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    Dyrk1a dual-specificity tyrosine phosphorylation regulated kinase 1a [ Mus musculus (house mouse) ]

    Gene ID: 13548, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dyrk1aprovided by MGI
    Official Full Name
    dual-specificity tyrosine phosphorylation regulated kinase 1aprovided by MGI
    Primary source
    MGI:MGI:1330299
    See related
    Ensembl:ENSMUSG00000022897 AllianceGenome:MGI:1330299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik
    Summary
    Enables identical protein binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of microtubule polymerization; and protein phosphorylation. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; cytoskeleton; and dendrite. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Used to study Down syndrome and autosomal dominant intellectual developmental disorder 7. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.2), whole brain E14.5 (RPKM 10.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dyrk1a in Genome Data Viewer
    Location:
    16 C4; 16 55.3 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (94370770..94496378)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (94569947..94695519)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 3 Neighboring gene predicted gene, 23692 Neighboring gene predicted gene, 31323 Neighboring gene STARR-positive B cell enhancer ABC_E1498 Neighboring gene STARR-positive B cell enhancer ABC_E9431 Neighboring gene VPS26 endosomal protein sorting factor C Neighboring gene STARR-seq mESC enhancer starr_41576 Neighboring gene STARR-seq mESC enhancer starr_41578 Neighboring gene STARR-positive B cell enhancer ABC_E5566 Neighboring gene STARR-positive B cell enhancer mm9_chr16:94853523-94853824 Neighboring gene predicted gene, 53922 Neighboring gene predicted gene, 41504 Neighboring gene predicted gene, 41505 Neighboring gene predicted gene, 41507

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC150253, MGC150254

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tau protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with neurofilament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 1A
    Names
    dual specificity YAK1-related kinase
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
    protein kinase minibrain homolog
    NP_001106860.1
    NP_001334660.1
    NP_001389720.1
    NP_001389721.1
    NP_001389722.1
    NP_031916.1
    XP_011244397.1
    XP_036015668.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113389.1NP_001106860.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

      See identical proteins and their annotated locations for NP_001106860.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' non-coding exon, therefore, has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK052390, AK163136, BC129888, CB526389, CX566606
      Consensus CDS
      CCDS28350.1
      UniProtKB/Swiss-Prot
      Q61214
      UniProtKB/TrEMBL
      A9C475
      Related
      ENSMUSP00000023614.5, ENSMUST00000023614.5
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    2. NM_001347731.2NP_001334660.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165271, CT030190
      UniProtKB/TrEMBL
      A1L341
      Conserved Domains (1) summary
      cd14226
      Location:139475
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    3. NM_001402791.1NP_001389720.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165271, CT030190
      UniProtKB/Swiss-Prot
      Q61214
      UniProtKB/TrEMBL
      A9C475
    4. NM_001402792.1NP_001389721.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165271, CT030190
      UniProtKB/TrEMBL
      Q8K006
    5. NM_001402793.1NP_001389722.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165271, CT030190
      UniProtKB/TrEMBL
      F6U6X3, Q8K006
      Related
      ENSMUSP00000112853.3, ENSMUST00000122284.9
    6. NM_007890.2NP_031916.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

      See identical proteins and their annotated locations for NP_031916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK052390, AK163136, BC129888, BF462682, CD540384, CX566606
      Consensus CDS
      CCDS28350.1
      UniProtKB/Swiss-Prot
      Q61214
      UniProtKB/TrEMBL
      A9C475
      Related
      ENSMUSP00000113660.2, ENSMUST00000119878.8
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      94370770..94496378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159775.1XP_036015668.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

      UniProtKB/TrEMBL
      A1L341
      Conserved Domains (1) summary
      cd14226
      Location:139475
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    2. XM_011246095.4XP_011244397.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

      See identical proteins and their annotated locations for XP_011244397.1

      UniProtKB/Swiss-Prot
      Q61214
      UniProtKB/TrEMBL
      A9C475
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1