GBP7 guanylate binding protein 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GBP7provided by HGNC
Official Full Name: guanylate binding protein 7provided by HGNC
Primary source: HGNC:HGNC:29606
See related: Ensembl:ENSG00000213512 MIM:612468; AllianceGenome:HGNC:29606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GBP4L
Summary: Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]
Expression: Biased expression in liver (RPKM 25.8) and lung (RPKM 0.3) See more
Orthologs: all
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Genomic context

Location:: 1p22.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (89131742..89176003, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (88975111..89019382, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (89597425..89641686, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-kappaB and JAK-STAT Signaling Pathways.
Title: Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways.
Observational study of gene-disease association. (HuGE Navigator)
Title: Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3150 (e-PCR)
- UniSTS:60762

AL010053 (e-PCR)
- UniSTS:1250

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytolysis in another organism	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to protozoan	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to protozoan	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type III interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanylate-binding protein 7

Names: GBP-7; GTP-binding protein 7; guanine nucleotide-binding protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207398.3 → NP_997281.2 guanylate-binding protein 7

See identical proteins and their annotated locations for NP_997281.2

Status: VALIDATED

Source sequence(s)

AC104459, AK096141

Consensus CDS

CCDS720.1

UniProtKB/Swiss-Prot

Q8N8V2

Related

ENSP00000294671.2, ENST00000294671.3

Conserved Domains (3) summary

pfam02841
Location:283 → 579

GBP_C; Guanylate-binding protein, C-terminal domain

pfam02263
Location:18 → 281

GBP; Guanylate-binding protein, N-terminal domain

cd16269
Location:289 → 579

GBP_C; Guanylate-binding protein, C-terminal domain