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    FIRRM FIGNL1 interacting regulator of recombination and mitosis [ Homo sapiens (human) ]

    Gene ID: 55732, updated on 3-Dec-2024

    Summary

    Official Symbol
    FIRRMprovided by HGNC
    Official Full Name
    FIGNL1 interacting regulator of recombination and mitosisprovided by HGNC
    Primary source
    HGNC:HGNC:25565
    See related
    Ensembl:ENSG00000000460 AllianceGenome:HGNC:25565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLIP; Apolo1; MEICA1; C1orf112
    Summary
    Enables protein kinase binding activity. Involved in several processes, including chromosome segregation; interstrand cross-link repair; and regulation of protein kinase activity. Located in several cellular components, including kinetochore; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 5.7), lymph node (RPKM 3.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FIRRM in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169783837..169854080)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169139615..169209809)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169763871..169823221)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selectin E Neighboring gene uncharacterized LOC101928628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169751147-169751648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2079 Neighboring gene methyltransferase 18, RPL3 N3(tau)-histidine Neighboring gene MPRA-validated peak450 silencer Neighboring gene RNA, 7SL, cytoplasmic 333, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2080 Neighboring gene SCY1 like pseudokinase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169862205-169862792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169862793-169863380 Neighboring gene VISTA enhancer hs1442 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:169914181-169914349 Neighboring gene kinesin associated protein 3 Neighboring gene RNA, 7SL, cytoplasmic 269, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10706, FLJ13470, MGC130018, MGC130019

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    FIGNL1-interacting regulator of recombination and mitosis
    Names
    Fidgetin-like-1 interacting protein
    POLO1-associating protein
    associating protein with POLO1
    uncharacterized protein C1orf112

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320047.2NP_001306976.1  FIGNL1-interacting regulator of recombination and mitosis isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL031297, BC091516, DA770714, DC401980
      Consensus CDS
      CCDS1285.1
      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
      Related
      ENSP00000352276.4, ENST00000359326.9
      Conserved Domains (1) summary
      pfam14868
      Location:176728
      DUF4487; Domain of unknown function (DUF4487)
    2. NM_001320048.2NP_001306977.1  FIGNL1-interacting regulator of recombination and mitosis isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK001568, AK303296, AL031297, BC091516
      UniProtKB/TrEMBL
      B4DGF2
      Conserved Domains (1) summary
      pfam14868
      Location:41593
      DUF4487; Domain of unknown function (DUF4487)
    3. NM_001320050.2NP_001306979.1  FIGNL1-interacting regulator of recombination and mitosis isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK096493, BC011012, BC011445, CB159947, DC401980
      Consensus CDS
      CCDS81400.1
      UniProtKB/TrEMBL
      A0A1B0GV14
      Related
      ENSP00000490333.1, ENST00000496973.5
    4. NM_001320051.2NP_001306980.1  FIGNL1-interacting regulator of recombination and mitosis isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL354614, BC011445, BC091516, CB159947
      Consensus CDS
      CCDS81401.1
      UniProtKB/TrEMBL
      A0A1B0GUP7
      Related
      ENSP00000490194.1, ENST00000472795.5
    5. NM_001363739.2NP_001350668.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Consensus CDS
      CCDS86030.1
      Conserved Domains (1) summary
      pfam14868
      Location:1405
      DUF4487; Domain of unknown function (DUF4487)
    6. NM_001366768.1NP_001353697.1  FIGNL1-interacting regulator of recombination and mitosis isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      UniProtKB/TrEMBL
      B4DGF2
    7. NM_001366769.1NP_001353698.1  FIGNL1-interacting regulator of recombination and mitosis isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      UniProtKB/TrEMBL
      B4DGF2
      Conserved Domains (1) summary
      pfam14868
      Location:234786
      DUF4487; Domain of unknown function (DUF4487)
    8. NM_001366770.1NP_001353699.1  FIGNL1-interacting regulator of recombination and mitosis isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      UniProtKB/TrEMBL
      B4DGF2
    9. NM_001366771.1NP_001353700.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Consensus CDS
      CCDS86030.1
      Conserved Domains (1) summary
      pfam14868
      Location:1405
      DUF4487; Domain of unknown function (DUF4487)
    10. NM_001366772.1NP_001353701.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Consensus CDS
      CCDS86030.1
      Related
      ENSP00000389257.3, ENST00000413811.3
      Conserved Domains (1) summary
      pfam14868
      Location:1405
      DUF4487; Domain of unknown function (DUF4487)
    11. NM_001366773.1NP_001353702.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Consensus CDS
      CCDS86030.1
      Conserved Domains (1) summary
      pfam14868
      Location:1405
      DUF4487; Domain of unknown function (DUF4487)

    RNA

    1. NR_159440.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Related
      ENST00000459772.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      169783837..169854080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424760.1XP_047280716.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    2. XM_047424762.1XP_047280718.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    3. XM_047424751.1XP_047280707.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    4. XM_047424770.1XP_047280726.1  FIGNL1-interacting regulator of recombination and mitosis isoform X3

      UniProtKB/TrEMBL
      B4DGF2
    5. XM_047424752.1XP_047280708.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    6. XM_047424743.1XP_047280699.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
      Related
      ENSP00000286031.6, ENST00000286031.10
    7. XM_047424759.1XP_047280715.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    8. XM_017001723.2XP_016857212.1  FIGNL1-interacting regulator of recombination and mitosis isoform X2

      UniProtKB/TrEMBL
      B4DGF2
    9. XM_047424771.1XP_047280727.1  FIGNL1-interacting regulator of recombination and mitosis isoform X4

    RNA

    1. XR_921872.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      169139615..169209809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337570.1XP_054193545.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    2. XM_054337571.1XP_054193546.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    3. XM_054337567.1XP_054193542.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    4. XM_054337568.1XP_054193543.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    5. XM_054337573.1XP_054193548.1  FIGNL1-interacting regulator of recombination and mitosis isoform X3

      UniProtKB/TrEMBL
      B4DGF2
    6. XM_054337569.1XP_054193544.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
    7. XM_054337572.1XP_054193547.1  FIGNL1-interacting regulator of recombination and mitosis isoform X2

      UniProtKB/TrEMBL
      B4DGF2
    8. XM_054337574.1XP_054193549.1  FIGNL1-interacting regulator of recombination and mitosis isoform X4

    RNA

    1. XR_008486103.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018186.3: Suppressed sequence

      Description
      NM_018186.3: This RefSeq has been removed because currently there is insufficient support for the transcript.