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    DCAF1 DDB1 and CUL4 associated factor 1 [ Homo sapiens (human) ]

    Gene ID: 9730, updated on 27-Nov-2024

    Summary

    Official Symbol
    DCAF1provided by HGNC
    Official Full Name
    DDB1 and CUL4 associated factor 1provided by HGNC
    Primary source
    HGNC:HGNC:30911
    See related
    Ensembl:ENSG00000145041 MIM:617259; AllianceGenome:HGNC:30911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIP; VPRBP
    Summary
    Enables histone H2AT120 kinase activity; nuclear estrogen receptor binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including cell competition in a multicellular organism; negative regulation of transcription by RNA polymerase II; and positive regulation of protein catabolic process. Located in COP9 signalosome; fibrillar center; and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in centrosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 27.5), thyroid (RPKM 8.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DCAF1 in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51395867..51505639, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51426284..51536063, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51433298..51534031, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 3 Neighboring gene NANOG hESC enhancer GRCh37_chr3:50928312-50928861 Neighboring gene Sharpr-MPRA regulatory region 894 Neighboring gene ST13, Hsp70 interacting protein pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14407 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:51263456-51264655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51377300-51378184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51430225-51430730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51430731-51431238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14412 Neighboring gene RNA binding motif protein 15B Neighboring gene mesencephalic astrocyte derived neurotrophic factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14414 Neighboring gene uncharacterized LOC105377085 Neighboring gene Sharpr-MPRA regulatory region 10823 Neighboring gene Sharpr-MPRA regulatory region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19920 Neighboring gene NANOG hESC enhancer GRCh37_chr3:51578193-51578834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51581873-51582372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51589128-51590066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51617110-51617895 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:51627487-51627690 Neighboring gene RAD54 like 2 Neighboring gene RNA, U6atac small nuclear 29, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 Vpr downregulates HLTF in a DCAF1-dependent manner in HeLa, Jurkat T and primary T cells and primary macrophages as shown through DCAF1 siRNA knockdown PubMed
    Knockdown of Vpr (HIV-1) binding protein (VPRBP) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Env-dependent MDM/T cell viral synapse formation is facilitated by Vpr/VPRBP (DCAF1) cooperation PubMed
    env VPRBP (DCAF1) is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells PubMed
    Envelope surface glycoprotein gp160, precursor env DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells PubMed
    Envelope transmembrane glycoprotein gp41 env Env-dependent MDM/T cell viral synapse formation is facilitated by Vpr/VPRBP (DCAF1) cooperation PubMed
    env VPRBP (DCAF1) is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells PubMed
    Pr55(Gag) gag DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells PubMed
    Vpr vpr Vpr-dependent HIV-1 spread from MDMs to CD4+ T lymphocytes requires VPRBP (DCAF1) PubMed
    vpr Vpr cooperates with VPRBP (DCAF1) to increase T lymphocyte HIV-1 infection by counteracting type I interferon inducible restriction of Env-dependent viral synapse formation between MDM and T cells PubMed
    vpr HIV-1 Vpr binds DCAF1; Vpr E25,L26 and a2 E29 form a small pocket for DCAF1 W1156 binding (the N-terminal tail of Vpr wraps around the propeller, following small groove between two blades) PubMed
    vpr HIV-1 Vpr binds DCAF1; residues R62, Q65 and R73 on a3 of Vpr form hydrogen bonds with E1088, S1136 and T1139 of DCAF1, respectively. Vpr F69 inserts in a small hydrophobic pocket formed by DCAF1 A1137, F1330 and F1355 PubMed
    vpr DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env gp160 (gp120/gp41) expression in MDM cells PubMed
    vpr Residues N1135 and W1156 in DCAF1 are required for its binding to the SIVmac Vpx Q76 residue but not with HIV-1 Vpr PubMed
    vpr The minimal domain (residues 1041-1393) of DCAF1, which contains the motifs required for proper recruitment of both Vpr and DDB1, is not sufficient to support Vpr-mediated G2 arrest activity PubMed
    vpr The two WD-40 motifs (residues 1041-1393) in the C-terminal region of DCAF1 form a complex with HIV-1 Vpr and DDB1. The double mutant DCAF1 R1247/1283A completely abolishes its ability to bind both Vpr and DDB1 PubMed
    vpr The interaction of HIV-1 Vpr with the EDVP E3 ligase complex (EDD, DDB1, and VPRBP) promotes Vpr-mediated downregulation of TERT protein PubMed
    vpr HIV-1 Vpr directly interacts with the C-terminal SLX1 binding domain of SLX4 and recruits VPRBP to the SSE regulator complex SLX4 PubMed
    vpr Co-immunoprecipitation and glycerol-gradient sedimentation demonstrate that HIV-1 Vpr, VPRBP, DDB1, SLX4, MUS81, EME1, ERCC1, and ERCC4 form a complex PubMed
    vpr HIV-1 Vpr-mediated UNG2 degradation and constitutive UNG2 turnover are dependent on DCAF1 or DDB1 but not on CUL4a or CUL4B in the cullin4 (CUL4)-containing ubiquitin ligase complex in HEK293T cells PubMed
    vpr HIV-1 Vpr complexes with DCAF1, DDB1, CUL4A, CUL4B, and UNG2 proteins in the cullin4 (CUL4)-containing ubiquitin ligase complex in HEK293T cells PubMed
    vpr Mutation of Trp18, Gln65, and His71 residues in HIV-1 Vpr abrogates DDB1-DCAF1 binding and Vpr-induced cell cycle arrest PubMed
    vpr VPRBP is required for HIV-1 Vpr-mediated activation of the SLX4 complex and modulation of MUS81 levels. The interaction between Vpr and VPRBP is involved in MUS81 ubiquitination PubMed
    vpr HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex PubMed
    vpr HIV-1 Vpr induces the degradation of ZIP/sZIP through the DCAF1 ubiquitin ligase, while VprQ65R mutant impairs the Vpr-induced degradation of ZIP/sZIP PubMed
    vpr HIV-1 Vpr co-localizes with the Cul4A ubiquitin ligase complex (Cul4A, DCAF1, and DDB1) in the cellular chromatin compartment PubMed
    vpr HIV-1 Vpr induces the degradation of APOBEC3G through VprBP binding and participation of the proteasome, leading to a reduction in APOBEC3G encapsidation into virions PubMed
    vpr The interaction of HIV-1 Vpr with VprBP enhances HIV-1 infection in monocyte-derived dendritic cells PubMed
    vpr HIV-1 Vpr significantly downregulates expression level of MFN2 in the mitochondria via VprBP-DDB1-CUL4A ubiquitin ligase in a proteasome-dependent manner PubMed
    vpr Upregulation of NKG2D ligands is dependent on HIV-1 Vpr-mediated activation of the TAR DNA damage/stress pathway, which requires the recruitment of the Cul4/DDB1/DCAF1 E3 ubiquitin ligase complex PubMed
    vpr W54R/S79A Vpr mutant impairs to interact with UNG2, but is still able to recruit DCAF1. Three G2 arrest-defective Vpr mutants, Q65R, K27M, and S79A, can interact with DCAF1 PubMed
    vpr A highly conserved 18WxxxxFxxFxxxAFxH33 motif of the HIV-1 Vpr binds to DCAF1, leading to Vpr-induced G2 arrest. Vpr mutants L22S/L23S and V30S/V31S impair the ability to induce G2 arrest PubMed
    vpr HIV-1 Vpr binds DCAF1 and activates the DNA damage response in renal tubule epithelial cells, in which gamma H2AX-positive nuclei are abundant compared to the control PubMed
    vpr DCAF1 interacts with DDB1 as well as the Vpr-UNG2 complex, which leads to polyubiquitination of UNG2 via Vpr PubMed
    vpr Recruitment of a catalytically active CRL4A (VPRBP) complex is required to observe HIV-1 Vpr-interacting unknown cellular ubiquitinated proteins. Phosphorylation of H2AX requires Vpr-induced K48 residue polyubiquitination PubMed
    vpr HIV-1 Vpr forms nuclear foci containing VPRBP and partially co-localizes with DNA repair foci components 53BP1 and phosphorylated RPA32 PubMed
    vpr HIV-1 Vpr(Q65R) mutant fails to bind DDB1 and VprBP, and also fails to induce G2 arrest PubMed
    vpr The interaction between Vpr and the Cul4A-DDB1-VprBP complex is required for the induction of G2 arrest PubMed
    vpr HIV-1 Vpr binds a ternary complex composed of DDB1, DDA1, and VprBP, and modulates the interaction between the DDB1-DDA1-VprBP complex and other factors PubMed
    vpr The leucine/isoleucine-rich domain of HIV-1 Vpr (amino acids 60-81) mediates binding of Vpr to the C-terminal half of VprBP (amino acids 636-1507), resulting in the cytoplasmic retention of Vpr PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0800, MGC102804

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H2AT120 kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear estrogen receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul4-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 1
    Names
    HIV-1 Vpr-binding protein
    Vpr (HIV-1) binding protein
    Vpr-binding protein
    protein VPRBP
    serine/threonine-protein kinase VPRBP
    vpr-interacting protein
    NP_001165375.1
    NP_001336097.1
    NP_001336098.1
    NP_001336099.1
    NP_001336100.1
    NP_001374507.1
    NP_001374508.1
    NP_001374509.1
    NP_001374510.1
    NP_001374511.1
    NP_001374512.1
    NP_055518.1
    XP_005276810.1
    XP_005276812.1
    XP_011532575.1
    XP_011532577.1
    XP_016863036.1
    XP_016863038.1
    XP_047305225.1
    XP_047305226.1
    XP_047305227.1
    XP_047305228.1
    XP_047305229.1
    XP_047305230.1
    XP_047305231.1
    XP_047305232.1
    XP_047305233.1
    XP_047305234.1
    XP_047305235.1
    XP_047305236.1
    XP_047305237.1
    XP_047305238.1
    XP_047305239.1
    XP_054204493.1
    XP_054204494.1
    XP_054204495.1
    XP_054204496.1
    XP_054204497.1
    XP_054204498.1
    XP_054204499.1
    XP_054204500.1
    XP_054204501.1
    XP_054204502.1
    XP_054204503.1
    XP_054204504.1
    XP_054204505.1
    XP_054204506.1
    XP_054204507.1
    XP_054204508.1
    XP_054204509.1
    XP_054204510.1
    XP_054204511.1
    XP_054204512.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171904.2NP_001165375.1  DDB1- and CUL4-associated factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001165375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR and uses and alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1. Variants 2 and 12 both encode the same isoform (2).
      Source sequence(s)
      AB018343, AC092037, BC110371, BP222559, CR986856
      Consensus CDS
      CCDS74944.1
      UniProtKB/Swiss-Prot
      Q9Y4B6
      Related
      ENSP00000421724.2, ENST00000504652.5
      Conserved Domains (3) summary
      sd00039
      Location:10961132
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:873952
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10921310
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001349168.2NP_001336097.1  DDB1- and CUL4-associated factor 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3-5, and 8-11 all encode the same isoform (1).
      Source sequence(s)
      AC092037, AC233756
      Consensus CDS
      CCDS74943.1
      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001349169.2NP_001336098.1  DDB1- and CUL4-associated factor 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3-5, and 8-11 all encode the same isoform (1).
      Source sequence(s)
      AC092037, AC233756
      Consensus CDS
      CCDS74943.1
      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_001349170.2NP_001336099.1  DDB1- and CUL4-associated factor 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3-5, and 8-11 all encode the same isoform (1).
      Source sequence(s)
      AC092037, AC233756
      Consensus CDS
      CCDS74943.1
      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. NM_001349171.2NP_001336100.1  DDB1- and CUL4-associated factor 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' and 3' UTR and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1. Variants 6 and 13 both encode the same isoform (3).
      Source sequence(s)
      AC092037, AC233756
      Conserved Domains (3) summary
      sd00039
      Location:10151051
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:792871
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10111229
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. NM_001387578.1NP_001374507.1  DDB1- and CUL4-associated factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC233756
      Consensus CDS
      CCDS74943.1
      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. NM_001387579.1NP_001374508.1  DDB1- and CUL4-associated factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC233756
      Consensus CDS
      CCDS74943.1
      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Related
      ENSP00000506880.1, ENST00000684031.1
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. NM_001387580.1NP_001374509.1  DDB1- and CUL4-associated factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC233756
      Consensus CDS
      CCDS74943.1
      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    9. NM_001387581.1NP_001374510.1  DDB1- and CUL4-associated factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC233756
      Consensus CDS
      CCDS74943.1
      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    10. NM_001387582.1NP_001374511.1  DDB1- and CUL4-associated factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC233756
      Consensus CDS
      CCDS74944.1
      Conserved Domains (3) summary
      sd00039
      Location:10961132
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:873952
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10921310
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    11. NM_001387583.1NP_001374512.1  DDB1- and CUL4-associated factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC233756
      Conserved Domains (3) summary
      sd00039
      Location:10151051
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:792871
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10111229
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    12. NM_014703.3NP_055518.1  DDB1- and CUL4-associated factor 1 isoform 1

      See identical proteins and their annotated locations for NP_055518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3-5, and 8-11 all encode the same isoform (1).
      Source sequence(s)
      AB018343, AC092037, CR986856
      Consensus CDS
      CCDS74943.1
      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_146065.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC092037, AC233756
    2. NR_170668.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092037, AC233756

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      51395867..51505639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449275.1XP_047305231.1  DDB1- and CUL4-associated factor 1 isoform X2

    2. XM_047449269.1XP_047305225.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Related
      ENSP00000393183.2, ENST00000423656.5
    3. XM_047449278.1XP_047305234.1  DDB1- and CUL4-associated factor 1 isoform X2

    4. XM_047449270.1XP_047305226.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    5. XM_047449274.1XP_047305230.1  DDB1- and CUL4-associated factor 1 isoform X2

    6. XM_047449282.1XP_047305238.1  DDB1- and CUL4-associated factor 1 isoform X3

    7. XM_047449277.1XP_047305233.1  DDB1- and CUL4-associated factor 1 isoform X2

    8. XM_047449276.1XP_047305232.1  DDB1- and CUL4-associated factor 1 isoform X2

    9. XM_017007549.3XP_016863038.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    10. XM_047449271.1XP_047305227.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    11. XM_005276755.6XP_005276812.1  DDB1- and CUL4-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_005276812.1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    12. XM_047449273.1XP_047305229.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    13. XM_047449272.1XP_047305228.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    14. XM_017007547.3XP_016863036.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    15. XM_011534275.4XP_011532577.1  DDB1- and CUL4-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011532577.1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    16. XM_011534273.4XP_011532575.1  DDB1- and CUL4-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011532575.1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    17. XM_047449279.1XP_047305235.1  DDB1- and CUL4-associated factor 1 isoform X3

    18. XM_047449280.1XP_047305236.1  DDB1- and CUL4-associated factor 1 isoform X3

    19. XM_047449281.1XP_047305237.1  DDB1- and CUL4-associated factor 1 isoform X3

    20. XM_005276753.6XP_005276810.1  DDB1- and CUL4-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_005276810.1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
      Conserved Domains (3) summary
      sd00039
      Location:10971133
      7WD40; WD40 repeat [structural motif]
      NF033760
      Location:874953
      gliding_GltG; adventurous gliding motility protein GltG
      cl29593
      Location:10931311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    21. XM_047449283.1XP_047305239.1  DDB1- and CUL4-associated factor 1 isoform X4

    RNA

    1. XR_007095776.1 RNA Sequence

    2. XR_007095774.1 RNA Sequence

    3. XR_007095775.1 RNA Sequence

    4. XR_007095773.1 RNA Sequence

    5. XR_007095777.1 RNA Sequence

    6. XR_007095778.1 RNA Sequence

    7. XR_007095772.1 RNA Sequence

    8. XR_001740385.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      51426284..51536063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348529.1XP_054204504.1  DDB1- and CUL4-associated factor 1 isoform X2

    2. XM_054348518.1XP_054204493.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    3. XM_054348532.1XP_054204507.1  DDB1- and CUL4-associated factor 1 isoform X2

    4. XM_054348520.1XP_054204495.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    5. XM_054348528.1XP_054204503.1  DDB1- and CUL4-associated factor 1 isoform X2

    6. XM_054348536.1XP_054204511.1  DDB1- and CUL4-associated factor 1 isoform X3

    7. XM_054348531.1XP_054204506.1  DDB1- and CUL4-associated factor 1 isoform X2

    8. XM_054348530.1XP_054204505.1  DDB1- and CUL4-associated factor 1 isoform X2

    9. XM_054348519.1XP_054204494.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    10. XM_054348521.1XP_054204496.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    11. XM_054348522.1XP_054204497.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    12. XM_054348526.1XP_054204501.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    13. XM_054348524.1XP_054204499.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    14. XM_054348523.1XP_054204498.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    15. XM_054348525.1XP_054204500.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    16. XM_054348533.1XP_054204508.1  DDB1- and CUL4-associated factor 1 isoform X3

    17. XM_054348534.1XP_054204509.1  DDB1- and CUL4-associated factor 1 isoform X3

    18. XM_054348535.1XP_054204510.1  DDB1- and CUL4-associated factor 1 isoform X3

    19. XM_054348527.1XP_054204502.1  DDB1- and CUL4-associated factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
    20. XM_054348537.1XP_054204512.1  DDB1- and CUL4-associated factor 1 isoform X4

    RNA

    1. XR_008486866.1 RNA Sequence

    2. XR_008486864.1 RNA Sequence

    3. XR_008486865.1 RNA Sequence

    4. XR_008486863.1 RNA Sequence

    5. XR_008486867.1 RNA Sequence

    6. XR_008486868.1 RNA Sequence

    7. XR_008486861.1 RNA Sequence

    8. XR_008486862.1 RNA Sequence