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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_052795.1 RefSeqGene
- Range
-
5322..103428
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001007525.5 → NP_001007526.3 NACHT domain- and WD repeat-containing protein 1 isoform 1
See identical proteins and their annotated locations for NP_001007526.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AC008737, AK090685, BC117698, BX489211, CB242932, CR749794
- Consensus CDS
-
CCDS32945.2
- UniProtKB/TrEMBL
-
F8W0U9
- Related
- ENSP00000428579.2, ENST00000524140.7
- Conserved Domains (4) summary
-
- cd00009
Location:314 → 399
- AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
- COG2319
Location:1065 → 1427
- WD40; WD40 repeat [General function prediction only]
- sd00039
Location:871 → 908
- 7WD40; WD40 repeat [structural motif]
- cl25539
Location:860 → 1156
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
-
NM_001290355.3 → NP_001277284.1 NACHT domain- and WD repeat-containing protein 1 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, initiates translation at an alternate start codon and contains an alternate exon in the 3' coding region, resulting in a translational frameshift, compared to variant 1. It encodes isoform 2, which is shorter and has distinct N- and C-termini, compared to isoform 1.
- Source sequence(s)
-
AC008737, AK090685, BC117698, BX648940, CB242932
- UniProtKB/TrEMBL
-
F8W0U9
- Conserved Domains (4) summary
-
- COG2319
Location:771 → 1151
- WD40; WD40 repeat [General function prediction only]
- pfam13191
Location:177 → 225
- AAA_16; AAA ATPase domain
- sd00039
Location:1124 → 1162
- 7WD40; WD40 repeat [structural motif]
- cl02567
Location:725 → 1021
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
-
NM_001347994.1 → NP_001334923.1 NACHT domain- and WD repeat-containing protein 1 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon, and contains an alternate exon in its 3' coding region, resulting in a translational frameshift, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus and distinct C-terminus compared to isoform 1.
- Source sequence(s)
-
AC008737, AK090685, BC117698, CB242932, CR749794
- UniProtKB/TrEMBL
-
F8W0U9
- Related
-
ENST00000673671.1
- Conserved Domains (4) summary
-
- cd00009
Location:108 → 193
- AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
- COG2319
Location:859 → 1282
- WD40; WD40 repeat [General function prediction only]
- sd00039
Location:1053 → 1091
- 7WD40; WD40 repeat [structural motif]
- cl25539
Location:654 → 950
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000019.10 Reference GRCh38.p14 Primary Assembly
- Range
-
16719847..16817963
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011527929.2 → XP_011526231.1 NACHT domain- and WD repeat-containing protein 1 isoform X1
See identical proteins and their annotated locations for XP_011526231.1
- UniProtKB/Swiss-Prot
- C9J021, Q149M9, Q68CT3
- UniProtKB/TrEMBL
-
F8W0U9
- Conserved Domains (5) summary
-
- COG2319
Location:1065 → 1488
- WD40; WD40 repeat [General function prediction only]
- sd00039
Location:1259 → 1297
- 7WD40; WD40 repeat [structural motif]
- cl29593
Location:860 → 1156
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
- cl38936
Location:314 → 399
- P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
- cl40481
Location:336 → 502
- YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
-
XM_024451466.2 → XP_024307234.1 NACHT domain- and WD repeat-containing protein 1 isoform X2
- UniProtKB/TrEMBL
-
F8W0U9
- Related
- ENSP00000501265.1, ENST00000673803.1
- Conserved Domains (4) summary
-
- cd00009
Location:314 → 399
- AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
- COG2319
Location:1065 → 1427
- WD40; WD40 repeat [General function prediction only]
- sd00039
Location:871 → 908
- 7WD40; WD40 repeat [structural motif]
- cl25539
Location:860 → 1156
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
-
XM_011527930.3 → XP_011526232.1 NACHT domain- and WD repeat-containing protein 1 isoform X1
See identical proteins and their annotated locations for XP_011526232.1
- UniProtKB/Swiss-Prot
- C9J021, Q149M9, Q68CT3
- UniProtKB/TrEMBL
-
F8W0U9
- Conserved Domains (5) summary
-
- COG2319
Location:1065 → 1488
- WD40; WD40 repeat [General function prediction only]
- sd00039
Location:1259 → 1297
- 7WD40; WD40 repeat [structural motif]
- cl29593
Location:860 → 1156
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
- cl38936
Location:314 → 399
- P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
- cl40481
Location:336 → 502
- YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
-
XM_011527931.3 → XP_011526233.1 NACHT domain- and WD repeat-containing protein 1 isoform X1
See identical proteins and their annotated locations for XP_011526233.1
- UniProtKB/Swiss-Prot
- C9J021, Q149M9, Q68CT3
- UniProtKB/TrEMBL
-
F8W0U9
- Related
- ENSP00000447224.1, ENST00000552788.1
- Conserved Domains (5) summary
-
- COG2319
Location:1065 → 1488
- WD40; WD40 repeat [General function prediction only]
- sd00039
Location:1259 → 1297
- 7WD40; WD40 repeat [structural motif]
- cl29593
Location:860 → 1156
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
- cl38936
Location:314 → 399
- P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
- cl40481
Location:336 → 502
- YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
-
XM_024451467.2 → XP_024307235.1 NACHT domain- and WD repeat-containing protein 1 isoform X3
- Conserved Domains (3) summary
-
- cd00009
Location:314 → 399
- AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
- sd00039
Location:871 → 908
- 7WD40; WD40 repeat [structural motif]
- cl25539
Location:860 → 1156
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
-
XM_047438676.1 → XP_047294632.1 NACHT domain- and WD repeat-containing protein 1 isoform X5
-
XM_011527934.1 → XP_011526236.1 NACHT domain- and WD repeat-containing protein 1 isoform X4
- Conserved Domains (3) summary
-
- COG2319
Location:468 → 848
- WD40; WD40 repeat [General function prediction only]
- sd00039
Location:821 → 859
- 7WD40; WD40 repeat [structural motif]
- cl02567
Location:422 → 718
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Alternate T2T-CHM13v2.0
Genomic
-
NC_060943.1 Alternate T2T-CHM13v2.0
- Range
-
16854654..16952783
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054320694.1 → XP_054176669.1 NACHT domain- and WD repeat-containing protein 1 isoform X1
- UniProtKB/TrEMBL
-
F8W0U9
-
XM_054320697.1 → XP_054176672.1 NACHT domain- and WD repeat-containing protein 1 isoform X2
- UniProtKB/TrEMBL
-
F8W0U9
-
XM_054320695.1 → XP_054176670.1 NACHT domain- and WD repeat-containing protein 1 isoform X1
- UniProtKB/TrEMBL
-
F8W0U9
-
XM_054320696.1 → XP_054176671.1 NACHT domain- and WD repeat-containing protein 1 isoform X1
- UniProtKB/TrEMBL
-
F8W0U9
-
XM_054320698.1 → XP_054176673.1 NACHT domain- and WD repeat-containing protein 1 isoform X3
-
XM_054320700.1 → XP_054176675.1 NACHT domain- and WD repeat-containing protein 1 isoform X5
-
XM_054320699.1 → XP_054176674.1 NACHT domain- and WD repeat-containing protein 1 isoform X4