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    HILPDA hypoxia inducible lipid droplet associated [ Homo sapiens (human) ]

    Gene ID: 29923, updated on 9-Dec-2024

    Summary

    Official Symbol
    HILPDAprovided by HGNC
    Official Full Name
    hypoxia inducible lipid droplet associatedprovided by HGNC
    Primary source
    HGNC:HGNC:28859
    See related
    Ensembl:ENSG00000135245 MIM:617905; AllianceGenome:HGNC:28859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIG2; HIG-2; C7orf68
    Summary
    Enables signaling receptor binding activity. Involved in several processes, including autocrine signaling; cellular response to hypoxia; and positive regulation of lipid storage. Located in several cellular components, including cell surface; lipid droplet; and secretory granule. Implicated in colorectal cancer and hepatocellular carcinoma. Biomarker of colorectal cancer and hepatocellular carcinoma. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in esophagus (RPKM 37.4), fat (RPKM 20.9) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HILPDA in Genome Data Viewer
    Location:
    7q32.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (128455878..128458418)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (129767662..129770201)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128095932..128098472)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37 pseudogene 16 Neighboring gene RNA, U7 small nuclear 54 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:128093960-128094666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18608 Neighboring gene Sharpr-MPRA regulatory region 9446 Neighboring gene EFCAB3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26601 Neighboring gene methyltransferase 2B, tRNA N3-cytidine Neighboring gene MPRA-validated peak6715 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18610 Neighboring gene ribosomal protein S10 pseudogene 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of hypoxia inducible lipid droplet-associated protein (HILPDA) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21076, MGC138388

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hypoxia-inducible lipid droplet-associated protein
    Names
    hypoxia inducible gene 2
    hypoxia-inducible gene 2 protein
    hypoxia-inducible protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098786.2NP_001092256.1  hypoxia-inducible lipid droplet-associated protein

      See identical proteins and their annotated locations for NP_001092256.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF144755, AL691669, BC008573, CX784347
      Consensus CDS
      CCDS5802.1
      UniProtKB/Swiss-Prot
      A4D0Z5, Q52LY5, Q53HJ7, Q9Y5L2
      Related
      ENSP00000388871.2, ENST00000435296.2
      Conserved Domains (1) summary
      pfam15220
      Location:163
      HILPDA; Hypoxia-inducible lipid droplet-associated
    2. NM_013332.4NP_037464.1  hypoxia-inducible lipid droplet-associated protein

      See identical proteins and their annotated locations for NP_037464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF144755, BC001863, BC008573, CD686848
      Consensus CDS
      CCDS5802.1
      UniProtKB/Swiss-Prot
      A4D0Z5, Q52LY5, Q53HJ7, Q9Y5L2
      Related
      ENSP00000257696.4, ENST00000257696.5
      Conserved Domains (1) summary
      pfam15220
      Location:163
      HILPDA; Hypoxia-inducible lipid droplet-associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      128455878..128458418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      129767662..129770201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)