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    TMEM38A transmembrane protein 38A [ Homo sapiens (human) ]

    Gene ID: 79041, updated on 9-Dec-2024

    Summary

    Official Symbol
    TMEM38Aprovided by HGNC
    Official Full Name
    transmembrane protein 38Aprovided by HGNC
    Primary source
    HGNC:HGNC:28462
    See related
    Ensembl:ENSG00000072954 MIM:611235; AllianceGenome:HGNC:28462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRICA; TRIC-A
    Summary
    Predicted to enable potassium channel activity. Predicted to be involved in regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including cellular response to caffeine; monoatomic cation transmembrane transport; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in brain (RPKM 7.4), stomach (RPKM 6.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM38A in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (16661139..16690023)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (16795931..16824815)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16771950..16800834)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372296 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16739143-16740074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16748865-16749364 Neighboring gene uncharacterized LOC124904647 Neighboring gene small integral membrane protein 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16772303-16773111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16790368-16790868 Neighboring gene NACHT and WD repeat domain containing 1 Neighboring gene uncharacterized LOC124904648 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:16928291-16928487 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:16936141-16936818 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16939935-16940436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14248 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16947461-16947962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16957115-16957616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16957617-16958116 Neighboring gene SIN3 transcription regulator family member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14249

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3169

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables potassium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in sarcoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sarcoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    trimeric intracellular cation channel type A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024074.4NP_076979.1  trimeric intracellular cation channel type A

      See identical proteins and their annotated locations for NP_076979.1

      Status: VALIDATED

      Source sequence(s)
      AC008737, AC024075
      Consensus CDS
      CCDS12349.1
      UniProtKB/Swiss-Prot
      A8K9P9, Q9H6F2
      Related
      ENSP00000187762.1, ENST00000187762.7
      Conserved Domains (1) summary
      pfam05197
      Location:43225
      TRIC; TRIC channel

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      16661139..16690023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      16795931..16824815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)