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    Slc5a9 solute carrier family 5 (sodium/glucose cotransporter), member 9 [ Mus musculus (house mouse) ]

    Gene ID: 230612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc5a9provided by MGI
    Official Full Name
    solute carrier family 5 (sodium/glucose cotransporter), member 9provided by MGI
    Primary source
    MGI:MGI:2140201
    See related
    Ensembl:ENSMUSG00000028544 AllianceGenome:MGI:2140201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGLT4
    Summary
    Predicted to enable D-glucose:sodium symporter activity. Predicted to be involved in sodium ion transport and transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human SLC5A9 (solute carrier family 5 member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 7.9), thymus adult (RPKM 7.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc5a9 in Genome Data Viewer
    Location:
    4 D1; 4 51.53 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111732571..111759993, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (111875374..111902796, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 6 Neighboring gene predicted gene 12961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:111490159-111490407 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11094 Neighboring gene STARR-seq mESC enhancer starr_11095 Neighboring gene selection and upkeep of intraepithelial T cells 8 Neighboring gene STARR-seq mESC enhancer starr_11097 Neighboring gene STARR-seq mESC enhancer starr_11098 Neighboring gene selection and upkeep of intraepithelial T cells 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Tazawa S, et al. Life Sci, 2005 Jan 14. PMID 15607332
    2. Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Wiley LM, et al. Dev Biol, 1991 Jan. PMID 1702069
    3. Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms. Li Y, et al. iScience, 2023 Dec 15. PMID 38089586, Free PMC Article
    4. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SGLT4 would have unique physiological functions (i.e., absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition to Glc).
      Title: SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29197

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium/glucose cotransporter 4
    Names
    Na(+)/glucose cotransporter 4
    mSGLT4
    solute carrier family 5 member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145551.4 → NP_663526.3  sodium/glucose cotransporter 4

      See identical proteins and their annotated locations for NP_663526.3

      Status: VALIDATED

      Source sequence(s)
      AI159731, AK028743, AK029158, AK033425
      Consensus CDS
      CCDS18474.1
      UniProtKB/Swiss-Prot
      Q8BGU9, Q8BZW1, Q8VDT1
      Related
      ENSMUSP00000099782.2, ENSMUST00000102721.8
      Conserved Domains (1) summary
      cl00456
      Location:45 → 685
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      111732571..111759993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503000.3 → XP_006503063.1  sodium/glucose cotransporter 4 isoform X1

      See identical proteins and their annotated locations for XP_006503063.1

      UniProtKB/Swiss-Prot
      Q8BGU9, Q8BZW1, Q8VDT1
      Related
      ENSMUSP00000099780.2, ENSMUST00000102719.8
      Conserved Domains (1) summary
      cl00456
      Location:45 → 685
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_006503001.2 → XP_006503064.1  sodium/glucose cotransporter 4 isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:1 → 593
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_006503002.4 → XP_006503065.1  sodium/glucose cotransporter 4 isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:45 → 377
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_376307.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDT1.3 GenPept UniProtKB/Swiss-Prot:Q8VDT1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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