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    GPRC5A G protein-coupled receptor class C group 5 member A [ Homo sapiens (human) ]

    Gene ID: 9052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPRC5Aprovided by HGNC
    Official Full Name
    G protein-coupled receptor class C group 5 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:9836
    See related
    Ensembl:ENSG00000013588 MIM:604138; AllianceGenome:HGNC:9836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAI3; TIG1; RAIG1; GPCR5A; PEIG-1
    Summary
    This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lung (RPKM 125.2), colon (RPKM 33.4) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPRC5A in Genome Data Viewer
    Location:
    12p13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12891562..12917937)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12765164..12791546)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13044496..13070871)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902881 Neighboring gene RPL13AP20-GPRC5A intergenic CAGE-defined mid-level expression enhancer Neighboring gene ribosomal protein L13a pseudogene 20 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13058787 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13059781 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13073965 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13075202 Neighboring gene microRNA 614 Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene G protein-coupled receptor class C group 5 member D Neighboring gene small nucleolar RNA SNORD88

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPRC5A overexpression predicted advanced biological behaviors and poor prognosis in patients with gastric cancer. Liu H, et al. Tumour Biol, 2016 Jan. PMID 26227221
    2. RAI3 knockdown enhances osteogenic differentiation of bone marrow mesenchymal stem cells via STAT3 signaling pathway. Jin C, et al. Biochem Biophys Res Commun, 2020 Apr 2. PMID 32014253
    3. Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer. Moyano-Galceran L, et al. EMBO Mol Med, 2020 Apr 7. PMID 32115889, Free PMC Article
    4. GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer. Sawada Y, et al. Int J Cancer, 2020 Mar 1. PMID 31276604
    5. Gprc5a depletion enhances the risk of smoking-induced lung tumorigenesis and mortality. Guo W, et al. Biomed Pharmacother, 2019 Jun. PMID 30901718

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway.
      Title: GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway.
    2. GPRC5A promotes paclitaxel resistance and glucose content in NSCLC.
      Title: GPRC5A promotes paclitaxel resistance and glucose content in NSCLC.
    3. Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
      Title: Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
    4. [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts].
      Title: [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts].
    5. Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease.
      Title: Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease.
    6. The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity.
      Title: The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity.
    7. RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer.
      Title: RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer.
    8. Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma.
      Title: Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma.
    9. Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis.
      Title: Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis.
    10. GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background.
      Title: GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular exosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retinoic acid-induced protein 3
    Names
    G-protein coupled receptor family C group 5 member A
    TPA induced gene 1
    orphan G-protein-coupling receptor PEIG-1
    phorbol ester induced gene 1
    phorbol ester induced protein-1
    retinoic acid induced 3
    retinoic acid responsive
    retinoic acid-induced gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003979.4 → NP_003970.1  retinoic acid-induced protein 3

      See identical proteins and their annotated locations for NP_003970.1

      Status: REVIEWED

      Source sequence(s)
      AC007688, AF095448, AI587426, AK122672
      Consensus CDS
      CCDS8657.1
      UniProtKB/Swiss-Prot
      B3KV45, O95357, Q8NFJ5
      UniProtKB/TrEMBL
      A8K556
      Related
      ENSP00000014914.6, ENST00000014914.6
      Conserved Domains (1) summary
      cd15279
      Location:26 → 270
      7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      12891562..12917937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      12765164..12791546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NFJ5.2 GenPept UniProtKB/Swiss-Prot:Q8NFJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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