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    Med13l mediator complex subunit 13L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Med13lprovided by RGD
    Official Full Name
    mediator complex subunit 13Lprovided by RGD
    Primary source
    RGD:1305884
    See related
    EnsemblRapid:ENSRNOG00000001120 AllianceGenome:RGD:1305884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Thrap2
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Human ortholog(s) of this gene implicated in dextro-looped transposition of the great arteries. Orthologous to human MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 98.1), Lung (RPKM 96.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med13l in Genome Data Viewer
    Location:
    12q16
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (43468556..43665819, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (37807596..38004886, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (43421317..43576859, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481203 Neighboring gene uncharacterized LOC108352455 Neighboring gene uncharacterized LOC120095989 Neighboring gene uncharacterized LOC102552816 Neighboring gene uncharacterized LOC102552995

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries). Muncke N, et al. Circulation, 2003 Dec 9. PMID 14638541
    2. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. Ito M, et al. EMBO J, 2002 Jul 1. PMID 12093747, Free PMC Article
    3. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 13-like
    Names
    mediator complex subunit 13-like
    thyroid hormone receptor associated protein 2
    thyroid hormone receptor-associated 240-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419791.1 → NP_001406720.1  mediator of RNA polymerase II transcription subunit 13-like

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      D4P4K6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      43468556..43665819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090173.2 → XP_038946101.1  mediator of RNA polymerase II transcription subunit 13-like isoform X2

      UniProtKB/TrEMBL
      D4P4K6
      Conserved Domains (4) summary
      PHA03247
      Location:549 → 857
      PHA03247; large tegument protein UL36; Provisional
      pfam06333
      Location:1791 → 2203
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam11597
      Location:11 → 223
      Med13_N; Mediator complex subunit 13 N-terminal
      pfam18296
      Location:1418 → 1755
      MID_MedPIWI; MID domain of medPIWI

    2. XM_039090172.2 → XP_038946100.1  mediator of RNA polymerase II transcription subunit 13-like isoform X1

      UniProtKB/TrEMBL
      A0A8I6AID1, D4P4K6
      Related
      ENSRNOP00000046404.6, ENSRNOT00000042331.6
      Conserved Domains (5) summary
      PHA03247
      Location:549 → 877
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:739 → 1107
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06333
      Location:1792 → 2204
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam11597
      Location:11 → 223
      Med13_N; Mediator complex subunit 13 N-terminal
      pfam18296
      Location:1419 → 1756
      MID_MedPIWI; MID domain of medPIWI

    3. XM_039090175.2 → XP_038946103.1  mediator of RNA polymerase II transcription subunit 13-like isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5R7
      Related
      ENSRNOP00000073531.1, ENSRNOT00000078445.3
      Conserved Domains (4) summary
      PHA03247
      Location:415 → 743
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:605 → 973
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06333
      Location:1658 → 2070
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam18296
      Location:1285 → 1622
      MID_MedPIWI; MID domain of medPIWI

    4. XM_063271538.1 → XP_063127608.1  mediator of RNA polymerase II transcription subunit 13-like isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5R7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108337.1: Suppressed sequence

      Description
      NM_001108337.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MED13L (GeneID:23389).
    Nucleotide Protein Strain
    Heading Accession and Version

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