SULT1C3 sulfotransferase family 1C member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SULT1C3provided by HGNC
Official Full Name: sulfotransferase family 1C member 3provided by HGNC
Primary source: HGNC:HGNC:33543
See related: Ensembl:ENSG00000196228 MIM:617151; AllianceGenome:HGNC:33543
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ST1C3
Summary: Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and sulfotransferase activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cholesterol metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 2q12.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (108239968..108265351)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (108700880..108726238)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (108856424..108881807)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPARgamma regulatory network includes SULT1C3 and imply that this enzyme contributes to the control of such PPARgamma-regulated intestinal processes as growth, differentiation, and metabolism.
Title: Transcriptional Regulation of Human Cytosolic Sulfotransferase 1C3 by Peroxisome Proliferator-Activated Receptor γ in LS180 Human Colorectal Adenocarcinoma Cells.
Our findings are the first to characterize the regulation of human SULT1C2 and SULT1C3 expression by several transcription factor activators.
Title: Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells.
These data indicate that SULT1C3 is expressed in human intestine.
Title: Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables alcohol sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables aryl sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryl sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables bile-salt sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfur compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sulfotransferase 1C3

Names: sulfotransferase family, cytosolic, 1C, member 3

NP_001008743.1

EC 2.8.2.1

EC 2.8.2.2

NP_001307807.1

EC 2.8.2.1

EC 2.8.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008743.3 → NP_001008743.1 sulfotransferase 1C3 isoform 2

See identical proteins and their annotated locations for NP_001008743.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct C-terminus but is the same length as isoform 1.

Source sequence(s)

AC019100

Consensus CDS

CCDS33267.1

UniProtKB/Swiss-Prot

Q6IMI5, Q6IMI6

Related

ENSP00000333310.2, ENST00000329106.3

Conserved Domains (1) summary

pfam00685
Location:46 → 297

Sulfotransfer_1; Sulfotransferase domain
NM_001320878.2 → NP_001307807.1 sulfotransferase 1C3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (1).

Source sequence(s)

AC019100

Consensus CDS

CCDS92828.1

UniProtKB/Swiss-Prot

Q6IMI6

Related

ENSP00000505748.1, ENST00000681802.2

Conserved Domains (1) summary

pfam00685
Location:46 → 297

Sulfotransfer_1; Sulfotransferase domain

RNA

NR_178047.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant 1 but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding since the primary ORF has a stop codon >50 nucleotides from the terminal splice site; nonsense-mediated mRNA decay (NMD) candidate.

Source sequence(s)

CP068276