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    SLC35G2 solute carrier family 35 member G2 [ Homo sapiens (human) ]

    Gene ID: 80723, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC35G2provided by HGNC
    Official Full Name
    solute carrier family 35 member G2provided by HGNC
    Primary source
    HGNC:HGNC:28480
    See related
    Ensembl:ENSG00000168917 MIM:617812; AllianceGenome:HGNC:28480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM22
    Summary
    Located in Golgi apparatus; plasma membrane; and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal (RPKM 2.6), testis (RPKM 2.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Try the new Transcript table

    Genomic context

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    See SLC35G2 in Genome Data Viewer
    Location:
    3q22.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (136819126..136855888)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (139559143..139596547)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136537968..136574730)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr3:136470665-136471596 and GRCh37_chr3:136471597-136472528 Neighboring gene STAG1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14760 Neighboring gene sulfotransferase family 1D member 1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14761 Neighboring gene NCK1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136587915-136588414 Neighboring gene NCK adaptor protein 1 Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene MPRA-validated peak4840 silencer Neighboring gene IL20RB antisense RNA 1 Neighboring gene interleukin 20 receptor subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. Dobashi S, et al. Oncol Rep, 2009 Feb. PMID 19148500
    2. Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. Qian C, et al. Elife, 2021 Jul 16. PMID 34269178, Free PMC Article
    3. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature, 2014 Jul 24. PMID 25056061, Free PMC Article
    4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
    5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    2. the TMEM22/RAB37 complex is likely to play a crucial role in growth of renal cell carcinoma
      Title: Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3295, DKFZp564K2464

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 35 member G2
    Names
    transmembrane protein 22

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097599.2 → NP_001091068.1  solute carrier family 35 member G2

      See identical proteins and their annotated locations for NP_001091068.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC050423, BI962644, CB123281
      Consensus CDS
      CCDS3091.1
      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
      Conserved Domains (2) summary
      COG0697
      Location:102 → 389
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:256 → 388
      EamA; EamA-like transporter family

    2. NM_001097600.2 → NP_001091069.1  solute carrier family 35 member G2

      See identical proteins and their annotated locations for NP_001091069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC000111, BC050423, CB123281
      Consensus CDS
      CCDS3091.1
      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
      Related
      ENSP00000376794.3, ENST00000393079.3
      Conserved Domains (2) summary
      COG0697
      Location:102 → 389
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:256 → 388
      EamA; EamA-like transporter family

    3. NM_025246.3 → NP_079522.2  solute carrier family 35 member G2

      See identical proteins and their annotated locations for NP_079522.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC050423, CB123281
      Consensus CDS
      CCDS3091.1
      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
      Related
      ENSP00000400839.2, ENST00000446465.3
      Conserved Domains (2) summary
      COG0697
      Location:102 → 389
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:256 → 388
      EamA; EamA-like transporter family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      136819126..136855888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007290.2 → XP_016862779.1  solute carrier family 35 member G2 isoform X1

      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
      Conserved Domains (2) summary
      COG0697
      Location:102 → 389
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:256 → 388
      EamA; EamA-like transporter family

    2. XM_011513214.3 → XP_011511516.1  solute carrier family 35 member G2 isoform X1

      See identical proteins and their annotated locations for XP_011511516.1

      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
      Conserved Domains (2) summary
      COG0697
      Location:102 → 389
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:256 → 388
      EamA; EamA-like transporter family

    3. XM_017007289.2 → XP_016862778.1  solute carrier family 35 member G2 isoform X1

      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
      Conserved Domains (2) summary
      COG0697
      Location:102 → 389
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:256 → 388
      EamA; EamA-like transporter family

    4. XM_017007291.2 → XP_016862780.1  solute carrier family 35 member G2 isoform X1

      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
      Conserved Domains (2) summary
      COG0697
      Location:102 → 389
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:256 → 388
      EamA; EamA-like transporter family

    5. XM_006713773.5 → XP_006713836.1  solute carrier family 35 member G2 isoform X1

      See identical proteins and their annotated locations for XP_006713836.1

      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
      Conserved Domains (2) summary
      COG0697
      Location:102 → 389
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:256 → 388
      EamA; EamA-like transporter family

    6. XM_047449027.1 → XP_047304983.1  solute carrier family 35 member G2 isoform X1

      UniProtKB/Swiss-Prot
      B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      139559143..139596547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348027.1 → XP_054204002.1  solute carrier family 35 member G2 isoform X1

    2. XM_054348028.1 → XP_054204003.1  solute carrier family 35 member G2 isoform X1

    3. XM_054348026.1 → XP_054204001.1  solute carrier family 35 member G2 isoform X1

    4. XM_054348029.1 → XP_054204004.1  solute carrier family 35 member G2 isoform X1

    5. XM_054348024.1 → XP_054203999.1  solute carrier family 35 member G2 isoform X1

    6. XM_054348025.1 → XP_054204000.1  solute carrier family 35 member G2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TBE7.3 GenPept UniProtKB/Swiss-Prot:Q8TBE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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