ADGRE5 adhesion G protein-coupled receptor E5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADGRE5provided by HGNC
Official Full Name: adhesion G protein-coupled receptor E5provided by HGNC
Primary source: HGNC:HGNC:1711
See related: Ensembl:ENSG00000123146 MIM:601211; AllianceGenome:HGNC:1711
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD97; TM7LN1
Summary: This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
Expression: Broad expression in bone marrow (RPKM 63.9), spleen (RPKM 54.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (14381444..14408723)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (14508134..14535397)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (14492256..14519535)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conformational transitions and activation of the adhesion receptor CD97.
Title: Conformational transitions and activation of the adhesion receptor CD97.
The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.
Title: The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.
Structural basis of CD97 activation and G-protein coupling.
Title: Structural basis of CD97 activation and G-protein coupling.
IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.
Title: IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.
CD97 expression level and its effect on cell adhesion in Preeclampsia.
Title: CD97 expression level and its effect on cell adhesion in Preeclampsia.
CD97 serves as a novel biomarker of immune cell infiltration in hepatocellular carcinoma.
Title: CD97 serves as a novel biomarker of immune cell infiltration in hepatocellular carcinoma.
To Detach, Migrate, Adhere, and Metastasize: CD97/ADGRE5 in Cancer.
Title: To Detach, Migrate, Adhere, and Metastasize: CD97/ADGRE5 in Cancer.
CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma.
Title: CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma.
Genetic manipulation of adhesion GPCR CD97/ADGRE5 modulates invasion in patient-derived glioma stem cells.
Title: Genetic manipulation of adhesion GPCR CD97/ADGRE5 modulates invasion in patient-derived glioma stem cells.
Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs.
Title: Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of CD97 molecule by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12356 (e-PCR)
- UniSTS:63566

STS-X84700 (e-PCR)
- UniSTS:9558

G63606 (e-PCR)
- UniSTS:140717

RH79172 (e-PCR)
- UniSTS:74960

G29823 (e-PCR)
- UniSTS:57082

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor E5

Names: CD97 molecule; leukocyte antigen CD97; seven transmembrane helix receptor; seven-span transmembrane protein; seven-transmembrane, heterodimeric receptor associated with inflammation

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029253.1 RefSeqGene

Range

5301..32580

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025160.3 → NP_001020331.1 adhesion G protein-coupled receptor E5 isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001020331.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3, also known as CD97(EGF 1,2,3,5)) is shorter than isoform 1.

Source sequence(s)

AK225655, AK292159

Consensus CDS

CCDS32930.1

UniProtKB/TrEMBL

B4DTS6

Related

ENSP00000349918.2, ENST00000357355.7

Conserved Domains (4) summary

smart00179
Location:116 → 148

EGF_CA; Calcium-binding EGF-like domain

pfam00002
Location:495 → 733

7tm_2; 7 transmembrane receptor (Secretin family)

pfam01825
Location:444 → 487

GPS; GPCR proteolysis site, GPS, motif

pfam07645
Location:160 → 194

EGF_CA; Calcium-binding EGF domain
NM_001784.6 → NP_001775.2 adhesion G protein-coupled receptor E5 isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001775.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2, also known as CD97(EGF 1,2,5)) is shorter than isoform 1.

Source sequence(s)

AC008569

Consensus CDS

CCDS32931.1

UniProtKB/TrEMBL

B3KUI0

Related

ENSP00000351413.2, ENST00000358600.7

Conserved Domains (4) summary

smart00303
Location:399 → 449

GPS; G-protein-coupled receptor proteolytic site domain

pfam07645
Location:116 → 150

EGF_CA; Calcium-binding EGF domain

cd14964
Location:454 → 478

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:451 → 713

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_078481.4 → NP_510966.1 adhesion G protein-coupled receptor E5 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_510966.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CD97(EGF 1,2,3,4,5)).

Source sequence(s)

AI890331, AK314697, U76764

Consensus CDS

CCDS32929.1

UniProtKB/Swiss-Prot

A8K7Z4, B2RBJ9, O00718, O76101, P48960, Q8NG72, Q8TBQ7

UniProtKB/TrEMBL

B4DTS6

Related

ENSP00000242786.4, ENST00000242786.6

Conserved Domains (5) summary

smart00179
Location:116 → 148

EGF_CA; Calcium-binding EGF-like domain

COG0477
Location:608 → 785

ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]

pfam00002
Location:544 → 782

7tm_2; 7 transmembrane receptor (Secretin family)

pfam01825
Location:493 → 536

GPS; GPCR proteolysis site, GPS, motif

pfam07645
Location:160 → 207

EGF_CA; Calcium-binding EGF domain