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    YES1 YES proto-oncogene 1, Src family tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 7525, updated on 27-Nov-2024

    Summary

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    Official Symbol
    YES1provided by HGNC
    Official Full Name
    YES proto-oncogene 1, Src family tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:12841
    See related
    Ensembl:ENSG00000176105 MIM:164880; AllianceGenome:HGNC:12841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Yes; c-yes; HsT441; P61-YES
    Summary
    This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See YES1 in Genome Data Viewer
    Location:
    18p11.32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (721588..812753, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (875925..969846, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (721588..812243, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene clusterin like 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:657377-657878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:657879-658378 Neighboring gene TYMS opposite strand RNA Neighboring gene enolase superfamily member 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:686134-686722 Neighboring gene thymidylate synthetase Neighboring gene ReSE screen-validated silencer GRCh37_chr18:697612-697744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:712826-713405 Neighboring gene Sharpr-MPRA regulatory region 6782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13022 Neighboring gene RNA, U1 small nuclear 109, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9244 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:812361-812903 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:812904-813445 Neighboring gene NANOG hESC enhancer GRCh37_chr18:830325-830891 Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma. Wan X, et al. Neoplasia, 2015 Apr. PMID 25925378, Free PMC Article
    2. Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non-small-cell lung carcinoma. Kim JM, et al. Hum Pathol, 2011 Mar. PMID 21190720
    3. Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. Hamamura K, et al. J Biol Chem, 2011 May 27. PMID 21454696, Free PMC Article
    4. Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer. Zhou Y, et al. Histol Histopathol, 2020 Jul. PMID 31970720
    5. Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. Barraclough J, et al. Neoplasia, 2007 Sep. PMID 17898870, Free PMC Article

    See all (232) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis.
      Title: Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis.
    2. YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.
      Title: YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.
    3. YES1 Is a Druggable Oncogenic Target in SCLC.
      Title: YES1 Is a Druggable Oncogenic Target in SCLC.
    4. Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma.
      Title: Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma.
    5. EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis.
      Title: EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis.
    6. Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation.
      Title: Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation.
    7. Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer.
      Title: Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer.
    8. MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells.
      Title: MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells.
    9. Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies.
      Title: Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies.
    10. YES1 is essential for NSCLC carcinogenesis. YES1 overexpression induced metastatic spread in preclinical in vivo models. YES1 genetic depletion by CRISPR/Cas9 technology significantly reduced tumor growth and metastasis.
      Title: YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
    		  
    involved_in T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to platelet-derived growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of inflammatory response to antigenic stimulus TAS
    Traceable Author Statement
    more info
    		  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of D-glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of vascular permeability TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase Yes
    Names
    YES1 proto-oncogene, Src family tyrosine kinase
    Yamaguchi sarcoma oncogene
    cellular yes-1 protein
    proto-oncogene c-Yes
    proto-oncogene tyrosine-protein kinase YES
    v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
    NP_005424.1
    XP_005258196.1
    XP_016881449.1
    XP_024307011.1
    XP_024307012.1
    XP_024307013.1
    XP_024307014.1
    XP_024307015.1
    XP_047293726.1
    XP_047293727.1
    XP_054175018.1
    XP_054175019.1
    XP_054175020.1
    XP_054175021.1
    XP_054175022.1
    XP_054175023.1
    XP_054175024.1
    XP_054175025.1
    XP_054175026.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005433.4 → NP_005424.1  tyrosine-protein kinase Yes

      See identical proteins and their annotated locations for NP_005424.1

      Status: REVIEWED

      Source sequence(s)
      AP000894, AP001020, AP001178
      Consensus CDS
      CCDS11824.1
      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947
      UniProtKB/TrEMBL
      B2RA70
      Related
      ENSP00000324740.4, ENST00000314574.5
      Conserved Domains (3) summary
      cd09933
      Location:154 → 253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94 → 151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264 → 542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      721588..812753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437770.1 → XP_047293726.1  tyrosine-protein kinase Yes isoform X2

    2. XM_024451244.2 → XP_024307012.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947
      UniProtKB/TrEMBL
      B2RA70
      Conserved Domains (3) summary
      cd09933
      Location:154 → 253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94 → 151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264 → 542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

    3. XM_047437771.1 → XP_047293727.1  tyrosine-protein kinase Yes isoform X2

    4. XM_024451246.2 → XP_024307014.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947
      UniProtKB/TrEMBL
      B2RA70
      Conserved Domains (3) summary
      cd09933
      Location:154 → 253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94 → 151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264 → 542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

    5. XM_024451247.2 → XP_024307015.1  tyrosine-protein kinase Yes isoform X2

      UniProtKB/TrEMBL
      B2RA70
      Conserved Domains (3) summary
      cd09933
      Location:154 → 253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94 → 151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cl21453
      Location:264 → 498
      PKc_like; Protein Kinases, catalytic domain

    6. XM_024451243.2 → XP_024307011.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947
      UniProtKB/TrEMBL
      B2RA70
      Related
      ENSP00000462468.1, ENST00000584307.5
      Conserved Domains (3) summary
      cd09933
      Location:154 → 253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94 → 151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264 → 542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

    7. XM_005258139.5 → XP_005258196.1  tyrosine-protein kinase Yes isoform X2

      See identical proteins and their annotated locations for XP_005258196.1

      UniProtKB/TrEMBL
      B2RA70
      Conserved Domains (3) summary
      cd09933
      Location:154 → 253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94 → 151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cl21453
      Location:264 → 498
      PKc_like; Protein Kinases, catalytic domain

    8. XM_017025960.3 → XP_016881449.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947
      UniProtKB/TrEMBL
      B2RA70
      Conserved Domains (3) summary
      cd09933
      Location:154 → 253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94 → 151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264 → 542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

    9. XM_024451245.2 → XP_024307013.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947
      UniProtKB/TrEMBL
      B2RA70
      Related
      ENSP00000464380.1, ENST00000577961.5
      Conserved Domains (3) summary
      cd09933
      Location:154 → 253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94 → 151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264 → 542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      875925..969846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319050.1 → XP_054175025.1  tyrosine-protein kinase Yes isoform X2

    2. XM_054319044.1 → XP_054175019.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947

    3. XM_054319045.1 → XP_054175020.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947

    4. XM_054319049.1 → XP_054175024.1  tyrosine-protein kinase Yes isoform X2

    5. XM_054319043.1 → XP_054175018.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947

    6. XM_054319051.1 → XP_054175026.1  tyrosine-protein kinase Yes isoform X2

    7. XM_054319048.1 → XP_054175023.1  tyrosine-protein kinase Yes isoform X2

    8. XM_054319046.1 → XP_054175021.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947

    9. XM_054319047.1 → XP_054175022.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      A6NLB3, D3DUH1, P07947
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07947.3 GenPept UniProtKB/Swiss-Prot:P07947

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