235
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam07798
      Location:733 → 859
      DUF1640; Protein of unknown function (DUF1640)

    18. XM_047426433.1 → XP_047282389.1  pleckstrin homology domain-containing family A member 7 isoform X10

      UniProtKB/TrEMBL
      A0A1B0GTN9

    19. XM_024448367.2 → XP_024304135.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Conserved Domains (3) summary
      pfam06390
      Location:193 → 354
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:53 → 175
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam07798
      Location:673 → 799
      DUF1640; Protein of unknown function (DUF1640)

    20. XM_024448366.2 → XP_024304134.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Conserved Domains (3) summary
      pfam06390
      Location:193 → 354
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:53 → 175
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam07798
      Location:673 → 799
      DUF1640; Protein of unknown function (DUF1640)

    21. XM_024448362.2 → XP_024304130.1  pleckstrin homology domain-containing family A member 7 isoform X12

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Conserved Domains (3) summary
      pfam06390
      Location:241 → 402
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:101 → 223
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam07798
      Location:721 → 847
      DUF1640; Protein of unknown function (DUF1640)

    22. XM_024448369.2 → XP_024304137.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Conserved Domains (3) summary
      pfam06390
      Location:193 → 354
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:53 → 175
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam07798
      Location:673 → 799
      DUF1640; Protein of unknown function (DUF1640)

    23. XM_024448365.2 → XP_024304133.1  pleckstrin homology domain-containing family A member 7 isoform X15

      UniProtKB/TrEMBL
      A0A1B0GTN9
      Related
      ENSP00000489780.1, ENST00000637162.1
      Conserved Domains (3) summary
      pfam06390
      Location:205 → 366
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd13248
      Location:65 → 187
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam07798
      Location:685 → 811
      DUF1640; Protein of unknown function (DUF1640)

    24. XM_047426438.1 → XP_047282394.1  pleckstrin homology domain-containing family A member 7 isoform X20

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    25. XM_047426444.1 → XP_047282400.1  pleckstrin homology domain-containing family A member 7 isoform X28

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    26. XM_017017242.3 → XP_016872731.1  pleckstrin homology domain-containing family A member 7 isoform X25

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    27. XM_047426440.1 → XP_047282396.1  pleckstrin homology domain-containing family A member 7 isoform X23

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    28. XM_017017241.3 → XP_016872730.1  pleckstrin homology domain-containing family A member 7 isoform X21

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    29. XM_047426447.1 → XP_047282403.1  pleckstrin homology domain-containing family A member 7 isoform X31

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    30. XM_047426443.1 → XP_047282399.1  pleckstrin homology domain-containing family A member 7 isoform X27

      UniProtKB/TrEMBL
      A0A8Q3WLI9
      Related
      ENSP00000512848.1, ENST00000696749.1

    31. XM_047426442.1 → XP_047282398.1  pleckstrin homology domain-containing family A member 7 isoform X26

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    32. XM_047426446.1 → XP_047282402.1  pleckstrin homology domain-containing family A member 7 isoform X30

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    33. XM_047426445.1 → XP_047282401.1  pleckstrin homology domain-containing family A member 7 isoform X29

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    RNA

    1. XR_007062454.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      16874672..17111588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367802.1 → XP_054223777.1  pleckstrin homology domain-containing family A member 7 isoform X24

      UniProtKB/TrEMBL
      A0A1B0GTN9

    2. XM_054367792.1 → XP_054223767.1  pleckstrin homology domain-containing family A member 7 isoform X17

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    3. XM_054367782.1 → XP_054223757.1  pleckstrin homology domain-containing family A member 7 isoform X7

      UniProtKB/TrEMBL
      A0A1B0GTN9

    4. XM_054367781.1 → XP_054223756.1  pleckstrin homology domain-containing family A member 7 isoform X6

      UniProtKB/TrEMBL
      A0A1B0GTN9

    5. XM_054367778.1 → XP_054223753.1  pleckstrin homology domain-containing family A member 7 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GTN9

    6. XM_054367791.1 → XP_054223766.1  pleckstrin homology domain-containing family A member 7 isoform X16

      UniProtKB/TrEMBL
      A0A1B0GTN9

    7. XM_054367800.1 → XP_054223775.1  pleckstrin homology domain-containing family A member 7 isoform X22

      UniProtKB/TrEMBL
      A0A1B0GTN9

    8. XM_054367784.1 → XP_054223759.1  pleckstrin homology domain-containing family A member 7 isoform X9

      UniProtKB/TrEMBL
      A0A1B0GTN9

    9. XM_054367783.1 → XP_054223758.1  pleckstrin homology domain-containing family A member 7 isoform X8

      UniProtKB/TrEMBL
      A0A1B0GTN9

    10. XM_054367780.1 → XP_054223755.1  pleckstrin homology domain-containing family A member 7 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GTN9

    11. XM_054367779.1 → XP_054223754.1  pleckstrin homology domain-containing family A member 7 isoform X4

      UniProtKB/TrEMBL
      A0A1B0GTN9

    12. XM_054367788.1 → XP_054223763.1  pleckstrin homology domain-containing family A member 7 isoform X13

      UniProtKB/TrEMBL
      A0A1B0GTN9

    13. XM_054367777.1 → XP_054223752.1  pleckstrin homology domain-containing family A member 7 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GTN9

    14. XM_054367776.1 → XP_054223751.1  pleckstrin homology domain-containing family A member 7 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GTN9

    15. XM_054367786.1 → XP_054223761.1  pleckstrin homology domain-containing family A member 7 isoform X11

      UniProtKB/TrEMBL
      A0A1B0GTN9

    16. XM_054367789.1 → XP_054223764.1  pleckstrin homology domain-containing family A member 7 isoform X14

      UniProtKB/TrEMBL
      A0A1B0GTN9

    17. XM_054367797.1 → XP_054223772.1  pleckstrin homology domain-containing family A member 7 isoform X19

      UniProtKB/TrEMBL
      A0A1B0GTN9

    18. XM_054367795.1 → XP_054223770.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      A0A1B0GTN9

    19. XM_054367785.1 → XP_054223760.1  pleckstrin homology domain-containing family A member 7 isoform X10

      UniProtKB/TrEMBL
      A0A1B0GTN9

    20. XM_054367794.1 → XP_054223769.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      A0A1B0GTN9

    21. XM_054367793.1 → XP_054223768.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      A0A1B0GTN9

    22. XM_054367787.1 → XP_054223762.1  pleckstrin homology domain-containing family A member 7 isoform X12

      UniProtKB/TrEMBL
      A0A1B0GTN9

    23. XM_054367796.1 → XP_054223771.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      A0A1B0GTN9

    24. XM_054367790.1 → XP_054223765.1  pleckstrin homology domain-containing family A member 7 isoform X15

      UniProtKB/TrEMBL
      A0A1B0GTN9

    25. XM_054367798.1 → XP_054223773.1  pleckstrin homology domain-containing family A member 7 isoform X20

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    26. XM_054367806.1 → XP_054223781.1  pleckstrin homology domain-containing family A member 7 isoform X28

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    27. XM_054367803.1 → XP_054223778.1  pleckstrin homology domain-containing family A member 7 isoform X25

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    28. XM_054367801.1 → XP_054223776.1  pleckstrin homology domain-containing family A member 7 isoform X23

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    29. XM_054367799.1 → XP_054223774.1  pleckstrin homology domain-containing family A member 7 isoform X21

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    30. XM_054367809.1 → XP_054223784.1  pleckstrin homology domain-containing family A member 7 isoform X31

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    31. XM_054367805.1 → XP_054223780.1  pleckstrin homology domain-containing family A member 7 isoform X27

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    32. XM_054367804.1 → XP_054223779.1  pleckstrin homology domain-containing family A member 7 isoform X26

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    33. XM_054367808.1 → XP_054223783.1  pleckstrin homology domain-containing family A member 7 isoform X30

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    34. XM_054367807.1 → XP_054223782.1  pleckstrin homology domain-containing family A member 7 isoform X29

      UniProtKB/TrEMBL
      A0A8Q3WLI9

    RNA

    1. XR_008488346.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IQ23.2 GenPept UniProtKB/Swiss-Prot:Q6IQ23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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