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    TMX4 thioredoxin related transmembrane protein 4 [ Homo sapiens (human) ]

    Gene ID: 56255, updated on 10-Dec-2024

    Summary

    Official Symbol
    TMX4provided by HGNC
    Official Full Name
    thioredoxin related transmembrane protein 4provided by HGNC
    Primary source
    HGNC:HGNC:25237
    See related
    Ensembl:ENSG00000125827 MIM:616766; AllianceGenome:HGNC:25237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDIA14; TXNDC13; DJ971N18.2
    Summary
    This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]
    Expression
    Broad expression in testis (RPKM 50.0), heart (RPKM 24.6) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TMX4 in Genome Data Viewer
    Location:
    20p12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (7977346..8019761, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (8019162..8061561, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (7957993..8000408, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene HSPBAP1 pseudogene 1 Neighboring gene hydroxyacid oxidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17535 Neighboring gene NANOG hESC enhancer GRCh37_chr20:7936767-7937438 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:7964803-7965420 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12667 Neighboring gene TMX4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 13354 Neighboring gene Sharpr-MPRA regulatory region 6433 Neighboring gene phosphorylase kinase regulatory subunit beta pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TMX4; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1162

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    thioredoxin-related transmembrane protein 4
    Names
    protein disulfide isomerase family A, member 14
    thioredoxin domain containing 13
    thioredoxin domain-containing protein 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021156.4NP_066979.2  thioredoxin-related transmembrane protein 4 precursor

      See identical proteins and their annotated locations for NP_066979.2

      Status: VALIDATED

      Source sequence(s)
      AL021396, BC021964, BC044777, HY011753
      Consensus CDS
      CCDS13101.1
      UniProtKB/Swiss-Prot
      Q8N4P7, Q8NCC1, Q9H1E5, Q9UJA1, Q9ULQ8
      Related
      ENSP00000246024.2, ENST00000246024.7
      Conserved Domains (1) summary
      cd02994
      Location:37137
      PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      7977346..8019761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      8019162..8061561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)