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    Iqank1 IQ motif and ankyrin repeat containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 432964, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Iqank1provided by MGI
    Official Full Name
    IQ motif and ankyrin repeat containing 1provided by MGI
    Primary source
    MGI:MGI:3588184
    See related
    Ensembl:ENSMUSG00000102018 AllianceGenome:MGI:3588184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933407E14Rik; K230010J24Rik
    Summary
    Predicted to be active in cytoplasm and nucleus. Orthologous to human IQANK1 (IQ motif and ankyrin repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 22.0), genital fat pad adult (RPKM 3.3) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Iqank1 in Genome Data Viewer
    Location:
    15 D3; 15 35.23 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75881320..75918830)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76009435..76046981)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 166 Neighboring gene mitogen-activated protein kinase 15 Neighboring gene family with sequence similarity 83, member H Neighboring gene scribbled planar cell polarity Neighboring gene microRNA 6952 Neighboring gene STARR-seq mESC enhancer starr_39038 Neighboring gene poly-U binding splicing factor 60

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    IQ motif and ankyrin repeat domain-containing protein 1
    Names
    putative IQ motif and ankyrin repeat domain-containing protein LOC642574 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370920.1 → NP_001357849.1  IQ motif and ankyrin repeat domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Consensus CDS
      CCDS88783.1
      UniProtKB/Swiss-Prot
      A0A140LHX0, Q3TYL0
      UniProtKB/TrEMBL
      A0A7D9N0L4
      Related
      ENSMUSP00000146582.2, ENSMUST00000187868.3
      Conserved Domains (5) summary
      pfam05262
      Location:287 → 400
      Borrelia_P83; Borrelia P83/100 protein
      COG0666
      Location:192 → 314
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:191 → 222
      ANK; ANK repeat [structural motif]
      pfam12781
      Location:427 → 479
      AAA_9; ATP-binding dynein motor region D5
      pfam13637
      Location:192 → 245
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75881320..75918830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248636.2 → XP_030104496.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      pfam12781
      Location:143 → 193
      AAA_9; ATP-binding dynein motor region D5
      NF033930
      Location:8 → 125
      pneumo_PspA; pneumococcal surface protein A

    2. XM_030248629.2 → XP_030104489.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A0A140LHX0, Q3TYL0
      UniProtKB/TrEMBL
      A0A7D9N0L4
      Conserved Domains (5) summary
      pfam05262
      Location:287 → 400
      Borrelia_P83; Borrelia P83/100 protein
      COG0666
      Location:192 → 314
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:191 → 222
      ANK; ANK repeat [structural motif]
      pfam12781
      Location:427 → 479
      AAA_9; ATP-binding dynein motor region D5
      pfam13637
      Location:192 → 245
      Ank_4; Ankyrin repeats (many copies)

    3. XM_036159485.1 → XP_036015378.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      pfam12781
      Location:143 → 193
      AAA_9; ATP-binding dynein motor region D5
      NF033930
      Location:8 → 125
      pneumo_PspA; pneumococcal surface protein A

    4. XM_036159484.1 → XP_036015377.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      pfam12781
      Location:143 → 193
      AAA_9; ATP-binding dynein motor region D5
      NF033930
      Location:8 → 125
      pneumo_PspA; pneumococcal surface protein A

    5. XM_030248634.1 → XP_030104494.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      pfam05262
      Location:36 → 149
      Borrelia_P83; Borrelia P83/100 protein
      pfam12781
      Location:176 → 228
      AAA_9; ATP-binding dynein motor region D5

    6. XM_036159483.1 → XP_036015376.1  IQ motif and ankyrin repeat domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A0A140LHX0, Q3TYL0
      Conserved Domains (5) summary
      COG0666
      Location:170 → 292
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:169 → 200
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:170 → 223
      Ank_4; Ankyrin repeats (many copies)
      pfam12781
      Location:405 → 455
      AAA_9; ATP-binding dynein motor region D5
      NF033930
      Location:237 → 387
      pneumo_PspA; pneumococcal surface protein A

    RNA

    1. XR_004938850.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TYL0.3 GenPept UniProtKB/Swiss-Prot:Q3TYL0

    Gene LinkOut

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