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    ZNF263 zinc finger protein 263 [ Homo sapiens (human) ]

    Gene ID: 10127, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF263provided by HGNC
    Official Full Name
    zinc finger protein 263provided by HGNC
    Primary source
    HGNC:HGNC:13056
    See related
    Ensembl:ENSG00000006194 MIM:604191; AllianceGenome:HGNC:13056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPM315; ZSCAN44; ZKSCAN12
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 7.9), testis (RPKM 7.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF263 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3283491..3301401)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3290853..3328457)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3333491..3351401)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:3293322-3294521 Neighboring gene MEFV innate immunity regulator, pyrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10318 Neighboring gene long intergenic non-protein coding RNA 921 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3332464-3332969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7131 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3333980-3334483 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3354991-3355520 Neighboring gene tigger transposable element derived 7 Neighboring gene zinc finger protein 75A Neighboring gene RPL7L1 pseudogene 19 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:3414288-3415487 Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-CO2 pseudogene 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma. Liang J, et al. Cell Rep, 2024 Feb 27. PMID 38335093
    2. ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. Weiss RJ, et al. Proc Natl Acad Sci U S A, 2020 Apr 28. PMID 32277030, Free PMC Article
    3. Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance. Du Y, et al. Sci Rep, 2024 Sep 18. PMID 39294234, Free PMC Article
    4. Zinc finger protein 263 upregulates interleukin 33 and suppresses autophagy to accelerate the malignant progression of non-small cell lung cancer. Xu J, et al. Clin Transl Oncol, 2024 Apr. PMID 37821764
    5. Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263. Wang L, et al. Oncogene, 2023 Jul. PMID 37353617

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance.
      Title: Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance.
    2. Zinc finger protein 263 upregulates interleukin 33 and suppresses autophagy to accelerate the malignant progression of non-small cell lung cancer.
      Title: Zinc finger protein 263 upregulates interleukin 33 and suppresses autophagy to accelerate the malignant progression of non-small cell lung cancer.
    3. Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.
      Title: Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.
    4. Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.
      Title: Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.
    5. Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p.
      Title: Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p.
    6. The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
      Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
    7. ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.
      Title: ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.
    8. Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263.
      Title: Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 263
    Names
    zinc finger protein FPM315
    zinc finger protein with KRAB and SCAN domains 12

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411015.1 → NP_001397944.1  zinc finger protein 263 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004232
      Consensus CDS
      CCDS92094.1
      UniProtKB/TrEMBL
      D3DUC1, I3L4C4, I3L538
      Related
      ENSP00000461755.2, ENST00000574674.2

    2. NM_005741.5 → NP_005732.2  zinc finger protein 263 isoform 1

      See identical proteins and their annotated locations for NP_005732.2

      Status: VALIDATED

      Source sequence(s)
      AK312421, BC008805
      Consensus CDS
      CCDS10499.1
      UniProtKB/Swiss-Prot
      B2R634, O14978, O43387, Q96H95
      Related
      ENSP00000219069.5, ENST00000219069.6
      Conserved Domains (6) summary
      smart00431
      Location:38 → 149
      SCAN; leucine rich region
      smart00349
      Location:218 → 277
      KRAB; krueppel associated box
      COG5048
      Location:434 → 649
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436 → 456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:380 → 400
      zf-C2H2; Zinc finger, C2H2 type
      pfam15498
      Location:128 → 347
      Dendrin; Nephrin and CD2AP-binding protein, Dendrin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3283491..3301401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3290853..3328457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379359.1 → XP_054235334.1  zinc finger protein 263 isoform X1

      UniProtKB/Swiss-Prot
      B2R634, O14978, O43387, Q96H95

    2. XM_054379360.1 → XP_054235335.1  zinc finger protein 263 isoform X1

      UniProtKB/Swiss-Prot
      B2R634, O14978, O43387, Q96H95

    3. XM_054379362.1 → XP_054235337.1  zinc finger protein 263 isoform X3

    4. XM_054379367.1 → XP_054235342.1  zinc finger protein 263 isoform X8

    5. XM_054379365.1 → XP_054235340.1  zinc finger protein 263 isoform X6

    6. XM_054379366.1 → XP_054235341.1  zinc finger protein 263 isoform X7

      UniProtKB/TrEMBL
      I3NI39

    7. XM_054379368.1 → XP_054235343.1  zinc finger protein 263 isoform X9

    8. XM_054379361.1 → XP_054235336.1  zinc finger protein 263 isoform X2

    9. XM_054379364.1 → XP_054235339.1  zinc finger protein 263 isoform X5

    10. XM_054379371.1 → XP_054235346.1  zinc finger protein 263 isoform X11

    11. XM_054379363.1 → XP_054235338.1  zinc finger protein 263 isoform X4

    12. XM_054379369.1 → XP_054235344.1  zinc finger protein 263 isoform X10

    13. XM_054379370.1 → XP_054235345.1  zinc finger protein 263 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14978.2 GenPept UniProtKB/Swiss-Prot:O14978

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