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    DDX24 DEAD-box helicase 24 [ Homo sapiens (human) ]

    Gene ID: 57062, updated on 9-Dec-2024

    Summary

    Official Symbol
    DDX24provided by HGNC
    Official Full Name
    DEAD-box helicase 24provided by HGNC
    Primary source
    HGNC:HGNC:13266
    See related
    Ensembl:ENSG00000089737 MIM:606181; AllianceGenome:HGNC:13266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 90.5), adrenal (RPKM 75.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DDX24 in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94048287..94081202, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88275602..88308519, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94514633..94547548, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984663 Neighboring gene uncharacterized LOC124903368 Neighboring gene coiled-coil domain containing 197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94482885-94483384 Neighboring gene Sharpr-MPRA regulatory region 4126 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94518750-94519679 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:94526511-94527710 Neighboring gene interferon alpha inducible protein 27 like 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:94576419-94577618 Neighboring gene interferon alpha inducible protein 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 (DDX24), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    rev Decreased viral RNA packaging as a result of DDX24-knockdown is observed only in the context of Rev/RRE-dependent but not CTE (constitutive transport element)-mediated nuclear export of viral RNA PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables RNA helicase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX24
    Names
    DEAD (Asp-Glu-Ala-Asp) box helicase 24
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
    DEAD box protein 24
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24
    S. cerevisiae CHL1-like helicase
    NP_065147.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020414.4NP_065147.1  ATP-dependent RNA helicase DDX24

      See identical proteins and their annotated locations for NP_065147.1

      Status: REVIEWED

      Source sequence(s)
      AL079302
      Consensus CDS
      CCDS9918.1
      UniProtKB/Swiss-Prot
      E7EMJ4, Q4V9L5, Q9GZR7
      UniProtKB/TrEMBL
      G3V529
      Related
      ENSP00000481495.1, ENST00000621632.5
      Conserved Domains (3) summary
      COG0513
      Location:191783
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:573681
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:194511
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      94048287..94081202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1162849..1195764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      88275602..88308519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)