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    Skint7 selection and upkeep of intraepithelial T cells 7 [ Mus musculus (house mouse) ]

    Gene ID: 328505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Skint7provided by MGI
    Official Full Name
    selection and upkeep of intraepithelial T cells 7provided by MGI
    Primary source
    MGI:MGI:3041190
    See related
    Ensembl:ENSMUSG00000049214 AllianceGenome:MGI:3041190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130057D23Rik
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; liver; and thymus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Skint7 in Genome Data Viewer
    Location:
    4 D1; 4 51.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111830121..111845457)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (111972924..111988260)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11095 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 9 Neighboring gene selection and upkeep of intraepithelial T cells 8 Neighboring gene STARR-seq mESC enhancer starr_11097 Neighboring gene STARR-seq mESC enhancer starr_11098 Neighboring gene selection and upkeep of intraepithelial T cells 1 Neighboring gene STARR-seq mESC enhancer starr_11099 Neighboring gene selection and upkeep of intraepithelial T cells 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Boyden LM, et al. Nat Genet, 2008 May. PMID 18408721, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    selection and upkeep of intraepithelial T-cells protein 7
    Names
    novel immunoglobulin V-set and CD80-like C2-set immunoglobulin domain containing protein
    skint 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142775.1 → NP_001136247.1  selection and upkeep of intraepithelial T-cells protein 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001136247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BB614300, EU099306
      Consensus CDS
      CCDS51266.1
      UniProtKB/Swiss-Prot
      A7TZF5, A7TZF6, A7TZF7, A7TZF8, A7XV04, E9Q3C9, M9MMJ4
      Related
      ENSMUSP00000127347.2, ENSMUST00000163281.2
      Conserved Domains (2) summary
      cd05713
      Location:42 → 141
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:35 → 140
      IG_like; Immunoglobulin like

    2. NM_177818.3 → NP_808486.2  selection and upkeep of intraepithelial T-cells protein 7 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a few of 3' exons but has an alternate 3' end, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK048392, AV252647, BB614300
      Consensus CDS
      CCDS18475.1
      UniProtKB/Swiss-Prot
      A7XV04
      Related
      ENSMUSP00000054822.5, ENSMUST00000055014.11
      Conserved Domains (2) summary
      cd05713
      Location:42 → 141
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:35 → 140
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      111830121..111845457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240555.1 → XP_011238857.1  selection and upkeep of intraepithelial T-cells protein 7 isoform X1

      Conserved Domains (1) summary
      cd05713
      Location:42 → 141
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

    2. XM_006503172.2 → XP_006503235.1  selection and upkeep of intraepithelial T-cells protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J1K7
      Related
      ENSMUSP00000102178.2, ENSMUST00000106568.8
      Conserved Domains (1) summary
      cd05713
      Location:42 → 141
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

    3. XM_006503173.2 → XP_006503236.1  selection and upkeep of intraepithelial T-cells protein 7 isoform X3

      Conserved Domains (1) summary
      cd05713
      Location:42 → 141
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7XV04.2 GenPept UniProtKB/Swiss-Prot:A7XV04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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