BAIAP2 BAR/IMD domain containing adaptor protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BAIAP2provided by HGNC
Official Full Name: BAR/IMD domain containing adaptor protein 2provided by HGNC
Primary source: HGNC:HGNC:947
See related: Ensembl:ENSG00000175866 MIM:605475; AllianceGenome:HGNC:947
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAP2; WAML; FLAF3; IRSP53
Summary: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Expression: Broad expression in brain (RPKM 10.7), skin (RPKM 9.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (81035151..81117434)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (81943527..82025893)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (79008951..79091234)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation.
Title: BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation.
Actin Filaments Couple the Protrusive Tips to the Nucleus through the I-BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers.
Title: Actin Filaments Couple the Protrusive Tips to the Nucleus through the I-BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers.
Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.
Title: Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.
Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin.
Title: Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin.
IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.
Title: IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.
BAIAP2 rs8079781, postnatal smoking exposure, and emotional problems in Japanese children aged 5 years: the Kyushu Okinawa Maternal and Child Health Study.
Title: BAIAP2 rs8079781, postnatal smoking exposure, and emotional problems in Japanese children aged 5 years: the Kyushu Okinawa Maternal and Child Health Study.
Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-kappaB and Impaired Mobility of HUVECs.
Title: Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-κB and Impaired Mobility of HUVECs.
Phosphorylation-dependent inhibition of IRSp53 by 14-3-3 counters activation by Cdc42 and cytoskeletal effectors, resulting in down-regulation of filopodia dynamics and cancer cell migration. In serum-starved cells, increased IRSp53 phosphorylation triggers 14-3-3 binding, which inhibits filopodia formation and dynamics, irrespective of whether IRSp53 is activated by Cdc42 or downstream effectors (Eps8, Ena/VASP).
Title: IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration.
IRSp53 heterodimer with only one subunit is phosphorylated, and each subunit of IRSp53 independently binds one 14-3-3 dimer.
Title: Mechanism of IRSp53 inhibition by 14-3-3.
Coincident with the loss of PICK1 by GBF1-activated ARF1, CDC42 recruitment leads to the activation of IRSp53 and the ARP2/3 complex, resulting in a burst of F-actin polymerisation potentially powering scission.
Title: Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
BAIAP2 is related to emotional modulation of human memory strength. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 VLP production/release from Jurkat T lymphocytes requires an intact RAC1-WASF2-BAIAP2-ARP3 pathway as demonstrated by siRNA knockdown experiments	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion	PubMed
Pr55(Gag)	gag	HIV-1 Gag is required by RAC1-WASF2-BAIAP2-ARP3 pathway for HIV VLP production/release from Jurkat T lymphocytes	PubMed
	gag	HIV-1 Gag intracellular localization is modulated by WASF2 and BAIAP2 as demonstrated by double siRNA knockdowns of these cellular proteins (in Jurkat T cells)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-147371 (e-PCR)
- UniSTS:183044

SHGC-149058 (e-PCR)
- UniSTS:173098

RH36794 (e-PCR)
- UniSTS:86630

RH15981 (e-PCR)
- UniSTS:71529

RH102309 (e-PCR)
- UniSTS:96643

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding involved in cell-cell adhesion	HDA more info	PubMed
enables cytoskeletal anchor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proline-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin crosslink formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in axonogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-glutamate	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in plasma membrane organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in protein localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
colocalizes_with actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	HDA more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic spine cytoplasm	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuron projection branch point	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in postsynaptic cytosol	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density, intracellular component	IEA Inferred from Electronic Annotation more info
located_in presynaptic cytosol	IEA Inferred from Electronic Annotation more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BAR/IMD domain-containing adapter protein 2

Names: BAI1 associated protein 2; IRS-58; IRSp53/58; WASP and MIM like; brain-specific angiogenesis inhibitor 1-associated protein 2; fas ligand-associated factor 3; insulin receptor substrate of 53 kDa; insulin receptor substrate p53/p58; insulin receptor substrate protein of 53 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029486.2 RefSeqGene

Range

5005..87288

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144888.2 → NP_001138360.1 BAR/IMD domain-containing adapter protein 2 isoform 4

See identical proteins and their annotated locations for NP_001138360.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) shares identical sequence with variants 1, 2 and 3, but diverges after amino acid 511 resulting in a distinct 23 amino acid sequence at the C-terminus. This transcript variant encodes isoform 4 and is alternatively referred to as variant M.

Source sequence(s)

AC115099, BC002495, CB153324

Consensus CDS

CCDS45806.1

UniProtKB/TrEMBL

B4DMV0

Related

ENSP00000401022.2, ENST00000428708.7

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385127.1 → NP_001372056.1 BAR/IMD domain-containing adapter protein 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.

Source sequence(s)

AC115099, AC127496

Consensus CDS

CCDS11775.1

UniProtKB/Swiss-Prot

O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43, Q9UQB8

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385128.1 → NP_001372057.1 BAR/IMD domain-containing adapter protein 2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variant 3, encodes isoform 3.

Source sequence(s)

AC115099, AC127496

Consensus CDS

CCDS11776.1

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385129.1 → NP_001372058.1 BAR/IMD domain-containing adapter protein 2 isoform 5

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:410 → 468

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385130.1 → NP_001372059.1 BAR/IMD domain-containing adapter protein 2 isoform 6

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:410 → 468

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385131.1 → NP_001372060.1 BAR/IMD domain-containing adapter protein 2 isoform 7

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385132.1 → NP_001372061.1 BAR/IMD domain-containing adapter protein 2 isoform 8

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:410 → 468

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385133.1 → NP_001372062.1 BAR/IMD domain-containing adapter protein 2 isoform 9

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:411 → 469

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385134.1 → NP_001372063.1 BAR/IMD domain-containing adapter protein 2 isoform 10

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:410 → 468

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385135.1 → NP_001372064.1 BAR/IMD domain-containing adapter protein 2 isoform 11

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:411 → 469

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385136.1 → NP_001372065.1 BAR/IMD domain-containing adapter protein 2 isoform 12

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

Consensus CDS

CCDS92414.1

UniProtKB/TrEMBL

B4DMV0, I3L4C2

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:410 → 468

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385137.1 → NP_001372066.1 BAR/IMD domain-containing adapter protein 2 isoform 13

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 261

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:403 → 461

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385138.1 → NP_001372067.1 BAR/IMD domain-containing adapter protein 2 isoform 14

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:378 → 436

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385139.1 → NP_001372068.1 BAR/IMD domain-containing adapter protein 2 isoform 15

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385140.1 → NP_001372069.1 BAR/IMD domain-containing adapter protein 2 isoform 16

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:378 → 436

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385141.1 → NP_001372070.1 BAR/IMD domain-containing adapter protein 2 isoform 17

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:378 → 436

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385144.1 → NP_001372073.1 BAR/IMD domain-containing adapter protein 2 isoform 18

Status: REVIEWED

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 234

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:375 → 433

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385145.1 → NP_001372074.1 BAR/IMD domain-containing adapter protein 2 isoform 19

Status: REVIEWED

Description

Transcript Variant: This variant (21), as well as variant 22, encodes isoform 19.

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385146.1 → NP_001372075.1 BAR/IMD domain-containing adapter protein 2 isoform 19

Status: REVIEWED

Description

Transcript Variant: This variant (22), as well as variant 21, encodes isoform 19.

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DMV0

Related

ENSP00000458964.1, ENST00000575712.5

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385147.1 → NP_001372076.1 BAR/IMD domain-containing adapter protein 2 isoform 20

Status: REVIEWED

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:319 → 377

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 178

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385148.1 → NP_001372077.1 BAR/IMD domain-containing adapter protein 2 isoform 21

Status: REVIEWED

Description

Transcript Variant: This variant (24), as well as variant 25, encodes isoform 21.

Source sequence(s)

AC115099, AC127496

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:319 → 377

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 178

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385149.1 → NP_001372078.1 BAR/IMD domain-containing adapter protein 2 isoform 21

Status: REVIEWED

Description

Transcript Variant: This variant (25), as well as variant 24, encodes isoform 21.

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:319 → 377

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 178

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385150.1 → NP_001372079.1 BAR/IMD domain-containing adapter protein 2 isoform 22

Status: REVIEWED

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:299 → 357

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385151.1 → NP_001372080.1 BAR/IMD domain-containing adapter protein 2 isoform 23

Status: REVIEWED

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:300 → 358

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385152.1 → NP_001372081.1 BAR/IMD domain-containing adapter protein 2 isoform 24

Status: REVIEWED

Description

Transcript Variant: This variant (28), as well as variant 29, encodes isoform 24.

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:299 → 357

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385153.1 → NP_001372082.1 BAR/IMD domain-containing adapter protein 2 isoform 24

Status: REVIEWED

Description

Transcript Variant: This variant (29), as well as variant 28, encodes isoform 24.

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:299 → 357

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385154.1 → NP_001372083.1 BAR/IMD domain-containing adapter protein 2 isoform 25

Status: REVIEWED

Description

Transcript Variant: This variant (30), as well as variants 31 and 32, encodes isoform 25.

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:299 → 357

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385155.1 → NP_001372084.1 BAR/IMD domain-containing adapter protein 2 isoform 25

Status: REVIEWED

Description

Transcript Variant: This variant (31), as well as variants 30 and 32, encodes isoform 25.

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:299 → 357

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385156.1 → NP_001372085.1 BAR/IMD domain-containing adapter protein 2 isoform 25

Status: REVIEWED

Description

Transcript Variant: This variant (32), as well as variants 30 and 31, encodes isoform 25.

Source sequence(s)

AC115099

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:299 → 357

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001385157.1 → NP_001372086.1 BAR/IMD domain-containing adapter protein 2 isoform 26

Status: REVIEWED

Source sequence(s)

AC115099

Conserved Domains (1) summary

cd11915
Location:134 → 192

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385158.1 → NP_001372087.1 BAR/IMD domain-containing adapter protein 2 isoform 27

Status: REVIEWED

Description

Transcript Variant: This variant (34), as well as variant 35, encodes isoform 27.

Source sequence(s)

AC115099

Conserved Domains (1) summary

cd11915
Location:134 → 192

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_001385159.1 → NP_001372088.1 BAR/IMD domain-containing adapter protein 2 isoform 27

Status: REVIEWED

Description

Transcript Variant: This variant (35), as well as variant 34, encodes isoform 27.

Source sequence(s)

AC115099

Conserved Domains (1) summary

cd11915
Location:134 → 192

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_006340.3 → NP_006331.1 BAR/IMD domain-containing adapter protein 2 isoform 3

See identical proteins and their annotated locations for NP_006331.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) shares identical sequence with variants 1, 2 and 4, but diverges after amino acid 511 resulting in a distinct 9 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-beta or variant T. Variants 3 and 6 both encode the same isoform (3).

Source sequence(s)

AB015020, AC115099, BC002495, CB153324

Consensus CDS

CCDS11776.1

UniProtKB/TrEMBL

B4DMV0

Related

ENSP00000413069.3, ENST00000435091.7

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_017450.3 → NP_059344.1 BAR/IMD domain-containing adapter protein 2 isoform 1

See identical proteins and their annotated locations for NP_059344.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) shares identical sequence with variants 2, 3 and 4, but diverges after amino acid 511 resulting in a distinct 10 amino acid sequence at the C-terminus. This transcript variant encodes isoform 1 and is alternatively referred to as BAP2-alpha, short form, or variant S.

Source sequence(s)

AC115099, BC002495, CB153324

Consensus CDS

CCDS11777.1

UniProtKB/TrEMBL

B4DMV0

Related

ENSP00000315685.7, ENST00000321280.11

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
NM_017451.3 → NP_059345.1 BAR/IMD domain-containing adapter protein 2 isoform 2

See identical proteins and their annotated locations for NP_059345.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) shares identical sequence with variants 1, 3 and 4, but diverges after amino acid 511 resulting in a distinct 41 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as the long form or variant L. Variants 2 and 5 both encode the same isoform (2).

Source sequence(s)

AC115099, BC002495, CB153324

Consensus CDS

CCDS11775.1

UniProtKB/Swiss-Prot

O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43, Q9UQB8

UniProtKB/TrEMBL

B4DMV0

Related

ENSP00000316338.6, ENST00000321300.10

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:377 → 435

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

RNA

NR_169574.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC115099, AC127496
NR_169575.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC115099, AC127496
NR_169576.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC115099, AC127496
NR_169577.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC115099, AC127496
NR_169578.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC115099, AC127496
NR_169579.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC115099, AC127496
NR_169580.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC115099

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

81035151..81117434

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011524193.2 → XP_011522495.1 BAR/IMD domain-containing adapter protein 2 isoform X2

See identical proteins and their annotated locations for XP_011522495.1

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:411 → 469

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
XM_011524194.2 → XP_011522496.1 BAR/IMD domain-containing adapter protein 2 isoform X1

UniProtKB/TrEMBL

B4DMV0

Conserved Domains (2) summary

cd07646
Location:5 → 269

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:411 → 469

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
XM_047435112.1 → XP_047291068.1 BAR/IMD domain-containing adapter protein 2 isoform X3

UniProtKB/TrEMBL

I3L4C2

Related

ENSP00000461144.1, ENST00000575245.5
XM_017024017.2 → XP_016879506.2 BAR/IMD domain-containing adapter protein 2 isoform X4
XM_047435113.1 → XP_047291069.1 BAR/IMD domain-containing adapter protein 2 isoform X5
XM_017024018.2 → XP_016879507.1 BAR/IMD domain-containing adapter protein 2 isoform X6

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:300 → 358

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_024450535.2 → XP_024306303.1 BAR/IMD domain-containing adapter protein 2 isoform X6

UniProtKB/TrEMBL

B4DQ43

Conserved Domains (2) summary

cd11915
Location:300 → 358

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 158

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017024019.2 → XP_016879508.1 BAR/IMD domain-containing adapter protein 2 isoform X7

Conserved Domains (1) summary

cd11915
Location:135 → 193

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
XM_011524195.2 → XP_011522497.1 BAR/IMD domain-containing adapter protein 2 isoform X7

See identical proteins and their annotated locations for XP_011522497.1

Conserved Domains (1) summary

cd11915
Location:135 → 193

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
XM_011524196.2 → XP_011522498.1 BAR/IMD domain-containing adapter protein 2 isoform X7

See identical proteins and their annotated locations for XP_011522498.1

Conserved Domains (1) summary

cd11915
Location:135 → 193

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

81943527..82025893

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314691.1 → XP_054170666.1 BAR/IMD domain-containing adapter protein 2 isoform X2
XM_054314690.1 → XP_054170665.1 BAR/IMD domain-containing adapter protein 2 isoform X1
XM_054314692.1 → XP_054170667.1 BAR/IMD domain-containing adapter protein 2 isoform X3

UniProtKB/TrEMBL

I3L4C2
XM_054314693.1 → XP_054170668.1 BAR/IMD domain-containing adapter protein 2 isoform X4
XM_054314694.1 → XP_054170669.1 BAR/IMD domain-containing adapter protein 2 isoform X5
XM_054314695.1 → XP_054170670.1 BAR/IMD domain-containing adapter protein 2 isoform X6
XM_054314696.1 → XP_054170671.1 BAR/IMD domain-containing adapter protein 2 isoform X6
XM_054314699.1 → XP_054170674.1 BAR/IMD domain-containing adapter protein 2 isoform X7
XM_054314697.1 → XP_054170672.1 BAR/IMD domain-containing adapter protein 2 isoform X7
XM_054314698.1 → XP_054170673.1 BAR/IMD domain-containing adapter protein 2 isoform X7