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    CBLL2 Cbl proto-oncogene like 2 [ Homo sapiens (human) ]

    Gene ID: 158506, updated on 9-Dec-2024

    Summary

    Official Symbol
    CBLL2provided by HGNC
    Official Full Name
    Cbl proto-oncogene like 2provided by HGNC
    Primary source
    HGNC:HGNC:26371
    See related
    Ensembl:ENSG00000175809 AllianceGenome:HGNC:26371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT138; HAKAIL; ZNF645
    Summary
    This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein localization suggests a role in human sperm production and quality control. [provided by RefSeq, Aug 2011]
    Orthologs
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    Genomic context

    See CBLL2 in Genome Data Viewer
    Location:
    Xp22.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (22272913..22274461)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (21856311..21857859)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (22291030..22292578)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29487 Neighboring gene spermine synthase Neighboring gene phosphate regulating endopeptidase X-linked Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29488 Neighboring gene PHEX antisense RNA 1 Neighboring gene PTCHD1 antisense RNA (head to head) Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:22383141-22384340 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:22417737-22418936 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:22450970-22452169 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:22463802-22464451 Neighboring gene methyltransferase like 15 pseudogene 3 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:22544316-22545515 Neighboring gene RNA, U6 small nuclear 266, pseudogene

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25735

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase CBLL2
    Names
    E3 ubiquitin ligase
    E3 ubiquitin-protein ligase ZNF645
    RING-type E3 ubiquitin transferase ZNF645
    c-Cbl-like protein 2
    cbl proto-oncogene-like protein 2
    zinc finger protein 645
    NP_689790.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021438.1 RefSeqGene

      Range
      4971..6519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_152577.4NP_689790.1  E3 ubiquitin-protein ligase CBLL2

      See identical proteins and their annotated locations for NP_689790.1

      Status: REVIEWED

      Source sequence(s)
      BX293560
      Consensus CDS
      CCDS14205.1
      UniProtKB/Swiss-Prot
      A0AV29, A0AV31, E3SBK4, Q6DJY9, Q8N7E2
      Related
      ENSP00000323348.2, ENST00000323684.4
      Conserved Domains (1) summary
      cd00162
      Location:57100
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      22272913..22274461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      21856311..21857859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)